<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2021-3-111-116</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1158</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОНСЕНСУС ЭКСПЕРТОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERT CONSENSUS</subject></subj-group></article-categories><title-group><article-title>Комплексный подход к выбору терапии у пациентов с остеоартритом при первичном обращении к врачу. Консенсус экспертов (обзор литературы и резолюция)</article-title><trans-title-group xml:lang="en"><trans-title>Comprehensive approach to the choice of therapy in patients with osteoarthritis at the first visit to the doctor. Expert consensus (literature review and resolution)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Михайлович Лила</p><p>Россия, 115522, Москва, Каширское шоссе, 34А</p><p>Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Alexander Mikhailovich Lila</p><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p><p>22/1, Barrikadnaya Str., Build. 1, Moscow 125993, Russia</p></bio><email xlink:type="simple">amlila@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1, Ostrovitianov Str., Moscow 117997, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8255-5645</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яхно</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakhno</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 119991, Москва, ул. Трубецкая, 8, стр. 2</p></bio><bio xml:lang="en"><p>8, Trubetskaya Str., Build. 2, Moscow 119991, Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6253-621X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1, Ostrovitianov Str., Moscow 117997, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7017-0898</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А</p><p>Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p><p>22/1, Barrikadnaya Str., Build. 1, Moscow 125993, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1628-5093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1, Ostrovitianov Str., Moscow 117997, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8655-8501</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Путилина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Putilina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>1, Ostrovitianov Str., Moscow 117997, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кукушкин</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukushkin</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 125315, Москва, Балтийская ул., 8</p></bio><bio xml:lang="en"><p>8, Baltiyskaya Str., Moscow 125315, Russia</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2466-7120</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочиш</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochish</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 195427, Санкт-Петербург, ул. Академика Байкова, 8</p></bio><bio xml:lang="en"><p>8, Akademika Baykova Str., St. Petersburg 195427, Russia</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8218-3223</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таскина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Taskina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522, Russia</p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6146-2706</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абузарова</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abuzarova</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>3, 2nd Botkinskiy proezd, Moscow 125284, Russia</p></bio><xref ref-type="aff" rid="aff-7"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology; Department of rheumatology, Russian Medical Academy of Continuing Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>4ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov Unoversity)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт общей патологии и патофизиологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Institute of general pathology and pathophysiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Р.Р. Вредена» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden Russian Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.Hertsen Moscow Oncology Research Institute – affiliated branch of National Medical Research Radiological Center of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2021</year></pub-date><volume>15</volume><issue>3</issue><fpage>111</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лила А.М., Ткачева О.Н., Яхно Н.Н., Наумов А.В., Алексеева Л.И., Котовская Ю.В., Путилина М.В., Кукушкин М.Л., Кочиш А.Ю., Таскина Е.А., Абузарова Г.Р., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Лила А.М., Ткачева О.Н., Яхно Н.Н., Наумов А.В., Алексеева Л.И., Котовская Ю.В., Путилина М.В., Кукушкин М.Л., Кочиш А.Ю., Таскина Е.А., Абузарова Г.Р.</copyright-holder><copyright-holder xml:lang="en">Lila A.M., Tkacheva O.N., Yakhno N.N., Naumov A.V., Alekseeva L.I., Kotovskaya Y.V., Putilina M.V., Kukushkin M.L., Kochish A.Y., Taskina E.A., Abuzarova G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1158">https://mrj.ima-press.net/mrj/article/view/1158</self-uri><abstract><p>Остеоартрит (ОА) – наиболее распространенная патология опорно-двигательного аппарата, являющаяся серьезной медико-социальной проблемой. Особое значение ОА приобретает у лиц пожилого и старческого возраста из-за высокой частоты коморбидной патологии. Купирование болевого синдрома является приоритетным при формировании индивидуальных терапевтических программ для пациентов с ОА, начиная с момента их первичного обращения за медицинской помощью. Вместе с тем из-за неоднозначности существующих клинических рекомендаций большинство экспертов отмечают ряд сложностей при назначении лечения больным ОА.</p><p>В статье представлена согласованная позиция экспертов, касающаяся комплексного подхода к выбору терапии у пациентов с ОА при первичном обращении к врачу. Рассмотрены имеющиеся на сегодняшний день клинические рекомендации по ведению пациентов с ОА, наиболее часто возникающие проблемы при курации больных ОА в реальной клинической практике, цели лечебных стратегий при ОА с учетом факторов риска его прогрессирования, алгоритм лечения боли у пациентов с ОА при первичном обращении и профилактики обострений ОА с использованием базисных структурно-модифицирующих препаратов, рекомендации по выбору нестероидных противовоспалительных препаратов.</p><p>По мнению экспертов, рациональный подход к терапии ОА основан на комбинированном использовании немедикаментозных и фармакологических методов при постоянном мониторинге режимов терапии и побочных эффектов. Данные рекомендации можно рассматривать как болезнь-модифицирующие стратегии, позволяющие во многих случаях улучшить функциональный статус и добиться длительной ремиссии у пациентов с ОА.</p></abstract><trans-abstract xml:lang="en"><p>Osteoarthritis (OA) is the most common pathology of the musculoskeletal system and is a serious medical and social problem. OA is of particular importance in elderly and senile people due to the high frequency of comorbid pathology. Pain relief is a priority in the formation of individual therapeutic programs for patients with OA, starting from their first request for medical assistance. At the same time, due to the ambiguity of existing clinical recommendations, most experts note a number of difficulties in prescribing treatment for patients with OA.</p><p>The article presents a consensus position of experts regarding a complex approach to the choice of therapy in patients with OA at the initial visit to the doctor. The article discusses: current clinical guidelines for the management of patients with OA; most common problems in the management of patients with OA in real clinical practice; goals of treatment strategies for OA taking into account the risk factors for its progression; an algorithm of pain relief during initial treatment in patients with OA; prevention of OA exacerbations with the use of basic structure-modifying drugs; recommendations for the choice of non-steroidal anti-inflammatory drugs.</p><p>According to experts, a rational approach to the treatment of OA is based on the combined use of non-drug and pharmacological methods with constant monitoring of therapy regimens and side effects. These recommendations can be considered disease-modifying strategies that in many cases allow improving functional status and achieving long-term remission in patients with OA.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>боль</kwd><kwd>лечебные стратегии</kwd><kwd>комплексный подход</kwd><kwd>рекомендации экспертов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>pain</kwd><kwd>treatment strategies</kwd><kwd>complex approach</kwd><kwd>expert recommendations</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья спонсируется компанией STADA</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ЛИ, Таскина ЕА, Кашеварова НГ. Остеоартрит: эпидемиология, классификация, факторы риска и прогрессирования, клиника, диагностика, лечение. Современная ревматология. 2019;13(2): 9-21.</mixed-citation><mixed-citation xml:lang="en">Alekseeva LI, Taskina EA, Kashevarova NG. Osteoarthritis: epidemiology, classification, risk factors, and progression, clinical presentation, diagnosis, and treatment. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2019;13(2):9-21. (In Russ.). doi: 10.14412/1996-7012-2019-2-9-21</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hunter DJ, March L, Chew M. Osteoarthritis in 2020 and beyond: a Lancet Commission. Lancet. 2020 Nov 28;396(10264): 1711-12. doi: 10.1016/S0140-6736(20)32230-3. Epub 2020 Nov 4.</mixed-citation><mixed-citation xml:lang="en">Hunter DJ, March L, Chew M. Osteoarthritis in 2020 and beyond: a Lancet Commission. Lancet. 2020 Nov 28;396(10264): 1711-12. doi: 10.1016/S0140-6736(20)32230-3. Epub 2020 Nov 4.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Meessen JMTA, Leichtenberg CS, Tilbury C, et al. Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire. Rheumatol Int. 2018 May;38(5):917-24. doi: 10.1007/s00296-017-3868-1. Epub 2017 Nov 17.</mixed-citation><mixed-citation xml:lang="en">Meessen JMTA, Leichtenberg CS, Tilbury C, et al. Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire. Rheumatol Int. 2018 May;38(5):917-24. doi: 10.1007/s00296-017-3868-1. Epub 2017 Nov 17.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Macfarlane GJ, Barnish MS, Jones GT. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 Nov;76(11):1815-22. doi: 10.1136/annrheumdis-2017-211476. Epub 2017 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Macfarlane GJ, Barnish MS, Jones GT. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 Nov;76(11):1815-22. doi: 10.1136/annrheumdis-2017-211476. Epub 2017 Jul 21.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">de Rooij M, van der Leeden M, Heymans MW, et al. Prognosis of Pain and Physical Functioning in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2016 Apr;68(4):481-92. doi: 10.1002/acr.22693.</mixed-citation><mixed-citation xml:lang="en">de Rooij M, van der Leeden M, Heymans MW, et al. Prognosis of Pain and Physical Functioning in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2016 Apr;68(4):481-92. doi: 10.1002/acr.22693.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Кашеварова НГ, Зайцева ЕМ, Смирнов АВ, Алексеева ЛИ. Боль как один из факторов риска прогрессирования остео- артроза коленных суставов. Научно-практическая ревматология. 2013;51(4):387-90.</mixed-citation><mixed-citation xml:lang="en">Kashevarova NG, Zaitseva EM, Smirnov AV, Alekseeva LI. Pain as one of the risk factors for the progression of osteoarthritis of the knee joints. Nauchno-prakticheskaya revmatologiya. 2013;51(4):387-90. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation><mixed-citation xml:lang="en">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kolasinski SL, Neogi T, Hochberg MC et al. 2019 American College of Rheumatology/ Arthritis Foundation Guideline for the Manage-ment of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62. doi: 10.1002/acr.24131. Epub 2020 Jan 6.</mixed-citation><mixed-citation xml:lang="en">Kolasinski SL, Neogi T, Hochberg MC et al. 2019 American College of Rheumatology/ Arthritis Foundation Guideline for the Manage-ment of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62. doi: 10.1002/acr.24131. Epub 2020 Jan 6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppenburg M, Kroon FB, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019 Jan;78(1): 16-24. doi: 10.1136/annrheumdis-2018-213826. Epub 2018 Aug 28.</mixed-citation><mixed-citation xml:lang="en">Kloppenburg M, Kroon FB, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019 Jan;78(1): 16-24. doi: 10.1136/annrheumdis-2018-213826. Epub 2018 Aug 28.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации «Хроническая боль у пациентов пожилого и старческого возраста». https://legalacts.ru/doc/klinicheskierekomendatsii-khronicheskaja-bol-u-patsientov-pozhilogo-i-starcheskogo/</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations «Chronic pain in elderly and senile patients». https://legalacts.ru/doc/klinicheskierekomendatsii-khronicheskaja-bol-u-patsientov-pozhilogo-i-starcheskogo/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации «Остеоартроз», Общероссийская общественная организация «Ассоциация ревматологов России», 2016. https://pharmspb.ru/docs/lit/Revmatologia_Rekomendazii%20po%20diagnostike%20i%20lecheniyu%20osteoartroza%20(MZ%20RF,%202016).pdf</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations «Osteoarthritis», All-Russian public organization «Association of Rheumatologists of Russia», 2016. https://pharmspb.ru/docs/lit/Revmatologia_Rekomendazii%20po%20diagnostike%20i%20lecheniyu%20osteoartroza%20(MZ%20RF,%202016).pdf</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ЛИ, Наумов АВ. Ведение остеоартрита с коморбидностью в общей врачебной практике (клинические рекомендации). Доктор.Ру. 2017;(5):51-69.</mixed-citation><mixed-citation xml:lang="en">Alekseeva LI, Naumov AV. Management of osteoarthritis with comorbidity in general medical practice (clinical recommendations). Doktor.Ru. 2017;(5):51-69. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bastick AN, Runhaar J, Belo JN, et al. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015 Jun 8;17(1):152. doi: 10.1186/s13075-015-0670-x.</mixed-citation><mixed-citation xml:lang="en">Bastick AN, Runhaar J, Belo JN, et al. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015 Jun 8;17(1):152. doi: 10.1186/s13075-015-0670-x.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Leyland KM, Gates LS, Sanchez- Santos MT, et al. Knee osteoarthritis and time-to all-cause mortality in six communitybased cohorts: an international meta-analysis of individual participant-level data. Aging Clin Exp Res. 2021 Mar;33(3):529-45. doi: 10.1007/s40520-020-01762-2. Epub 2021 Feb 15.</mixed-citation><mixed-citation xml:lang="en">Leyland KM, Gates LS, Sanchez- Santos MT, et al. Knee osteoarthritis and time-to all-cause mortality in six communitybased cohorts: an international meta-analysis of individual participant-level data. Aging Clin Exp Res. 2021 Mar;33(3):529-45. doi: 10.1007/s40520-020-01762-2. Epub 2021 Feb 15.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Путилина МВ. Коморбидность у пациентов пожилого возраста. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(5):106-11.</mixed-citation><mixed-citation xml:lang="en">Putilina MV. Comorbidity in elderly patients. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(5):106-11. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно НН, Кукушкин МЛ, Чурюканов МВ и др. Новое определение боли Международной ассоциации по изучению боли. Российский журнал боли. 2020; 18(4):5-7.</mixed-citation><mixed-citation xml:lang="en">Yakhno NN, Kukushkin ML, Churyukanov MV, et al. New Definition of Pain by the International Association for the Study of Pain. Rossiiskii zhurnal boli. 2020;18(4):5-7. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Бахтадзе МА, Чурюканов МВ, Кукушкин МЛ и др. Опросник для оценки центральной сенситизации: лингвистическая адаптация русскоязычной версии. Российский журнал боли. 2020;18(4):40-5.</mixed-citation><mixed-citation xml:lang="en">Bakhtadze MA, Churyukanov MV, Kukushkin ML, et al. Questionnaire for assessing central sensitization: linguistic adaptation of the Russian version. Russian Journal of Pain. Rossiiskii zhurnal boli. 2020;18(4):40-5. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачева ОН, редактор. Методические рекомендации. В помощь пожилому человеку и его близким: физическая активность в пожилом возрасте. Москва: Прометей; 2019. 62 с.</mixed-citation><mixed-citation xml:lang="en">Tkacheva ON, editor. Metodicheskie rekomendatsii. V pomoshch' pozhilomu cheloveku i ego blizkim: fizicheskaya aktivnost' v pozhilom vozraste [Methodological recommendations. To help the elderly and their loved ones: physical activity in old age]. Moscow: Prometei; 2019. 62 p.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Beaudart C, Lengele L, Leclercq V, et al. Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon. Drugs. 2020 Dec;80(18):1947-59. doi: 10.1007/s40265-020-01423-8.</mixed-citation><mixed-citation xml:lang="en">Beaudart C, Lengele L, Leclercq V, et al. Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon. Drugs. 2020 Dec;80(18):1947-59. doi: 10.1007/s40265-020-01423-8.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yang W, Sun C, He SQ, et al. The Efficacy and Safety of Disease- Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis – a Systematic Review and Network Meta-Analysis. J Gen Intern Med. 2021 Apr 12. doi: 10.1007/s11606-021-06755-z. Online ahead of print.</mixed-citation><mixed-citation xml:lang="en">Yang W, Sun C, He SQ, et al. The Efficacy and Safety of Disease- Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis – a Systematic Review and Network Meta-Analysis. J Gen Intern Med. 2021 Apr 12. doi: 10.1007/s11606-021-06755-z. Online ahead of print.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation><mixed-citation xml:lang="en">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Каратеев АЕ, Насонов ЕЛ, Ивашкин ВТ и др. Рациональное использование нестероидных противовоспалительных препаратов. Клинические рекомендации. Научно-практическая ревматология. 2018; 56(S1):1-29.</mixed-citation><mixed-citation xml:lang="en">Karateev AE, Nasonov EL, Ivashkin VT, et al. Rational use of nonsteroidal anti-inflammatory drugs. Clinical guidelines. Nauchno-prakticheskaya revmatologiya. 2018;56(S1):1-29. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pruss TP, Stroissnig H, Radnofer-Welte S, et al. Overview of the pharmacological properties, pharma – cokinetics and animal safety assessment of lornoxicam. Postgrad Med J. 1990;66 Suppl 4:S18-21.</mixed-citation><mixed-citation xml:lang="en">Pruss TP, Stroissnig H, Radnofer-Welte S, et al. Overview of the pharmacological properties, pharma – cokinetics and animal safety assessment of lornoxicam. Postgrad Med J. 1990;66 Suppl 4:S18-21.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rose P, Steinhauser C. Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig. 2004;24(4):227-36. doi: 10.2165/00044011-200424040-00004.</mixed-citation><mixed-citation xml:lang="en">Rose P, Steinhauser C. Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig. 2004;24(4):227-36. doi: 10.2165/00044011-200424040-00004.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Parada L, Marstein JP, Danilov A. Tolerability of the COX-1/COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic pain. Pain Manag. 2016 Oct;6(5): 445-54. doi: 10.2217/pmt.16.7. Epub 2016 Apr 18.</mixed-citation><mixed-citation xml:lang="en">Parada L, Marstein JP, Danilov A. Tolerability of the COX-1/COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic pain. Pain Manag. 2016 Oct;6(5): 445-54. doi: 10.2217/pmt.16.7. Epub 2016 Apr 18.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
