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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2020-4-7-15</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1063</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Обновленные рекомендации EULAR/ERA–EDTA 2019 г. по терапии волчаночного нефрита. Комментарии экспертов. Часть I</article-title><trans-title-group xml:lang="en"><trans-title>The 2019 updated EULAR/ERA-EDTA guidelines for the management of lupus nephritis. Expert comments. Part I</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козловская</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlovskaya</surname><given-names>N. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117198, Москва, ул. Миклухо-Маклая, 6;Россия, 129327, Москва, ул. Ленская, 15</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyev</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><email xlink:type="simple">sksoloviev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асеева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aseeva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попкова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popkova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панафидина</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Panafidina</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра ревматологии Института профессионального образования</p><p>Россия, 115522, Москва, Каширское шоссе, 34А;Россия, 119991, Москва, ул. Трубецкая, 8, стр.2;</p></bio><bio xml:lang="en"><p>Department of Rheumatology, Institute of Professional Education</p><p>34A, Kashirskoe Shosse, Moscow 115522, Russia;8, Trubetskaya St., Build. 2, Moscow 119991, Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра ревматологии</p><p>Россия, 115522, Москва, Каширское шоссе, 34А;Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Department of Rheumatology</p><p>34A, Kashirskoe Shosse, Moscow 115522, Russia;1/2, Barrikadnaya St., Build. 1, Moscow 125993, Russia</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меснянкина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mesnyankina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никишина</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikishina</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А;</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»;&#13;
ГБУЗ г. Москвы «Городская клиническая больница им. А.К. Ерамишанцева Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia;&#13;
A.K. Eramishantsev City Clinical Hospital, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2020</year></pub-date><volume>14</volume><issue>4</issue><fpage>7</fpage><lpage>15</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козловская Н.Л., Соловьев С.К., Асеева Е.А., Попкова Т.В., Панафидина Т.А., Насонов Е.Л., Лила А.М., Меснянкина А.А., Никишина Н.Ю., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Козловская Н.Л., Соловьев С.К., Асеева Е.А., Попкова Т.В., Панафидина Т.А., Насонов Е.Л., Лила А.М., Меснянкина А.А., Никишина Н.Ю.</copyright-holder><copyright-holder xml:lang="en">Kozlovskaya N.L., Solovyev S.K., Aseeva E.A., Popkova T.V., Panafidina T.A., Nasonov E.L., Lila A.M., Mesnyankina A.A., Nikishina N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1063">https://mrj.ima-press.net/mrj/article/view/1063</self-uri><abstract><p>Представлены основные положения обновленных рекомендаций EULAR/ ERA–EDTA 2019 г. по терапии волчаночного нефрита. Обсуждается технология подготовки рекомендаций международной группой ревматологов, нефрологов, морфологов и педиатров. В основной части содержатся рекомендации по применению индукционной и поддерживающей терапии с использованием иммуносупрессоров, глюкокортикоидов и генно-инженерных биологических препаратов. Рассмотрены вопросы ведения пациенток с беременностью и терминальной почечной недостаточностью.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents the main provisions of the 2019 updated European League Against Rheumatism (EULAR)/European Renal Association (ERA) – European Dialysis and Transplant Association (EDTA) guidelines for the management of lupus nephritis. It discusses the technology of preparing recommendations by an international group of rheumatologists, nephrologists, morphologists, and pediatricians. The main part contains recommendations on the use of induction and maintenance therapy with immunosuppressants, glucocorticoids, and biological agents. The issues relating to the management of pregnant patients with end-stage renal failure are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>системная красная волчанка</kwd><kwd>волчаночный нефрит</kwd><kwd>клинические рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>systemic lupus erythematosus</kwd><kwd>lupus nephritis</kwd><kwd>clinical guidelines</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена в рамках научной темы № 0514-2019-0013 «Мультимодальные подходы выбора инновационной терапии системных заболеваний соединительной ткани» (АААА-А19-119021190145-2).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus. Arthritis Rheum. 2006 Aug;54(8):2550-7. doi: 10.1002/art.21955.</mixed-citation><mixed-citation xml:lang="en">Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus. Arthritis Rheum. 2006 Aug;54(8):2550-7. doi: 10.1002/art.21955.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003 Sep;82(5):299-308. doi: 10.1097/01.md.0000091181.93122.55.</mixed-citation><mixed-citation xml:lang="en">Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003 Sep;82(5):299-308. doi: 10.1097/01.md.0000091181.93122.55.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Seligman VA, Lum RF, Olson JL, et al. Demographic differences in the development of lupus nephritis: a retrospective analysis. Am J Med. 2002 Jun 15;112(9):726-9. doi: 10.1016/s0002-9343(02)01118-x.</mixed-citation><mixed-citation xml:lang="en">Seligman VA, Lum RF, Olson JL, et al. Demographic differences in the development of lupus nephritis: a retrospective analysis. Am J Med. 2002 Jun 15;112(9):726-9. doi: 10.1016/s0002-9343(02)01118-x.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wilhelmus S, Bajema IM, Bertsias GK, et al. Lupus nephritis management guidelines compared. Nephrol Dial Transplant. 2016 Jun; 31(6):904-13. doi: 10.1093/ndt/gfv102. Epub 2015 Apr 28.</mixed-citation><mixed-citation xml:lang="en">Wilhelmus S, Bajema IM, Bertsias GK, et al. Lupus nephritis management guidelines compared. Nephrol Dial Transplant. 2016 Jun; 31(6):904-13. doi: 10.1093/ndt/gfv102. Epub 2015 Apr 28.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ, редактор. Российские клинические рекомендации. Ревматология. Москва: ГЭОТАР-Медиа; 2017. 464 с.</mixed-citation><mixed-citation xml:lang="en">Nasonov EL, editor. Rossiiskie klinicheskie rekomendatsii. Revmatologiya [Russian clinical guidelines. Rheumatology]. Moscow: GEOTAR-Media; 2017. 464 p.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. Clin J Am Soc Nephrol. 2017 May 8;12(5):825-835. doi: 10.2215/CJN.05780616. Epub 2016 Nov 7.</mixed-citation><mixed-citation xml:lang="en">Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. Clin J Am Soc Nephrol. 2017 May 8;12(5):825-835. doi: 10.2215/CJN.05780616. Epub 2016 Nov 7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Parikh SV, Rovin BH. Current and Emerging Therapies for Lupus Nephritis. J Am Soc Nephrol. 2016 Oct;27(10):2929-39. doi: 10.1681/ASN.2016040415. Epub 2016 Jun 9.</mixed-citation><mixed-citation xml:lang="en">Parikh SV, Rovin BH. Current and Emerging Therapies for Lupus Nephritis. J Am Soc Nephrol. 2016 Oct;27(10):2929-39. doi: 10.1681/ASN.2016040415. Epub 2016 Jun 9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tunnicliffe DJ, Palmer SC, Henderson L, et al. Immunosuppressive Treatment for Proliferative Lupus Nephritis. Cochrane Database Syst Rev. 2018 Jun 29;6(6): CD002922. doi: 10.1002/14651858.CD002922.pub4.</mixed-citation><mixed-citation xml:lang="en">Tunnicliffe DJ, Palmer SC, Henderson L, et al. Immunosuppressive Treatment for Proliferative Lupus Nephritis. Cochrane Database Syst Rev. 2018 Jun 29;6(6): CD002922. doi: 10.1002/14651858.CD002922.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zickert A, Sundelin B, Svenungsson E, Gunnarsson I. Role of early repeated renal biopsies in lupus nephritis. Lupus Sci Med. 2014 Aug 6;1(1):e000018. doi: 10.1136/lupus2014-000018. eCollection 2014.</mixed-citation><mixed-citation xml:lang="en">Zickert A, Sundelin B, Svenungsson E, Gunnarsson I. Role of early repeated renal biopsies in lupus nephritis. Lupus Sci Med. 2014 Aug 6;1(1):e000018. doi: 10.1136/lupus2014-000018. eCollection 2014.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bertsias GK, Tektonidou M, Amoura Z, et al. Joint European League against rheumatism and European renal AssociationEuropean dialysis and transplant association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012 Nov;71(11): 1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31.</mixed-citation><mixed-citation xml:lang="en">Bertsias GK, Tektonidou M, Amoura Z, et al. Joint European League against rheumatism and European renal AssociationEuropean dialysis and transplant association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012 Nov;71(11): 1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fanouriakis A, Kostopoulou M, Cheema K, et al. 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERAEDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis. 2020 Jun;79(6):713-23. doi: 10.1136/annrheumdis2020-216924. Epub 2020 Mar 27.</mixed-citation><mixed-citation xml:lang="en">Fanouriakis A, Kostopoulou M, Cheema K, et al. 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERAEDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis. 2020 Jun;79(6):713-23. doi: 10.1136/annrheumdis2020-216924. Epub 2020 Mar 27.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D, Aletaha D, Carmona L, et al. 2014 update of the EULAR standardised operating procedures for EULAR-endorsed recommendations. Ann Rheum Dis. 2015 Jan; 74(1):8-13. doi: 10.1136/annrheumdis-2014-206350. Epub 2014 Sep 26.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D, Aletaha D, Carmona L, et al. 2014 update of the EULAR standardised operating procedures for EULAR-endorsed recommendations. Ann Rheum Dis. 2015 Jan; 74(1):8-13. doi: 10.1136/annrheumdis-2014-206350. Epub 2014 Sep 26.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Brouwers MC, Kho ME, Browman GP, et al. AGREE II: advancing Guideline development, reporting and evaluation in health care. CMAJ. 2010 Dec 14;182(18):E839-42. doi: 10.1503/cmaj.090449. Epub 2010 Jul 5.</mixed-citation><mixed-citation xml:lang="en">Brouwers MC, Kho ME, Browman GP, et al. AGREE II: advancing Guideline development, reporting and evaluation in health care. CMAJ. 2010 Dec 14;182(18):E839-42. doi: 10.1503/cmaj.090449. Epub 2010 Jul 5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int. 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x.</mixed-citation><mixed-citation xml:lang="en">Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int. 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Erre GL, Bosincu L, Faedda R, et al. Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study. Rheumatol Int. 2014 Apr;34(4):535-41. doi: 10.1007/s00296-013-2900-3.</mixed-citation><mixed-citation xml:lang="en">Erre GL, Bosincu L, Faedda R, et al. Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study. Rheumatol Int. 2014 Apr;34(4):535-41. doi: 10.1007/s00296-013-2900-3.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rijnink EC, Teng YKO, Wilhelmus S, et al. Clinical and histopathologic characteristics associated with renal outcomes in lupus nephritis. Clin J Am Soc Nephrol. 2017 May 8; 12(5):734-43. doi: 10.2215/CJN.10601016. Epub 2017 May 4.</mixed-citation><mixed-citation xml:lang="en">Rijnink EC, Teng YKO, Wilhelmus S, et al. Clinical and histopathologic characteristics associated with renal outcomes in lupus nephritis. Clin J Am Soc Nephrol. 2017 May 8; 12(5):734-43. doi: 10.2215/CJN.10601016. Epub 2017 May 4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dall'Era M, Cisternas MG, Smilek DE, et al. Predictors of long-term renal outcome in lupus nephritis trials: lessons learned from the Euro-Lupus nephritis cohort. Arthritis Rheumatol. 2015 May;67(5):1305-13. doi: 10.1002/art.39026.</mixed-citation><mixed-citation xml:lang="en">Dall'Era M, Cisternas MG, Smilek DE, et al. Predictors of long-term renal outcome in lupus nephritis trials: lessons learned from the Euro-Lupus nephritis cohort. Arthritis Rheumatol. 2015 May;67(5):1305-13. doi: 10.1002/art.39026.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tamirou F, D'Cruz D, Sangle S, et al. Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis. Ann Rheum Dis. 2016 Mar; 75(3):526-31. doi: 10.1136/annrheumdis2014-206897. Epub 2015 Mar 10.</mixed-citation><mixed-citation xml:lang="en">Tamirou F, D'Cruz D, Sangle S, et al. Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis. Ann Rheum Dis. 2016 Mar; 75(3):526-31. doi: 10.1136/annrheumdis2014-206897. Epub 2015 Mar 10.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tamirou F, Lauwerys BR, Dall'Era M, et al. A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the maintain nephritis trial. Lupus Sci Med. 2015 Nov 12;2(1):e000123. doi: 10.1136/lupus-2015-000123. eCollection 2015.</mixed-citation><mixed-citation xml:lang="en">Tamirou F, Lauwerys BR, Dall'Era M, et al. A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the maintain nephritis trial. Lupus Sci Med. 2015 Nov 12;2(1):e000123. doi: 10.1136/lupus-2015-000123. eCollection 2015.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mackay M, Dall'Era M, Fishbein J, et al. Establishing surrogate kidney end points for lupus nephritis clinical trials: development and validation of a novel approach to predict future kidney outcomes. Arthritis Rheumatol. 2019 Mar;71(3):411-19. doi: 10.1002/art.40724. Epub 2019 Feb 1.</mixed-citation><mixed-citation xml:lang="en">Mackay M, Dall'Era M, Fishbein J, et al. Establishing surrogate kidney end points for lupus nephritis clinical trials: development and validation of a novel approach to predict future kidney outcomes. Arthritis Rheumatol. 2019 Mar;71(3):411-19. doi: 10.1002/art.40724. Epub 2019 Feb 1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ugolini-Lopes MR, Seguro LPC, Castro MXF, et al. Early proteinuria response: a valid real-life situation predictor of long-term lupus renal outcome in an ethnically diverse group with severe biopsyproven nephritis? Lupus Sci Med. 2017 Jun 12;4(1):e000213. doi: 10.1136/lupus-2017-000213. eCollection 2017.</mixed-citation><mixed-citation xml:lang="en">Ugolini-Lopes MR, Seguro LPC, Castro MXF, et al. Early proteinuria response: a valid real-life situation predictor of long-term lupus renal outcome in an ethnically diverse group with severe biopsyproven nephritis? Lupus Sci Med. 2017 Jun 12;4(1):e000213. doi: 10.1136/lupus-2017-000213. eCollection 2017.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Illei GG, Austin HA, Crane M, et al. Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Ann Intern Med. 2001 Aug 21;135(4):248-57. doi: 10.7326/0003-4819-135-4-200108210-00009.</mixed-citation><mixed-citation xml:lang="en">Illei GG, Austin HA, Crane M, et al. Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Ann Intern Med. 2001 Aug 21;135(4):248-57. doi: 10.7326/0003-4819-135-4-200108210-00009.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Dall'Era M, Stone D, Levesque V, et al. Identification of biomarkers that predict response to treatment of lupus nephritis with mycophenolate mofetil or pulse cyclophosphamide. Arthritis Care Res (Hoboken). 2011; 63:351-7. 2011 Mar;63(3). doi: 10.1002/acr.20397. Epub 2010 Nov 15.7.</mixed-citation><mixed-citation xml:lang="en">Dall'Era M, Stone D, Levesque V, et al. Identification of biomarkers that predict response to treatment of lupus nephritis with mycophenolate mofetil or pulse cyclophosphamide. Arthritis Care Res (Hoboken). 2011; 63:351-7. 2011 Mar;63(3). doi: 10.1002/acr.20397. Epub 2010 Nov 15.7.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dall'Era M, Levesque V, Solomons N, et al. Identification of clinical and serological factors during induction treatment of lupus nephritis that are associated with renal outcome. Lupus Sci Med. 2015 May 20;2(1): e000089. doi: 10.1136/lupus-2015-000089. eCollection 2015.</mixed-citation><mixed-citation xml:lang="en">Dall'Era M, Levesque V, Solomons N, et al. Identification of clinical and serological factors during induction treatment of lupus nephritis that are associated with renal outcome. Lupus Sci Med. 2015 May 20;2(1): e000089. doi: 10.1136/lupus-2015-000089. eCollection 2015.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Touma Z, Urowitz MB, IbaЦez D, et al. Time to recovery from proteinuria in patients with lupus nephritis receiving standard treatment. J Rheumatol. 2014 Apr;41(4):688-97. doi: 10.3899/jrheum.130005. Epub 2014 Jan 15.</mixed-citation><mixed-citation xml:lang="en">Touma Z, Urowitz MB, IbaЦez D, et al. Time to recovery from proteinuria in patients with lupus nephritis receiving standard treatment. J Rheumatol. 2014 Apr;41(4):688-97. doi: 10.3899/jrheum.130005. Epub 2014 Jan 15.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tunnicliffe DJ, Palmer SC, Henderson L, et al. Immunosuppressive treatment for proliferative lupus nephritis. Cochrane Database Syst Rev. 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4.</mixed-citation><mixed-citation xml:lang="en">Tunnicliffe DJ, Palmer SC, Henderson L, et al. Immunosuppressive treatment for proliferative lupus nephritis. Cochrane Database Syst Rev. 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">ACCESS Trial Group. Treatment of lupus nephritis with abatacept: the abatacept and cyclophosphamide combination efficacy and safety study. Arthritis Rheumatol. 2014 Nov; 66(11):3096-104. doi: 10.1002/art.38790.</mixed-citation><mixed-citation xml:lang="en">ACCESS Trial Group. Treatment of lupus nephritis with abatacept: the abatacept and cyclophosphamide combination efficacy and safety study. Arthritis Rheumatol. 2014 Nov; 66(11):3096-104. doi: 10.1002/art.38790.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Mehra S, Usdadiya JB, Jain VK, et al. Comparing the efficacy of low-dose vs highdose cyclophosphamide regimen as induction therapy in the treatment of proliferative lupus nephritis: a single center study. Rheumatol Int. 2018 Apr;38(4):557-68. doi: 10.1007/s00296-018-3995-3. Epub 2018 Feb 15.</mixed-citation><mixed-citation xml:lang="en">Mehra S, Usdadiya JB, Jain VK, et al. Comparing the efficacy of low-dose vs highdose cyclophosphamide regimen as induction therapy in the treatment of proliferative lupus nephritis: a single center study. Rheumatol Int. 2018 Apr;38(4):557-68. doi: 10.1007/s00296-018-3995-3. Epub 2018 Feb 15.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Boumpas DT, Austin HA, Vaughn EM, et al. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet. 1992 Sep 26;340(8822):741-5. doi: 10.1016/0140-6736(92)92292-n.</mixed-citation><mixed-citation xml:lang="en">Boumpas DT, Austin HA, Vaughn EM, et al. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet. 1992 Sep 26;340(8822):741-5. doi: 10.1016/0140-6736(92)92292-n.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rovin BH, Solomons N, Pendergraft WF, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019 Jan;95(1): 219-31. doi: 10.1016/j.kint.2018.08.025. Epub 2018 Nov 9.</mixed-citation><mixed-citation xml:lang="en">Rovin BH, Solomons N, Pendergraft WF, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019 Jan;95(1): 219-31. doi: 10.1016/j.kint.2018.08.025. Epub 2018 Nov 9.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S, Li X, Qu L, et al. Tacrolimus versus cyclophosphamide as treatment for diffuse proliferative or membranous lupus nephritis: a non-randomized prospective cohort study. Lupus. 2012 Aug;21(9):1025-35. doi: 10.1177/0961203312448105. Epub 2012 May 8.</mixed-citation><mixed-citation xml:lang="en">Wang S, Li X, Qu L, et al. Tacrolimus versus cyclophosphamide as treatment for diffuse proliferative or membranous lupus nephritis: a non-randomized prospective cohort study. Lupus. 2012 Aug;21(9):1025-35. doi: 10.1177/0961203312448105. Epub 2012 May 8.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Chen W, Tang X, Liu Q, et al. Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: a multicenter randomized clinical trial. Am J Kidney Dis. 2018 Jul; 72(1):157. doi: 10.1053/j.ajkd.2018.05.001. Epub 2018 May 16.</mixed-citation><mixed-citation xml:lang="en">Chen W, Tang X, Liu Q, et al. Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: a multicenter randomized clinical trial. Am J Kidney Dis. 2018 Jul; 72(1):157. doi: 10.1053/j.ajkd.2018.05.001. Epub 2018 May 16.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Choi CB, Won S, Bae SC. Outcomes of multitarget therapy using mycophenolate mofetil and tacrolimus for refractory or relapsing lupus nephritis. Lupus. 2018 May; 27(6):1007-11. doi: 10.1177/0961203318758505. Epub 2018 Feb 15.</mixed-citation><mixed-citation xml:lang="en">Choi CB, Won S, Bae SC. Outcomes of multitarget therapy using mycophenolate mofetil and tacrolimus for refractory or relapsing lupus nephritis. Lupus. 2018 May; 27(6):1007-11. doi: 10.1177/0961203318758505. Epub 2018 Feb 15.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hannah J, Casian A, D'Cruz D. Tacrolimus use in lupus nephritis: a systematic review and meta-analysis. Autoimmun Rev. 2016 Jan;15(1):93-101. doi: 10.1016/j.autrev.2015.09.006. Epub 2015 Sep 30.</mixed-citation><mixed-citation xml:lang="en">Hannah J, Casian A, D'Cruz D. Tacrolimus use in lupus nephritis: a systematic review and meta-analysis. Autoimmun Rev. 2016 Jan;15(1):93-101. doi: 10.1016/j.autrev.2015.09.006. Epub 2015 Sep 30.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Z, Zhang H, Liu Z, et al. Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med. 2015 Jan 6;162(1):18-26. doi: 10.7326/M14-1030.</mixed-citation><mixed-citation xml:lang="en">Liu Z, Zhang H, Liu Z, et al. Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med. 2015 Jan 6;162(1):18-26. doi: 10.7326/M14-1030.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer SC, Tunnicliffe DJ, Singh-Grewal D, et al. Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials. Am J Kidney Dis. 2017 Sep;70(3):324-36. doi: 10.1053/j.ajkd.2016.12.008. Epub 2017 Feb 21.</mixed-citation><mixed-citation xml:lang="en">Palmer SC, Tunnicliffe DJ, Singh-Grewal D, et al. Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials. Am J Kidney Dis. 2017 Sep;70(3):324-36. doi: 10.1053/j.ajkd.2016.12.008. Epub 2017 Feb 21.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Yap DYH, Yu X, Chen XM, et al. Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome. Nephrology (Carlton). 2012 May; 17(4):352-7. doi: 10.1111/j.1440-1797.2012.01574.x.</mixed-citation><mixed-citation xml:lang="en">Yap DYH, Yu X, Chen XM, et al. Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome. Nephrology (Carlton). 2012 May; 17(4):352-7. doi: 10.1111/j.1440-1797.2012.01574.x.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Pokroy-Shapira E, Gelernter I, Molad Y. Evolution of chronic kidney disease in patients with systemic lupus erythematosus over a long-period follow-up: a single-center inception cohort study. Clin Rheumatol. 2014 May;33(5):649-57. doi: 10.1007/s10067-014-2527-0. Epub 2014 Feb 19.</mixed-citation><mixed-citation xml:lang="en">Pokroy-Shapira E, Gelernter I, Molad Y. Evolution of chronic kidney disease in patients with systemic lupus erythematosus over a long-period follow-up: a single-center inception cohort study. Clin Rheumatol. 2014 May;33(5):649-57. doi: 10.1007/s10067-014-2527-0. Epub 2014 Feb 19.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Cunha C, Alexander S, Ashby D, et al. Hydroxycloroquine blood concentration in lupus nephritis: a determinant of disease outcome? Nephrol Dial Transplant. 2018 Sep 1; 33(9):1604-10. doi: 10.1093/ndt/gfx318.</mixed-citation><mixed-citation xml:lang="en">Cunha C, Alexander S, Ashby D, et al. Hydroxycloroquine blood concentration in lupus nephritis: a determinant of disease outcome? Nephrol Dial Transplant. 2018 Sep 1; 33(9):1604-10. doi: 10.1093/ndt/gfx318.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Moroni G, Gallelli B, Quaglini S, et al. Withdrawal of therapy in patients with proliferative lupus nephritis: long-term follow-up. Nephrol Dial Transplant. 2006 Jun;21(6): 1541-8. doi: 10.1093/ndt/gfk073. Epub 2006 Feb 2.</mixed-citation><mixed-citation xml:lang="en">Moroni G, Gallelli B, Quaglini S, et al. Withdrawal of therapy in patients with proliferative lupus nephritis: long-term follow-up. Nephrol Dial Transplant. 2006 Jun;21(6): 1541-8. doi: 10.1093/ndt/gfk073. Epub 2006 Feb 2.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Mok CC, Tse SM, Chan KL, et al. Effect of immunosuppressive therapies on survival of systemic lupus erythematosus: a propensity score analysis of a longitudinal cohort. Lupus. 2018 Apr;27(5):722-7. doi: 10.1177/0961203317739129. Epub 2017 Oct 31.</mixed-citation><mixed-citation xml:lang="en">Mok CC, Tse SM, Chan KL, et al. Effect of immunosuppressive therapies on survival of systemic lupus erythematosus: a propensity score analysis of a longitudinal cohort. Lupus. 2018 Apr;27(5):722-7. doi: 10.1177/0961203317739129. Epub 2017 Oct 31.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Pakchotanon R, Gladman DD, Su J, et al. Sustained complete renal remission is a predictor of reduced mortality, chronic kidney disease and end-stage renal disease in lupus nephritis. Lupus. 2018 Mar;27(3): 468-74. doi: 10.1177/0961203317726376. Epub 2017 Aug 31.</mixed-citation><mixed-citation xml:lang="en">Pakchotanon R, Gladman DD, Su J, et al. Sustained complete renal remission is a predictor of reduced mortality, chronic kidney disease and end-stage renal disease in lupus nephritis. Lupus. 2018 Mar;27(3): 468-74. doi: 10.1177/0961203317726376. Epub 2017 Aug 31.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Marmor MF, Kellner U, Lai TYY, et al. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 revision). Ophthalmology. 2016 Jun; 123(6):1386-94. doi: 10.1016/j.ophtha.2016.01.058. Epub 2016 Mar 16.</mixed-citation><mixed-citation xml:lang="en">Marmor MF, Kellner U, Lai TYY, et al. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 revision). Ophthalmology. 2016 Jun; 123(6):1386-94. doi: 10.1016/j.ophtha.2016.01.058. Epub 2016 Mar 16.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Arends S, Grootscholten C, Derksen RH, et al. Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. Ann Rheum Dis. 2012 Jun;71(6):966-73. doi: 10.1136/annrheumdis-2011-200384. Epub 2011 Nov 29.</mixed-citation><mixed-citation xml:lang="en">Arends S, Grootscholten C, Derksen RH, et al. Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. Ann Rheum Dis. 2012 Jun;71(6):966-73. doi: 10.1136/annrheumdis-2011-200384. Epub 2011 Nov 29.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Yap DYH, Tang C, Ma MKM, et al. Longterm data on disease flares in patients with proliferative lupus nephritis in recent years. J Rheumatol. 2017 Sep;44(9):1375-83. doi: 10.3899/jrheum.170226. Epub 2017 Jul 1.</mixed-citation><mixed-citation xml:lang="en">Yap DYH, Tang C, Ma MKM, et al. Longterm data on disease flares in patients with proliferative lupus nephritis in recent years. J Rheumatol. 2017 Sep;44(9):1375-83. doi: 10.3899/jrheum.170226. Epub 2017 Jul 1.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Moroni G, Quaglini S, Gravellone L, et al. Membranous nephropathy in systemic lupus erythematosus: long-term outcome and prognostic factors of 103 patients. Semin Arthritis Rheum. 2012 Apr;41(5):642-51. doi: 10.1016/j.semarthrit.2011.08.002. Epub 2012 Jan 28.</mixed-citation><mixed-citation xml:lang="en">Moroni G, Quaglini S, Gravellone L, et al. Membranous nephropathy in systemic lupus erythematosus: long-term outcome and prognostic factors of 103 patients. Semin Arthritis Rheum. 2012 Apr;41(5):642-51. doi: 10.1016/j.semarthrit.2011.08.002. Epub 2012 Jan 28.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes das Neves M, Irlapati RVP, Isenberg D. Assessment of long-term remission in lupus nephritis patients: a retrospective analysis over 30 years. Rheumatology (Oxford). 2015 Aug;54(8):1403-7. doi: 10.1093/rheumatology/kev003. Epub 2015 Feb 27.</mixed-citation><mixed-citation xml:lang="en">Fernandes das Neves M, Irlapati RVP, Isenberg D. Assessment of long-term remission in lupus nephritis patients: a retrospective analysis over 30 years. Rheumatology (Oxford). 2015 Aug;54(8):1403-7. doi: 10.1093/rheumatology/kev003. Epub 2015 Feb 27.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Moroni G, Longhi S, Giglio E, et al. What happens after complete withdrawal of therapy in patients with lupus nephritis. Clin Exp Rheumatol. Jul-Aug 2013;31(4 Suppl 78): S75-81. Epub 2013 Oct 4.</mixed-citation><mixed-citation xml:lang="en">Moroni G, Longhi S, Giglio E, et al. What happens after complete withdrawal of therapy in patients with lupus nephritis. Clin Exp Rheumatol. Jul-Aug 2013;31(4 Suppl 78): S75-81. Epub 2013 Oct 4.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Moroni G, Gatto M, Raffiotta F, et al. Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate. Autoimmun Rev. 2018 Jan;17(1): 11-8. doi: 10.1016/j.autrev.2017.11.003. Epub 2017 Nov 3.</mixed-citation><mixed-citation xml:lang="en">Moroni G, Gatto M, Raffiotta F, et al. Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate. Autoimmun Rev. 2018 Jan;17(1): 11-8. doi: 10.1016/j.autrev.2017.11.003. Epub 2017 Nov 3.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera F, Mеrida E, Illescas ML, et al. Mycophenolate in refractory and relapsing lupus nephritis. Am J Nephrol. 2014;40(2): 105-12. doi: 10.1159/000365256. Epub 2014 Jul 30.</mixed-citation><mixed-citation xml:lang="en">Rivera F, Mеrida E, Illescas ML, et al. Mycophenolate in refractory and relapsing lupus nephritis. Am J Nephrol. 2014;40(2): 105-12. doi: 10.1159/000365256. Epub 2014 Jul 30.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Kasitanon N, Boripatkosol P, Louthrenoo W. Response to combination of mycophenolate mofetil, cyclosporin A and corticosteroid treatment in lupus nephritis patients with persistent proteinuria. Int J Rheum Dis. 2018 Jan; 21(1):200-7. doi: 10.1111/1756-185X.13152. Epub 2017 Sep 13.</mixed-citation><mixed-citation xml:lang="en">Kasitanon N, Boripatkosol P, Louthrenoo W. Response to combination of mycophenolate mofetil, cyclosporin A and corticosteroid treatment in lupus nephritis patients with persistent proteinuria. Int J Rheum Dis. 2018 Jan; 21(1):200-7. doi: 10.1111/1756-185X.13152. Epub 2017 Sep 13.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Mok CC, To CH, Yu KL, et al. Combined low-dose mycophenolate mofetil and tacrolimus for lupus nephritis with suboptimal response to standard therapy: a 12-month prospective study. Lupus. 2013 Oct;22(11):1135-41. doi: 10.1177/0961203313502864. Epub 2013 Aug 30.</mixed-citation><mixed-citation xml:lang="en">Mok CC, To CH, Yu KL, et al. Combined low-dose mycophenolate mofetil and tacrolimus for lupus nephritis with suboptimal response to standard therapy: a 12-month prospective study. Lupus. 2013 Oct;22(11):1135-41. doi: 10.1177/0961203313502864. Epub 2013 Aug 30.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Sheikholeslami M, Hajialilo M, Rasi Hashemi SS, et al. Low dose cyclosporine A in the treatment of resistant proliferative lupus nephritis. Mod Rheumatol. 2018 May;28(3):523-29. doi: 10.1080/14397595.2017.1352479. Epub 2017 Jul 28.</mixed-citation><mixed-citation xml:lang="en">Sheikholeslami M, Hajialilo M, Rasi Hashemi SS, et al. Low dose cyclosporine A in the treatment of resistant proliferative lupus nephritis. Mod Rheumatol. 2018 May;28(3):523-29. doi: 10.1080/14397595.2017.1352479. Epub 2017 Jul 28.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Fei Y, Wu Q, Zhang W, et al. Low-dose tacrolimus in treating lupus nephritis refractory to cyclophosphamide: a prospective cohort study. Clin Exp Rheumatol. Jan-Feb 2013;31(1):62-8. Epub 2012 Aug 30.</mixed-citation><mixed-citation xml:lang="en">Fei Y, Wu Q, Zhang W, et al. Low-dose tacrolimus in treating lupus nephritis refractory to cyclophosphamide: a prospective cohort study. Clin Exp Rheumatol. Jan-Feb 2013;31(1):62-8. Epub 2012 Aug 30.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Alshaiki F, Obaid E, Almuallim A, et al. Outcomes of rituximab therapy in refractory lupus: a meta-analysis. Eur J Rheumatol. 2018 Jul;5(2):118-26. doi: 10.5152/eurjrheum.2018.17096. Epub 2018 Feb 13.</mixed-citation><mixed-citation xml:lang="en">Alshaiki F, Obaid E, Almuallim A, et al. Outcomes of rituximab therapy in refractory lupus: a meta-analysis. Eur J Rheumatol. 2018 Jul;5(2):118-26. doi: 10.5152/eurjrheum.2018.17096. Epub 2018 Feb 13.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Weidenbusch M, Römmele C, Schröttle A, et al. Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis. Nephrol Dial Transplant. 2013 Jan;28(1):106-11. doi: 10.1093/ndt/gfs285. Epub 2012 Jul 3.</mixed-citation><mixed-citation xml:lang="en">Weidenbusch M, Römmele C, Schröttle A, et al. Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis. Nephrol Dial Transplant. 2013 Jan;28(1):106-11. doi: 10.1093/ndt/gfs285. Epub 2012 Jul 3.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Davies RJ, Sangle SR, Jordan NP, et al. Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis. Lupus. 2013 May; 22(6):574-82. doi: 10.1177/0961203313483376. Epub 2013 Apr 30.</mixed-citation><mixed-citation xml:lang="en">Davies RJ, Sangle SR, Jordan NP, et al. Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis. Lupus. 2013 May; 22(6):574-82. doi: 10.1177/0961203313483376. Epub 2013 Apr 30.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Jonsdottir T, Zickert A, Sundelin B, et al. Long-term follow-up in lupus nephritis patients treated with rituximab – clinical and histopathological response. Rheumatology (Oxford). 2013 May;52(5):847-55. doi: 10.1093/rheumatology/kes348. Epub 2013 Jan 3.</mixed-citation><mixed-citation xml:lang="en">Jonsdottir T, Zickert A, Sundelin B, et al. Long-term follow-up in lupus nephritis patients treated with rituximab – clinical and histopathological response. Rheumatology (Oxford). 2013 May;52(5):847-55. doi: 10.1093/rheumatology/kes348. Epub 2013 Jan 3.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J, Zhao Z, Hu X. Effect of rituximab on serum levels of anti-C1q and antineutrophil cytoplasmic autoantibodies in refractory severe lupus nephritis. Cell Biochem Biophys. 2015 May;72(1):197-201. doi: 10.1007/s12013-014-0437-z.</mixed-citation><mixed-citation xml:lang="en">Zhang J, Zhao Z, Hu X. Effect of rituximab on serum levels of anti-C1q and antineutrophil cytoplasmic autoantibodies in refractory severe lupus nephritis. Cell Biochem Biophys. 2015 May;72(1):197-201. doi: 10.1007/s12013-014-0437-z.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Gomez Mendez LM, Cascino MD, Garg J, et al. Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1502-9. doi: 10.2215/CJN.01070118. Epub 2018 Aug 8.</mixed-citation><mixed-citation xml:lang="en">Gomez Mendez LM, Cascino MD, Garg J, et al. Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1502-9. doi: 10.2215/CJN.01070118. Epub 2018 Aug 8.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">McCarthy EM, Sutton E, Nesbit S, et al. Short-term efficacy and safety of rituximab therapy in refractory systemic lupus erythematosus: results from the British Isles lupus assessment group biologics register. Rheumatology (Oxford). 2018 Mar 1;57(3): 470-79. doi: 10.1093/rheumatology/kex395.</mixed-citation><mixed-citation xml:lang="en">McCarthy EM, Sutton E, Nesbit S, et al. Short-term efficacy and safety of rituximab therapy in refractory systemic lupus erythematosus: results from the British Isles lupus assessment group biologics register. Rheumatology (Oxford). 2018 Mar 1;57(3): 470-79. doi: 10.1093/rheumatology/kex395.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandez-Nebro A, de la Fuente JLM, Carreno L, et al. Multicenter longitudinal study of B-lymphocyte depletion in refractory systemic lupus erythematosus: the LESIMAB study. Lupus. 2012 Sep;21(10):1063-76. doi: 10.1177/0961203312446627. Epub 2012 Jul 11.</mixed-citation><mixed-citation xml:lang="en">Fernandez-Nebro A, de la Fuente JLM, Carreno L, et al. Multicenter longitudinal study of B-lymphocyte depletion in refractory systemic lupus erythematosus: the LESIMAB study. Lupus. 2012 Sep;21(10):1063-76. doi: 10.1177/0961203312446627. Epub 2012 Jul 11.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Dooley MA, Houssiau F, Aranow C, et al. Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE. Lupus. 2013 Jan;22(1):63-72. doi: 10.1177/0961203312465781.</mixed-citation><mixed-citation xml:lang="en">Dooley MA, Houssiau F, Aranow C, et al. Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE. Lupus. 2013 Jan;22(1):63-72. doi: 10.1177/0961203312465781.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Stohl W, Schwarting A, Okada M, et al. Efficacy and safety of subcutaneous belimumab in systemic lupus erythematosus: a Fifty-Two-Week randomized, doubleblind, placebo-controlled study. Arthritis Rheumatol. 2017 May;69(5):1016-27. doi: 10.1002/art.40049. Epub 2017 Apr 7.</mixed-citation><mixed-citation xml:lang="en">Stohl W, Schwarting A, Okada M, et al. Efficacy and safety of subcutaneous belimumab in systemic lupus erythematosus: a Fifty-Two-Week randomized, doubleblind, placebo-controlled study. Arthritis Rheumatol. 2017 May;69(5):1016-27. doi: 10.1002/art.40049. Epub 2017 Apr 7.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Iaccarino L, Bettio S, Reggia R, et al. Effects of belimumab on flare rate and expected damage progression in patients with active systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2017 Jan;69(1):115-23. doi: 10.1002/acr.22971. Epub 2016 Nov 18.</mixed-citation><mixed-citation xml:lang="en">Iaccarino L, Bettio S, Reggia R, et al. Effects of belimumab on flare rate and expected damage progression in patients with active systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2017 Jan;69(1):115-23. doi: 10.1002/acr.22971. Epub 2016 Nov 18.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Sciascia S, Radin M, Yazdany J, et al. Efficacy of belimumab on renal outcomes in patients with systemic lupus erythematosus: a systematic review. Autoimmun Rev. 2017 Mar;16(3):287-293. doi: 10.1016/j.autrev.2017.01.010. Epub 2017 Jan 29.</mixed-citation><mixed-citation xml:lang="en">Sciascia S, Radin M, Yazdany J, et al. Efficacy of belimumab on renal outcomes in patients with systemic lupus erythematosus: a systematic review. Autoimmun Rev. 2017 Mar;16(3):287-293. doi: 10.1016/j.autrev.2017.01.010. Epub 2017 Jan 29.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Parodis I, Sjöwall C, Jönsen A, et al. Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus. Autoimmun Rev. 2017 Apr; 16(4):343-51. doi: 10.1016/j.autrev.2017.02.005. Epub 2017 Feb 13.</mixed-citation><mixed-citation xml:lang="en">Parodis I, Sjöwall C, Jönsen A, et al. Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus. Autoimmun Rev. 2017 Apr; 16(4):343-51. doi: 10.1016/j.autrev.2017.02.005. Epub 2017 Feb 13.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">GSK. https://www.gsk.com/en-gb/media/press-releasesgsk-announcespositive-headline-results-in-phase-3-studyof-benlysta-in-patients-with-lupus- nephritis/</mixed-citation><mixed-citation xml:lang="en">GSK. https://www.gsk.com/en-gb/media/press-releasesgsk-announcespositive-headline-results-in-phase-3-studyof-benlysta-in-patients-with-lupus- nephritis/</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Kraaij T, Kamerling SWA, de Rooij ENM, et al. The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus. J Autoimmun. 2018 Jul; 91:45-54. doi: 10.1016/j.jaut.2018.03.003. Epub 2018 Apr 7.</mixed-citation><mixed-citation xml:lang="en">Kraaij T, Kamerling SWA, de Rooij ENM, et al. The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus. J Autoimmun. 2018 Jul; 91:45-54. doi: 10.1016/j.jaut.2018.03.003. Epub 2018 Apr 7.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Sakthiswary R, D’Cruz D. Intravenous immunoglobulin in the therapeutic armamentarium of systemic lupus erythematosus: a systematic review and meta-analysis. Medicine (Baltimore). 2014 Oct;93(16):e86. doi: 10.1097/MD.0000000000000086.</mixed-citation><mixed-citation xml:lang="en">Sakthiswary R, D’Cruz D. Intravenous immunoglobulin in the therapeutic armamentarium of systemic lupus erythematosus: a systematic review and meta-analysis. Medicine (Baltimore). 2014 Oct;93(16):e86. doi: 10.1097/MD.0000000000000086.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
