mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2021-1-87-93mrj-1105Research ArticleОБЗОРЫREVIEWSПерспективы использования тромбоцитарной плазмы в терапии ревматоидного артритаProspects for use of platelet-rich plasma in the treatment of rheumatoid arthritishttps://orcid.org/0000-0001-8027-8624МаглеваныйС. В.MaglevaniyS. V.

Сергей Владимирович Маглеваный

115522, Москва, Каширское шоссе, 34А

 

Sergey Vladimirovich Maglevaniy

34A, Kashirskoe Shosse, Moscow 115522

dr.maglevanyy@gmail.comhttps://orcid.org/0000-0001-7622-9678НарышкинЕ. А.NaryshkinE. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0001-7312-2349ЧетинаЕ. В.ChetinaE. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-5626-7404МакаровМ. А.MakarovM. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation2021180220211518793Copyright © Маглеваный С.В., Нарышкин Е.А., Четина Е.В., Макаров М.А., 20212021Маглеваный С.В., Нарышкин Е.А., Четина Е.В., Макаров М.А.Maglevaniy S.V., Naryshkin E.A., Chetina E.V., Makarov M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1105

Представлен обзор данных литературы, посвященной механизмам действия богатой тромбоцитами плазмы (Platelet Rich Plasma, PRP) и опыту ее применения у пациентов с ревматоидным артритом (РА). Определено место PRP в системной и локальной терапии РА. Описаны химический состав PRP и структура включенных в нее органелл тромбоцитов. Дана оценка способов получения тромбоцитарной плазмы, содержащей различные концентрации ключевых факторов роста: тромбоцитарного фактора роста (PDGF), трансформирующего фактора роста α (TGFα), сосудистого эндотелиального фактора роста (VEGF), инсулиноподобного фактора роста (IGF) и эпидермального фактора роста (EGF). Рассмотрены варианты классификаций PRP, которые учитывают различия препаратов по составу и содержанию факторов роста. Проанализирован опыт внутрисуставного введения препаратов аутологичной плазмы пациентам с РА и синовитом. На основании приведенных данных сделано заключение о том, что PRP-терапия может оказаться эффективным инструментом купирования воспаления и стимуляции локальных процессов репарации поврежденных тканей сустава у больных РА. Дальнейшее изучение возможностей применения PRP-терапии и формирование ее протокола при РА позволят оказывать эффективную персонализированную помощь таким больным.

The paper reviews the data available in the literature on the mechanisms of action of platelet-rich plasma (PRP) and the experience of its use in patients with rheumatoid arthritis (RA). It defines the place of PRP in the systemic and local therapy of RA. The chemical composition of PRP and the structure of the platelet organelles included in it are described. An estimate is made for procedures to prepare platelet-rich plasma containing different concentrations of key growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor α (TGFα), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), and epidermal growth factor (EGF). The variants of PRP classifications, which take into account differences in the composition and levels of the growth factors, are considered. The experience with intra-articular injections of autologous plasma products in patients with RA and synovitis is analyzed. These findings lead to the conclusion that PRP therapy can be an effective tool to relieve inflammation and to stimulate local reparative processes in damaged joint tissues in patients with RA. Further study of the possibilities of using this method of therapy and the formation of a PRPtherapy protocol for patients with rheumatoid arthritis will provide effective personalized care to these patients.

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The authors declare that there are no conflicts of interest present.