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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2021-1-111-118</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Применение эторикоксиба при генерализованном остеоартрите. Описание клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Etoricoxib for generalized osteoarthritis. Case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2985-8831</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дыдыкина</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Dydykina</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Степановна Дыдыкина</p><p>115522, Москва, Каширское шоссе, 34А</p><p> </p></bio><bio xml:lang="en"><p>Irina Stepanovna Dydykina</p><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><email xlink:type="simple">dydykina_is@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6076-4374</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваленко</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalenko</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1084-3920</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудинский</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudinsky</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>02</month><year>2021</year></pub-date><volume>15</volume><issue>1</issue><fpage>111</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дыдыкина И.С., Коваленко П.С., Кудинский Д.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Дыдыкина И.С., Коваленко П.С., Кудинский Д.М.</copyright-holder><copyright-holder xml:lang="en">Dydykina I.S., Kovalenko P.S., Kudinsky D.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1109">https://mrj.ima-press.net/mrj/article/view/1109</self-uri><abstract><p>В статье обсуждается лечение пациентов с первичным генерализованным остеоартритом (ОА), распространенным поражением суставов разной локализации. Представлены клинические рекомендации, которые содержат указания на различные медикаментозные и немедикаментозные подходы к лечению первичного генерализованного ОА. В соответствии с современным пониманием патогенеза ОА, роли воспаления и влияния различных провоспалительных факторов обоснована приоритетность противовоспалительной терапии, прежде всего нестероидными противовоспалительными препаратами. Описана пациентка с первичным генерализованным ОА и низкой приверженностью лечению симптоматическими медленно действующими препаратами, которую авторы наблюдали в течение 5 лет. При обострении суставного синдрома в качестве болеутоляющего и противовоспалительного средства использовался преимущественно эторикоксиб (Костарокс®) в дозе 60 мг/сут в течение 7–14 дней с хорошим эффектом. На фоне самоизоляции и невозможности посетить врача в условиях пандемии COVID-19 изза интенсивной боли в шейном и поясничном отделах позвоночника пациентка длительно (до 200 дней) принимала эторикоксиб, при этом продолжительность отдельных курсов достигала 3 мес. Обсуждается возможность использования эторикоксиба не только в режиме «по требованию», но и длительно – до достижения эффекта.</p></abstract><trans-abstract xml:lang="en"><p>The article discusses the treatment of patients with primary generalized osteoarthritis (OA), a common joint lesion of different localization. Clinical guidelines are presented that provide guidance on various drug and non-drug approaches in the treatment of primary generalized OA. In accordance with the modern understanding of the pathogenesis of OA, the role of inflammation and the influence of various pro-inflammatory factors, the priority of anti-inflammatory therapy, primarily non-steroidal anti-inflammatory drugs (NSAIDs), is justified. A clinical case of a 5-year observation of a patient with primary generalized OA and low compliance to treatment with symptom-modifying slowacting drugs is described. For articular syndrome exacerbations etoricoxib (Kostarox®) was mainly used as an analgesic and anti-inflammatory agent at a dose of 60 mg / day for 7–14 days with a good effect. Due to self-isolation and inability to visit a doctor during COVID-19 pandemic, the patient took etoricoxib for a long time (up to 200 days) for severe neck- and backpain relief, the duration of some courses was up to3 months. We discuss the possibility of etoricoxib use not only in the «on demand» mode, but also for a long time – until the effect is achieved.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первичный генерализованный остеоартрит</kwd><kwd>остеоартрит коленных суставов</kwd><kwd>остеоартрит тазобедренных суставов</kwd><kwd>эторикоксиб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary generalized osteoarthritis</kwd><kwd>knee osteoarthritis</kwd><kwd>hip osteoarthritis</kwd><kwd>etoricoxib</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья спонсируется компанией «Сандоз»</funding-statement><funding-statement xml:lang="en">This article has been supported by Sandoz</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Галушко ЕА, Большакова ТВ, Виноградова ИБ и др. 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