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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2021-1-9-14</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1093</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Обновленные рекомендации EULAR/ERA–EDTA 2019 г. по терапии волчаночного нефрита. Комментарии экспертов. Часть II</article-title><trans-title-group xml:lang="en"><trans-title>The 2019 updated EULAR/ERA-EDTA guidelines for the management of lupus nephritis. Expert comments. Part II</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4275-0315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козловская</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlovskaya</surname><given-names>N. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117198, Москва, ул. Миклухо-Маклая, 6,</p><p>129327, Москва, ул. Ленская, 15</p></bio><bio xml:lang="en"><p>6, Miklukho-Maklai St., Moscow 117198,</p><p>15, Lenskaya St., Moscow 129327</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5206-1732</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyev</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Константинович Соловьев</p><p>115522, Москва, Каширское шоссе, 34А</p><p> </p></bio><bio xml:lang="en"><p>Sergei Konstantovich Solovyev</p><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">sksoloviev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1663-7810</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асеева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aseeva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5793-4689</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попкова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popkova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1053-6952</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панафидина</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Panafidina</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1598-8360</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра ревматологии Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</p><p>115522, Москва, Каширское шоссе, 34А, </p><p>119991, Москва, ул. Трубецкая, 8, стр. 2</p></bio><bio xml:lang="en"><p>Department of Rheumatology Institute of Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</p><p>34A, Kashirskoe Shosse, Moscow 115522, </p><p>8, Trubetskaya St., Build. 2, Moscow 119991</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</p><p>115522, Москва, Каширское шоссе, 34А, </p><p>125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</p><p>34A, Kashirskoe Shosse, Moscow 115522, </p><p>1/2, Barrikadnaya St., Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5411-7317</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меснянкина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mesnyankina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4160-7218</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никишина</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikishina</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»;&#13;
ГБУЗ г. Москвы «Городская клиническая больница им. А.К. Ерамишанцева Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia; &#13;
A.K. Eramishantsev City Clinical Hospital, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Institute of Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>02</month><year>2021</year></pub-date><volume>15</volume><issue>1</issue><fpage>9</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козловская Н.Л., Соловьев С.К., Асеева Е.А., Попкова Т.В., Панафидина Т.А., Насонов Е.Л., Лила А.М., Меснянкина А.А., Никишина Н.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Козловская Н.Л., Соловьев С.К., Асеева Е.А., Попкова Т.В., Панафидина Т.А., Насонов Е.Л., Лила А.М., Меснянкина А.А., Никишина Н.Ю.</copyright-holder><copyright-holder xml:lang="en">Kozlovskaya N.L., Solovyev S.K., Aseeva E.A., Popkova T.V., Panafidina T.A., Nasonov E.L., Lila A.M., Mesnyankina A.A., Nikishina N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1093">https://mrj.ima-press.net/mrj/article/view/1093</self-uri><abstract><p>Представлены основные положения обновленных рекомендаций EULAR/ERA–EDTA 2019 г. по терапии волчаночного нефрита (ВН), подготовленных международной группой ревматологов, нефрологов, морфологов и педиатров. Во второй части статьи обсуждаются дополнительная терапия, мониторинг и прогноз при ВН, вопросы ведения пациентов с терминальной почечной недостаточностью, антифосфолипидным синдромом. Уделено внимание проблеме ВН и беременности, а также тактике ведения пациентов детского возраста с поражением почек.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents the main provisions of the updated 2019 EULAR/ERA-EDTA guidelines for the lupus nephritis (LN) therapy, which have been prepared by an international group of rheumatologists, nephrologists, morphologists, and pediatricians. Part 2 of the article discusses additional therapy, monitoring, and prognosis for LN, and the management of patients with end-stage renal failure and antiphospholipid syndrome. Attention is paid to the problem of LN and pregnancy, as well as to the management of pediatric patients with kidney damage.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>волчаночный нефрит</kwd><kwd>клинические рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lupus nephritis</kwd><kwd>clinical practice guidelines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tselios K, Koumaras C, Urowitz MB, et al. Do current arterial hypertension treatment guidelines apply to systemic lupus erythematosus patients? A critical appraisal. Semin Arthritis Rheum. 2014 Feb;43(4):521-5. doi: 10.1016/j.semarthrit.2013.07.007. Epub 2013 Aug 15.</mixed-citation><mixed-citation xml:lang="en">Tselios K, Koumaras C, Urowitz MB, et al. Do current arterial hypertension treatment guidelines apply to systemic lupus erythematosus patients? A critical appraisal. Semin Arthritis Rheum. 2014 Feb;43(4):521-5. doi: 10.1016/j.semarthrit.2013.07.007. Epub 2013 Aug 15.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Van Assen S, Agmon-Levin N, Elkayam O, et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011 Mar;70(3):414-22. doi: 10.1136/ard.2010.137216. Epub 2010 Dec 3.</mixed-citation><mixed-citation xml:lang="en">Van Assen S, Agmon-Levin N, Elkayam O, et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011 Mar;70(3):414-22. doi: 10.1136/ard.2010.137216. Epub 2010 Dec 3.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Белов БС, Соловьев СК, Тарасова ГМ, Асеева ЕА. Вакцинация у больных системной красной волчанкой: результаты и перспективы. Научно-практическая ревматология. 2018;56(3):373-9.</mixed-citation><mixed-citation xml:lang="en">Belov BS, Solov'ev SK, Tarasova GM, Aseeva EA. Vaccination in patients with systemic lupus erythematosus: results and prospects. Nauchno-prakticheskaya revmatologiya. 2018;56(3):373-9. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова ГМ, Белов БС, Буханова ДВ и др. Изучение иммуногенности и безопасности 23-валентной полисахаридной пневмококковой вакцины у больных системной красной волчанкой. Научно-практическая ревматология. 2018;56(4):433-8.</mixed-citation><mixed-citation xml:lang="en">Tarasova GM, Belov BS, Bukhanova DV, et al. Study of the immunogenicity and safety of 23-valent polysaccharide pneumococcal vaccine in patients with systemic lupus erythematosus. Nauchno-prakticheskaya revmatologiya. 2018;56(4):433-8. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J. 2016 Aug 1;37(29):2315-81. doi: 10.1093/eurheartj/ehw106. Epub 2016 May 23.</mixed-citation><mixed-citation xml:lang="en">Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J. 2016 Aug 1;37(29):2315-81. doi: 10.1093/eurheartj/ehw106. Epub 2016 May 23.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Попкова ТВ, Алекберова ЗС, Александрова ЕН и др. Факторы риска кардиоваскулярных нарушений и атеросклероза при системной красной волчанке. Научно-практическая ревматология. 2004; 42(4):10-4.</mixed-citation><mixed-citation xml:lang="en">Popkova TV, Alekberova ZS, Aleksandrova EN, et al. Risk factors for cardiovascular disorders and atherosclerosis in systemic lupus erythematosus. Nauchno-prakticheskaya revmatologiya. 2004;42(4):10-4. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Попкова ТВ, Панафиндина ТА, Новикова ДС и др. Значение маркеров воспаления в развитии атеросклероза и его осложнений при системной красной волчанке. Научно-практическая ревматология. 2013;51(6):646-53.</mixed-citation><mixed-citation xml:lang="en">Popkova TV, Panafindina TA, Novikova DS, et al. The significance of inflammatory markers in the development of atherosclerosis and its complications in systemic lupus erythematosus. Nauchno-prakticheskaya revmatologiya. 2013;51(6):646-53. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tektonidou MG, Andreoli L, Limper M, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults. Ann Rheum Dis. 2019 Oct;78(10): 1296-304. doi: 10.1136/annrheumdis-2019-215213. Epub 2019 May 15.</mixed-citation><mixed-citation xml:lang="en">Tektonidou MG, Andreoli L, Limper M, et al. EULAR recommendations for the management of antiphospholipid syndrome in adults. Ann Rheum Dis. 2019 Oct;78(10): 1296-304. doi: 10.1136/annrheumdis-2019-215213. Epub 2019 May 15.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Arora S, Nika A, Trupin L, et al. Does systemic lupus erythematosus care provided in a lupus clinic result in higher quality of care than that provided in a general rheumatology clinic? Arthritis Care Res (Hoboken). 2018 Dec;70(12):1771-77. doi: 10.1002/acr.23569. Epub 2018 Nov 10.</mixed-citation><mixed-citation xml:lang="en">Arora S, Nika A, Trupin L, et al. Does systemic lupus erythematosus care provided in a lupus clinic result in higher quality of care than that provided in a general rheumatology clinic? Arthritis Care Res (Hoboken). 2018 Dec;70(12):1771-77. doi: 10.1002/acr.23569. Epub 2018 Nov 10.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Асеева ЕА, Соловьев СК, Попкова ТВ и др. Ведение пациентов с системной красной волчанкой в реальной клинической практике. Научно-практическая ревматология. 2019;57(2):191-6.</mixed-citation><mixed-citation xml:lang="en">Aseeva EA, Solov'ev SK, Popkova TV, et al. Management of patients with systemic lupus erythematosus in real clinical practice. Nauchno-prakticheskaya revmatologiya. 2019;57(2):191-6. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Medina-Rosas J, Yap KS, Anderson M, et al. Utility of urinary Protein-Creatinine ratio and protein content in a 24-hour urine collection in systemic lupus erythematosus: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2016 Sep;68(9): 1310-9. doi: 10.1002/acr.22828. Epub 2016 Jul 29.</mixed-citation><mixed-citation xml:lang="en">Medina-Rosas J, Yap KS, Anderson M, et al. Utility of urinary Protein-Creatinine ratio and protein content in a 24-hour urine collection in systemic lupus erythematosus: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2016 Sep;68(9): 1310-9. doi: 10.1002/acr.22828. Epub 2016 Jul 29.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Medina-Rosas J, Gladman DD, Su J, et al. Utility of untimed single urine protein/ creatinine ratio as a substitute for 24-h proteinuria for assessment of proteinuria in systemic lupus erythematosus. Arthritis Res Ther. 2015 Oct 24;17:296. doi: 10.1186/s13075-015-0808-x.</mixed-citation><mixed-citation xml:lang="en">Medina-Rosas J, Gladman DD, Su J, et al. Utility of untimed single urine protein/ creatinine ratio as a substitute for 24-h proteinuria for assessment of proteinuria in systemic lupus erythematosus. Arthritis Res Ther. 2015 Oct 24;17:296. doi: 10.1186/s13075-015-0808-x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Choi IA, Park JK, Lee EY, et al. Random spot urine protein to creatinine ratio is a reliable measure of proteinuria in lupus nephritis in Koreans. Clin Exp Rheumatol. Jul-Aug 2013; 31(4):584-8. Epub 2013 May 27.</mixed-citation><mixed-citation xml:lang="en">Choi IA, Park JK, Lee EY, et al. Random spot urine protein to creatinine ratio is a reliable measure of proteinuria in lupus nephritis in Koreans. Clin Exp Rheumatol. Jul-Aug 2013; 31(4):584-8. Epub 2013 May 27.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmoud GA, Zayed HS, Ghoniem SA. Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre. Lupus. 2015 Mar;24(3):331-8. doi: 10.1177/0961203314567751. Epub 2015 Jan 20.</mixed-citation><mixed-citation xml:lang="en">Mahmoud GA, Zayed HS, Ghoniem SA. Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre. Lupus. 2015 Mar;24(3):331-8. doi: 10.1177/0961203314567751. Epub 2015 Jan 20.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hajji M, Harzallah A, Kaaroud H, et al. Factors associated with relapse of lupus nephritis: a single center study of 249 cases. Saudi J Kidney Dis Transpl. Nov-Dec 2017;28(6): 1349-55. doi: 10.4103/1319-2442.220863.</mixed-citation><mixed-citation xml:lang="en">Hajji M, Harzallah A, Kaaroud H, et al. Factors associated with relapse of lupus nephritis: a single center study of 249 cases. Saudi J Kidney Dis Transpl. Nov-Dec 2017;28(6): 1349-55. doi: 10.4103/1319-2442.220863.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bock M, Heijnen I, Trendelenburg M. Anti-C1q antibodies as a follow-up marker in SLE patients. PLoS One. 2015 Apr 16;10(4): e0123572. doi: 10.1371/journal.pone.0123572. eCollection 2015.</mixed-citation><mixed-citation xml:lang="en">Bock M, Heijnen I, Trendelenburg M. Anti-C1q antibodies as a follow-up marker in SLE patients. PLoS One. 2015 Apr 16;10(4): e0123572. doi: 10.1371/journal.pone.0123572. eCollection 2015.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Akhter E, Burlingame RW, Seaman AL, et al. Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers. Lupus. 2011 Oct;20(12): 1267-74. doi: 10.1177/0961203311411597. Epub 2011 Aug 3.</mixed-citation><mixed-citation xml:lang="en">Akhter E, Burlingame RW, Seaman AL, et al. Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers. Lupus. 2011 Oct;20(12): 1267-74. doi: 10.1177/0961203311411597. Epub 2011 Aug 3.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Pagni F, Galimberti S, Goffredo P, et al. The value of repeat biopsy in the management of lupus nephritis: an international multicentre study in a large cohort of patients. Nephrol Dial Transplant. 2013 Dec;28(12):3014-23. doi: 10.1093/ndt/gft272. Epub 2013 Aug 24.</mixed-citation><mixed-citation xml:lang="en">Pagni F, Galimberti S, Goffredo P, et al. The value of repeat biopsy in the management of lupus nephritis: an international multicentre study in a large cohort of patients. Nephrol Dial Transplant. 2013 Dec;28(12):3014-23. doi: 10.1093/ndt/gft272. Epub 2013 Aug 24.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Malvar A, Pirruccio P, Alberton V, et al. Histologic versus clinical remission in proliferative lupus nephritis. Nephrol Dial Transplant. 2017 Aug 1;32(8):1338-44. doi: 10.1093/ndt/gfv296.</mixed-citation><mixed-citation xml:lang="en">Malvar A, Pirruccio P, Alberton V, et al. Histologic versus clinical remission in proliferative lupus nephritis. Nephrol Dial Transplant. 2017 Aug 1;32(8):1338-44. doi: 10.1093/ndt/gfv296.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">De Rosa M, Azzato F, Toblli JE, et al. A prospective observational cohort study highlights kidney biopsy findings of lupus nephritis patients in remission who flare following withdrawal of maintenance therapy. Kidney Int. 2018 Oct;94(4):788-94. doi: 10.1016/j.kint.2018.05.021. Epub 2018 Jul 23.</mixed-citation><mixed-citation xml:lang="en">De Rosa M, Azzato F, Toblli JE, et al. A prospective observational cohort study highlights kidney biopsy findings of lupus nephritis patients in remission who flare following withdrawal of maintenance therapy. Kidney Int. 2018 Oct;94(4):788-94. doi: 10.1016/j.kint.2018.05.021. Epub 2018 Jul 23.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bertsias GK, Tektonidou M, Amoura Z, et al. Joint European League against rheumatism and European renal AssociationEuropean dialysis and transplant association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012 Nov;71(11): 1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31.</mixed-citation><mixed-citation xml:lang="en">Bertsias GK, Tektonidou M, Amoura Z, et al. Joint European League against rheumatism and European renal AssociationEuropean dialysis and transplant association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012 Nov;71(11): 1771-82. doi: 10.1136/annrheumdis-2012-201940. Epub 2012 Jul 31.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Brouwers MC, Kho ME, Browman GP, et al. AGREE II: advancing Guideline development, reporting and evaluation in health care. CMAJ. 2010 Dec 14;182(18):E839-42. doi: 10.1503/cmaj.090449. Epub 2010 Jul 5.</mixed-citation><mixed-citation xml:lang="en">Brouwers MC, Kho ME, Browman GP, et al. AGREE II: advancing Guideline development, reporting and evaluation in health care. CMAJ. 2010 Dec 14;182(18):E839-42. doi: 10.1503/cmaj.090449. Epub 2010 Jul 5.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Song D, Wu L, Wang F, et al. The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther. 2013 Jan 15;15(1):R12. doi: 10.1186/ar4142.</mixed-citation><mixed-citation xml:lang="en">Song D, Wu L, Wang F, et al. The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther. 2013 Jan 15;15(1):R12. doi: 10.1186/ar4142.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Park MH, Caselman N, Ulmer S, et al. Complement-mediated thrombotic microangiopathy associated with lupus nephritis. Blood Adv. 2018 Aug 28;2(16):2090-94. doi: 10.1182/bloodadvances.2018019596.</mixed-citation><mixed-citation xml:lang="en">Park MH, Caselman N, Ulmer S, et al. Complement-mediated thrombotic microangiopathy associated with lupus nephritis. Blood Adv. 2018 Aug 28;2(16):2090-94. doi: 10.1182/bloodadvances.2018019596.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Чельдиева ФА, Решетняк ТМ, Раденска-Лоповок СГ и др. Антифосфолипидный синдром и системная красная волчанка: какое заболевание является причиной повреждения органов? Научно-практическая ревматология. 2020;58(2):225-31.</mixed-citation><mixed-citation xml:lang="en">Chel'dieva FA, Reshetnyak TM, RadenskaLopovok SG, et al. Antiphospholipid syndrome and systemic lupus erythematosus: what disease causes organ damage? Nauchnoprakticheskaya revmatologiya. 2020;58(2): 225-31. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Yue C, Li G, Wen Y, et al. Early reninangiotensin system blockade improved shortterm and longterm renal outcomes in systemic lupus erythematosus patients with Antiphospholipid-associated nephropathy. J Rheumatol. 2018 May;45(5):655-62. doi: 10.3899/jrheum.170561. Epub 2018 Feb 15.</mixed-citation><mixed-citation xml:lang="en">Yue C, Li G, Wen Y, et al. Early reninangiotensin system blockade improved shortterm and longterm renal outcomes in systemic lupus erythematosus patients with Antiphospholipid-associated nephropathy. J Rheumatol. 2018 May;45(5):655-62. doi: 10.3899/jrheum.170561. Epub 2018 Feb 15.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Andreoli L, Bertsias GK, Agmon-Levin N, et al. EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017 Mar;76(3): 476-85. doi: 10.1136/annrheumdis-2016-209770. Epub 2016 Jul 25.</mixed-citation><mixed-citation xml:lang="en">Andreoli L, Bertsias GK, Agmon-Levin N, et al. EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017 Mar;76(3): 476-85. doi: 10.1136/annrheumdis-2016-209770. Epub 2016 Jul 25.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Кошелева НМ, Матьянова ЕВ, Федорова ЕВ, Клименченко НИ. Исходы беременности у больных ревматоидным артритом и системной красной волчанкой. Часть I. Материнские исходы. Научно-практическая ревматология. 2019;57(2):180-5.</mixed-citation><mixed-citation xml:lang="en">Kosheleva NM, Mat'yanova EV, Fedorova EV, Klimenchenko NI. Pregnancy outcomes in patients with rheumatoid arthritis and systemic lupus erythematosus. Part I. Maternal outcomes. Nauchno-prakticheskaya revmatologiya. 2019;57(2):180-5. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Koh JH, Ko HS, Kwok SK, et al. Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus. Lupus. 2015 Feb;24(2):210-7. doi: 10.1177/0961203314555352. Epub 2014 Oct 10.</mixed-citation><mixed-citation xml:lang="en">Koh JH, Ko HS, Kwok SK, et al. Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus. Lupus. 2015 Feb;24(2):210-7. doi: 10.1177/0961203314555352. Epub 2014 Oct 10.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Koh JH, Ko HS, Lee J, et al. Pregnancy and patients with preexisting lupus nephritis: 15 years of experience at a single center in Korea. Lupus. 2015 Jun;24(7):764-72. doi: 10.1177/0961203315572715. Epub 2015 Feb 23.</mixed-citation><mixed-citation xml:lang="en">Koh JH, Ko HS, Lee J, et al. Pregnancy and patients with preexisting lupus nephritis: 15 years of experience at a single center in Korea. Lupus. 2015 Jun;24(7):764-72. doi: 10.1177/0961203315572715. Epub 2015 Feb 23.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer-Betz R, Specker C, Brinks R, et al. Low risk of renal flares and negative outcomes in women with lupus nephritis Conceiving after switching from mycophenolate mofetil to azathioprine. Rheumatology (Oxford). 2013 Jun;52(6):1070-6. doi: 10.1093/rheumatology/kes425. Epub 2013 Feb 4.</mixed-citation><mixed-citation xml:lang="en">Fischer-Betz R, Specker C, Brinks R, et al. Low risk of renal flares and negative outcomes in women with lupus nephritis Conceiving after switching from mycophenolate mofetil to azathioprine. Rheumatology (Oxford). 2013 Jun;52(6):1070-6. doi: 10.1093/rheumatology/kes425. Epub 2013 Feb 4.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Шилов ЕМ, Смирнов АВ, Козловская НЛ, редакторы. Нефрология. Клинические рекомендации. Москва: ГЭОТАРМедиа; 2016. 816 с.</mixed-citation><mixed-citation xml:lang="en">Shilov EM, Smirnov AV, Kozlovskaya NL, editors. Nefrologiya. Klinicheskie rekomendatsii [Nephrology. Clinical guidelines]. Moscow: GEOTAR-Media; 2016. 816 p.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Национальные рекомендации «Диагностика и лечение нефрита при системной красной волчанке» http://nonr.ru/wpcontent/uploads/2013/11</mixed-citation><mixed-citation xml:lang="en">National guidelines «Diagnosis and treatment of nephritis in systemic lupus erythematosus»]. http://nonr.ru/wpcontent/uploads/2013/11</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Elmougy A, Sarhan A, Hammad A, et al. Lupus nephritis in Egyptian children: a 16- year experience. J Nephrol. 2015 Oct;28(5):557-62. doi: 10.1007/s40620-014-0157-x. Epub 2014 Dec 10.</mixed-citation><mixed-citation xml:lang="en">Elmougy A, Sarhan A, Hammad A, et al. Lupus nephritis in Egyptian children: a 16- year experience. J Nephrol. 2015 Oct;28(5):557-62. doi: 10.1007/s40620-014-0157-x. Epub 2014 Dec 10.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorot FJ, Islabao AG, Pereira RM, et al. Disease presentation of 1312 childhoodonset systemic lupus erythematosus: influence of ethnicity. Clin Rheumatol. 2019 Oct;38(10): 2857-63. doi: 10.1007/s10067-019-04631-0. Epub 2019 Jun 13.</mixed-citation><mixed-citation xml:lang="en">Fiorot FJ, Islabao AG, Pereira RM, et al. Disease presentation of 1312 childhoodonset systemic lupus erythematosus: influence of ethnicity. Clin Rheumatol. 2019 Oct;38(10): 2857-63. doi: 10.1007/s10067-019-04631-0. Epub 2019 Jun 13.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Groot N, de Graeff N, Marks SD, et al. European evidence-based recommendations for the diagnosis and treatment of childhoodonset lupus nephritis: the SHARE initiative. Ann Rheum Dis. 2017 Dec;76(12):1965-73. doi: 10.1136/annrheumdis-2017-211898. Epub 2017 Sep 6.</mixed-citation><mixed-citation xml:lang="en">Groot N, de Graeff N, Marks SD, et al. European evidence-based recommendations for the diagnosis and treatment of childhoodonset lupus nephritis: the SHARE initiative. Ann Rheum Dis. 2017 Dec;76(12):1965-73. doi: 10.1136/annrheumdis-2017-211898. Epub 2017 Sep 6.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mina R, von Scheven E, Ardoin SP, et al. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558.</mixed-citation><mixed-citation xml:lang="en">Mina R, von Scheven E, Ardoin SP, et al. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
