mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2021-1-105-110mrj-1108Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSАнтиммюллеров гормон при системной красной волчанкеAnti-Mullerian hormone in systemic lupus erythematosushttps://orcid.org/0000-0002-6619-718XАлекбероваЗ. С.AlekberovaZ. S.

Земфира Садуллаевна Алекберова

115522, Москва, Каширское шоссе, 34А

 

Zemfira Sadullaevna Alekberova

34A, Kashirskoe shosse, Moscow 115522

zalekberova@inbox.ruhttps://orcid.org/0000-0002-4846-5531ЕгороваО. Н.EgorovaO. N.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522

https://orcid.org/0000-0002-3139-8811ГолоеваР. Г.GoloevaR. G.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522

https://orcid.org/0000-0002-5253-371XЧеркасоваМ. В.CherkasovaM. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202118022021151105110Copyright © Алекберова З.С., Егорова О.Н., Голоева Р.Г., Черкасова М.В., 20212021Алекберова З.С., Егорова О.Н., Голоева Р.Г., Черкасова М.В.Alekberova Z.S., Egorova O.N., Goloeva R.G., Cherkasova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1108

В настоящее время при системной красной волчанке (СКВ) все большее внимание уделяется изучению овариального резерва, который может служить одним из показателей благоприятного ответа на терапию и планирования беременности. С этой целью в качестве наиболее чувствительного маркера, отражающего непрерывный рост мелких фолликулов, рассматривается антимюллеров гормон (AMГ). В статье приведены данные литературы о взаимосвязи сывороточного уровня гормона с возрастом, этнической принадлежностью, массой тела, активностью заболевания и проводимой терапией. Представлены три клинических наблюдения женщин детородного возраста с СКВ, разными длительностью болезни и суммарной дозой базисных противовоспалительных препаратов, у которых был определен уровень АМГ в сыворотке крови.

Currently, in patients with systemic lupus erythematosus (SLE) increasing attention is paid to the ovarian reserve evaluation, which can serve as one of the markers of a favorable response to therapy and pregnancy planning. For this purpose, anti-Mullerian hormone (AMH) is considered as the most sensitive marker, that reflect the continuous growth of small follicles. The article presents data on the relationship of serum hormone levels with age, ethnicity, body weight, disease activity, and therapy. We present clinical cases of three women of childbearing age with SLE, different duration of the disease and cumulative dose of disease-modifying antirheumatic drugs in whom the level of AMH in the blood serum was measured.

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The authors declare that there are no conflicts of interest present.