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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2021-6-26-32</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1223</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Оценка влияния хронической боли на функциональный и физический статус пациентов старших возрастных групп</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the effect of chronic pain on the functional and physical status of patients in older age groups</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6253-621X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра болезней старения, Москва 117997, ул. Островитянова 1;</p><p>ОСП «Российский геронтологический научно-клинический центр», 129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Department of age-related diseases, 1, Ostrovitianov street, Moscow 117997;</p><p>Russian Gerontological Research and Clinical Center, 16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2196-1068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маневич</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manevich</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОСП «Российский геронтологический научно-клинический центр»,</p><p>129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Russian Gerontological Research and Clinical Center,</p><p>16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3066-4866</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ховасова</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Khovasova</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра болезней старения, Москва 117997, ул. Островитянова 1;</p><p>ОСП «Российский геронтологический научно-клинический центр», 129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Department of age-related diseases, 1, Ostrovitianov street, Moscow 117997;</p><p>Russian Gerontological Research and Clinical Center, 16, 1st Leonov street, Moscow 129226</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6040-1090</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мороз</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Moroz</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОСП «Российский геронтологический научно-клинический центр»,</p><p>129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Russian Gerontological Research and Clinical Center,</p><p>16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5187-0108</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мешков</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshkov</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОСП «Российский геронтологический научно-клинический центр»,</p><p>129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Russian Gerontological Research and Clinical Center,</p><p>16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9837-4224</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деменок</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demenok</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОСП «Российский геронтологический научно-клинический центр»,</p><p>129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Russian Gerontological Research and Clinical Center,</p><p>16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3485-3664</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малышева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malysheva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОСП «Российский геронтологический научно-клинический центр»,</p><p>129226, Москва, ул. 1-я Леонова, 16</p></bio><bio xml:lang="en"><p>Russian Gerontological Research and Clinical Center,</p><p>16, 1st Leonov street, Moscow 129226</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2021</year></pub-date><volume>15</volume><issue>6</issue><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Наумов А.В., Маневич Т.М., Ховасова Н.О., Мороз В.И., Мешков А.Д., Деменок Д.В., Малышева А.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Наумов А.В., Маневич Т.М., Ховасова Н.О., Мороз В.И., Мешков А.Д., Деменок Д.В., Малышева А.А.</copyright-holder><copyright-holder xml:lang="en">Naumov A.V., Manevich T.M., Khovasova N.O., Moroz V.I., Meshkov A.D., Demenok D.V., Malysheva A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1223">https://mrj.ima-press.net/mrj/article/view/1223</self-uri><abstract><p>Цель исследования – оценка структуры и влияния хронической боли (ХБ) на функциональный статус пациентов с гериатрическими синдромами.</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. В исследование включено 370 гериатрических пациентов, которые были распределены в две группы. В группу А вошли 300 больных (средний возраст 75,1±8,25 года) с ХБ, а в группу В – 70 лиц сопоставимого возраста (75,1±7,75 года) без ХБ. У всех участников исследования выявлена полиморбидность: индекс Charlson составил 5,55±1,59 балла в группе А и 5,56±1,64 балла в группе В (р=0,963). Всем пациентам проводилась комплексная гериатрическая оценка (КГО) для определения функционального статуса и диагностики гериатрических синдромов.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. По данным КГО синдром старческой астении выявлен у 127 (42,3%) пациентов с ХБ и у 20 (28,6%) без ХБ (р=0,035). Среднее число гериатрических синдромов в группе А равнялось 7,06±2,68, в группе В – 5,2±1,8 (р&lt;0,001).</p><p>Пациенты группы А отличались от лиц без ХБ существенно большей степенью зависимости в повседневной жизни (индекс Бартел) и более низким баллом батареи тестов физического функционирования.</p></sec><sec><title>Заключение</title><p>Заключение. У пациентов с ХБ установлены худшее физическое функционирование и большая степень зависимости от окружающих в повседневной жизни. При планировании наиболее эффективных комплексных стратегий лечения и предупреждения обострений ХБ необходимо учитывать функциональный статус пожилых пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to assess the structure and influence of chronic pain (CP) on the functional status of patients with geriatric syndromes.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The study included 370 geriatric patients who were divided into two groups. Group A included 300 patients (mean age 75.1±8.25 years) with CP, and group B – 70 subjects of comparable age (75.1±7.75 years) without CP. All study participants were found to have polymorbidity: the Charlson index was 5.55±1.59 points in group A and 5.56±1.64 points in group B (p=0.963). All patients underwent a comprehensive geriatric assessment (CGE) to determine the functional status and diagnose geriatric syndromes.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. According to the CGE data, senile asthenia syndrome was detected in 127 (42.3%) patients with CP and in 20 (28.6%) patients without CP (p=0.035). The average number of geriatric syndromes in group A was 7.06±2.68, in group B – 5.2±1.8 (p&lt;0.001).</p><p>Group A patients differed from those without CP in a significantly higher degree of dependence in daily life (Bartel index) and a lower score on the Physical Performance Battery.</p></sec><sec><title>Conclusion</title><p>Conclusion. Patients with CP have poorer physical functioning and a greater degree of dependence on others in their daily life. When planning the most effective complex strategies for the treatment and prevention of CP exacerbations, it is necessary to take into account the functional status of elderly patients. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая боль</kwd><kwd>гериатрический синдром</kwd><kwd>функциональный статус</kwd><kwd>пожилой пациент</kwd><kwd>остеоартрит</kwd><kwd>хондроитина сульфат</kwd><kwd>комплексная гериатрическая оценка</kwd><kwd>саркопения</kwd><kwd>падения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic pain</kwd><kwd>geriatric syndrome</kwd><kwd>functional status</kwd><kwd>elderly patient</kwd><kwd>osteoarthritis</kwd><kwd>chondroitin sulfate</kwd><kwd>comprehensive geriatric assessment</kwd><kwd>sarcopenia</kwd><kwd>falling</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках Государственного задания «Оптимизация диагностики и ведения сочетанных заболеваний опорно-двигательного аппарата у пациентов пожилого и старческого возраста с целью сохранения автономности» (№69.7-2021).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Domenichiello AF, Ramsden CE. The silent epidemic of chronic pain in older adults. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:284-90. doi: 10.1016/j.pnpbp.2019.04.006. Epub 2019 Apr 17.</mixed-citation><mixed-citation xml:lang="en">Domenichiello AF, Ramsden CE. The silent epidemic of chronic pain in older adults. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:284-90. doi: 10.1016/j.pnpbp.2019.04.006. Epub 2019 Apr 17.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pitcher MH, von Korff M, Bushnell MC, Porter L. Prevalence and Profile of HighImpact Chronic Pain in the United States. J Pain. 2019 Feb;20(2):146-60. doi: 10.1016/j.jpain.2018.07.006. Epub 2018 Aug 7.</mixed-citation><mixed-citation xml:lang="en">Pitcher MH, von Korff M, Bushnell MC, Porter L. Prevalence and Profile of HighImpact Chronic Pain in the United States. J Pain. 2019 Feb;20(2):146-60. doi: 10.1016/j.jpain.2018.07.006. Epub 2018 Aug 7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Paeck T, Ferreira ML, Sun C, et al. Are older adults missing from low back pain clinical trials? A systematic review and metaanalysis. Arthritis Care Res (Hoboken). 2014 Aug;66(8):1220-6. doi: 10.1002/acr.22261.</mixed-citation><mixed-citation xml:lang="en">Paeck T, Ferreira ML, Sun C, et al. Are older adults missing from low back pain clinical trials? A systematic review and metaanalysis. Arthritis Care Res (Hoboken). 2014 Aug;66(8):1220-6. doi: 10.1002/acr.22261.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">McLachlan AJ,Bath S, Naganathan V, et al. Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol. 2011 Mar;71(3):351-64. doi: 10.1111/j.1365-2125.2010.03847.x.</mixed-citation><mixed-citation xml:lang="en">McLachlan AJ,Bath S, Naganathan V, et al. Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. Br J Clin Pharmacol. 2011 Mar;71(3):351-64. doi: 10.1111/j.1365-2125.2010.03847.x.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Macfarlane GJ, Barnish MS, Jones GT. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 Nov;76(11):1815-22. doi: 10.1136/annrheumdis-2017-211476. Epub 2017 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Macfarlane GJ, Barnish MS, Jones GT. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 Nov;76(11):1815-22. doi: 10.1136/annrheumdis-2017-211476. Epub 2017 Jul 21.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Whitlock EL, Diaz-Ramirez LG, Glymour MM, et al. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017 Aug 1;177(8):1146-53. doi: 10.1001/jamainternmed.2017.1622.</mixed-citation><mixed-citation xml:lang="en">Whitlock EL, Diaz-Ramirez LG, Glymour MM, et al. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017 Aug 1;177(8):1146-53. doi: 10.1001/jamainternmed.2017.1622.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cole LJ, Farrell MJ, Duff EP, et al. Pain sensitivity and fMRI pain-related brain activity in Alzheimer’s disease. Brain. 2006 Nov; 129(Pt 11):2957-65. doi: 10.1093/brain/awl228. Epub 2006 Sep 2.</mixed-citation><mixed-citation xml:lang="en">Cole LJ, Farrell MJ, Duff EP, et al. Pain sensitivity and fMRI pain-related brain activity in Alzheimer’s disease. Brain. 2006 Nov; 129(Pt 11):2957-65. doi: 10.1093/brain/awl228. Epub 2006 Sep 2.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rajkumar AP, Ballard C, Fossey J, et al. Epidemiology of pain in people with dementia living in care homes: longitudinal course, prevalence, and treatment implications. J Am Med Dir Assoc. 2017 May 1;18(5):453.e1- 453.e6. doi: 10.1016/j.jamda.2017.01.024. Epub 2017 Mar 18.</mixed-citation><mixed-citation xml:lang="en">Rajkumar AP, Ballard C, Fossey J, et al. Epidemiology of pain in people with dementia living in care homes: longitudinal course, prevalence, and treatment implications. J Am Med Dir Assoc. 2017 May 1;18(5):453.e1- 453.e6. doi: 10.1016/j.jamda.2017.01.024. Epub 2017 Mar 18.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачева ОН, Котовская ЮВ, Рунихина НК и др. Клинические рекомендации «Старческая астения». Российский журнал гериатрической медицины. 2020; (1):11-46.</mixed-citation><mixed-citation xml:lang="en">Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical recommendations «Senile asthenia». Rossiiskii zhurnal geriatricheskoi meditsiny. 2020;(1):11-46. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma PK, Reddy BM, Ganguly E. Frailty Syndrome among oldest old Individuals, aged ≥80 years: Prevalence &amp; Correlates. J Frailty Sarcopenia Falls. 2020 Dec 1;5(4):92-101. doi: 10.22540/JFSF-05- 092. eCollection 2020 Dec.</mixed-citation><mixed-citation xml:lang="en">Sharma PK, Reddy BM, Ganguly E. Frailty Syndrome among oldest old Individuals, aged ≥80 years: Prevalence &amp; Correlates. J Frailty Sarcopenia Falls. 2020 Dec 1;5(4):92-101. doi: 10.22540/JFSF-05- 092. eCollection 2020 Dec.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zis P, Daskalaki A, Bountouni I, et al. Depression and chronic pain in the elderly: links and management challenges. Clin Interv Aging. 2017 Apr 21;12:709-20. doi: 10.2147/CIA.S113576. eCollection 2017.</mixed-citation><mixed-citation xml:lang="en">Zis P, Daskalaki A, Bountouni I, et al. Depression and chronic pain in the elderly: links and management challenges. Clin Interv Aging. 2017 Apr 21;12:709-20. doi: 10.2147/CIA.S113576. eCollection 2017.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Patel KV, Guralnik JM, Dansie EJ, Turk DC. Prevalence and impact of pain among older adults in the United States: findings from the 2011 National Health and Aging Trends Study. Pain. 2013 Dec;154(12): 2649-57. doi: 10.1016/j.pain.2013.07.029.</mixed-citation><mixed-citation xml:lang="en">Patel KV, Guralnik JM, Dansie EJ, Turk DC. Prevalence and impact of pain among older adults in the United States: findings from the 2011 National Health and Aging Trends Study. Pain. 2013 Dec;154(12): 2649-57. doi: 10.1016/j.pain.2013.07.029.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Liberman O, Freud T, Peleg R, et al. Chronic pain and geriatric syndromes in community-dwelling patients aged ≥65 years. J Pain Res. 2018 Jun 19;11:1171-80. doi: 10.2147/JPR.S160847.</mixed-citation><mixed-citation xml:lang="en">Liberman O, Freud T, Peleg R, et al. Chronic pain and geriatric syndromes in community-dwelling patients aged ≥65 years. J Pain Res. 2018 Jun 19;11:1171-80. doi: 10.2147/JPR.S160847.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева НМ, Ховасова НО, Ткачева ОН и др. Падения и переломы у лиц старше 65 лет и их ассоциации с гериатрическими синдромами: данные российского эпидемиологического исследования ЭВКАЛИПТ. Российский журнал гериатрической медицины. 2021;2(6):209-19.</mixed-citation><mixed-citation xml:lang="en">Vorob'eva NM, Khovasova NO, Tkacheva ON, et al. Falls and fractures in persons over 65 years of age and their associations with geriatric syndromes: data from the Russian epidemiological study EUCALYPTUS. Rossiiskii zhurnal geriatricheskoi meditsiny. 2021;2(6):209-19. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hana S, Aicha BT, Selim D, et al. Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients. Curr Rheumatol Rev. 2018;14(2):181-7. doi: 10.2174/1573397113666170425150133.</mixed-citation><mixed-citation xml:lang="en">Hana S, Aicha BT, Selim D, et al. Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients. Curr Rheumatol Rev. 2018;14(2):181-7. doi: 10.2174/1573397113666170425150133.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Thinuan P, Siviroj P, Lerttrakarnnon P, Lorga T. Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A CrossSectional Study. Int J Environ Res Public Health. 2020 Jun 8;17(11):4077. doi: 10.3390/ijerph17114077.</mixed-citation><mixed-citation xml:lang="en">Thinuan P, Siviroj P, Lerttrakarnnon P, Lorga T. Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A CrossSectional Study. Int J Environ Res Public Health. 2020 Jun 8;17(11):4077. doi: 10.3390/ijerph17114077.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Marshall LM, Litwack-Harrison S, Cawthon PM, et al. A Prospective Study of Back Pain and Risk of Falls Among Older Community-dwelling Women. J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1177-83. doi: 10.1093/gerona/glv225. Epub 2016 Jan 12.</mixed-citation><mixed-citation xml:lang="en">Marshall LM, Litwack-Harrison S, Cawthon PM, et al. A Prospective Study of Back Pain and Risk of Falls Among Older Community-dwelling Women. J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1177-83. doi: 10.1093/gerona/glv225. Epub 2016 Jan 12.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Patel KV, Phelan EA, Leveille SG, et al. High Prevalence of Falls, Fear of Falling, and Impaired Balance among Older Adults with Pain in the U.S.: Findings from the 2011 National Health and Aging Trends Study. J Am Geriatr Soc. 2014 Oct;62(10):1844-52. doi: 10.1111/jgs.13072. Epub 2014 Oct 3.</mixed-citation><mixed-citation xml:lang="en">Patel KV, Phelan EA, Leveille SG, et al. High Prevalence of Falls, Fear of Falling, and Impaired Balance among Older Adults with Pain in the U.S.: Findings from the 2011 National Health and Aging Trends Study. J Am Geriatr Soc. 2014 Oct;62(10):1844-52. doi: 10.1111/jgs.13072. Epub 2014 Oct 3.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira LS, Sherrington C, Ferreira ML, et al. Self-reported chronic pain is associated with physical performance in older people leaving aged care rehabilitation. Clin Interv Aging. 2014 Feb 5;9:259-65. doi: 10.2147/CIA.S51807.</mixed-citation><mixed-citation xml:lang="en">Pereira LS, Sherrington C, Ferreira ML, et al. Self-reported chronic pain is associated with physical performance in older people leaving aged care rehabilitation. Clin Interv Aging. 2014 Feb 5;9:259-65. doi: 10.2147/CIA.S51807.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kruschinski C, Wiese B, Dierks ML, et al. A geriatric assessment in general practice: prevalence, location, impact and doctor – perceptions of pain. BMC Fam Pract. 2016 Jan 28;17:8. doi: 10.1186/s12875-016-0409-z.</mixed-citation><mixed-citation xml:lang="en">Kruschinski C, Wiese B, Dierks ML, et al. A geriatric assessment in general practice: prevalence, location, impact and doctor – perceptions of pain. BMC Fam Pract. 2016 Jan 28;17:8. doi: 10.1186/s12875-016-0409-z.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Henchoz Y, Bü la C, Guessous I, et al. Chronic symptoms in a representative sample of community-dwelling older people: a crosssectional study in Switzerland. BMJ Open. 2017 Jan 17;7(1):e014485. doi: 10.1136/bmjopen-2016-014485.</mixed-citation><mixed-citation xml:lang="en">Henchoz Y, Bü la C, Guessous I, et al. Chronic symptoms in a representative sample of community-dwelling older people: a crosssectional study in Switzerland. BMJ Open. 2017 Jan 17;7(1):e014485. doi: 10.1136/bmjopen-2016-014485.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gine-Garriga M, Roque-Figuls M, Coll-Planas L, et al. Physical Exercise Interventions for Improving PerformanceBased Measures of Physical Function in Community-Dwelling, Frail Older Adults: A Systematic Review and Meta-Analysis. Arch Phys Med Rehabil. 2014 Apr;95(4): 753-69.e3. doi: 10.1016/j.apmr.2013.11.007. Epub 2013 Nov 27.</mixed-citation><mixed-citation xml:lang="en">Gine-Garriga M, Roque-Figuls M, Coll-Planas L, et al. Physical Exercise Interventions for Improving PerformanceBased Measures of Physical Function in Community-Dwelling, Frail Older Adults: A Systematic Review and Meta-Analysis. Arch Phys Med Rehabil. 2014 Apr;95(4): 753-69.e3. doi: 10.1016/j.apmr.2013.11.007. Epub 2013 Nov 27.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ali S, Garcia JM. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options – a mini-review. Gerontology. 2014;60(4):294-305. doi: 10.1159/000356760. Epub 2014 Apr 8.</mixed-citation><mixed-citation xml:lang="en">Ali S, Garcia JM. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options – a mini-review. Gerontology. 2014;60(4):294-305. doi: 10.1159/000356760. Epub 2014 Apr 8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Turner S, Arthur G, Lyons RA, et al. Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev. 2011 Feb 16;2011(2):CD003600. doi: 10.1002/14651858.CD003600.pub3.</mixed-citation><mixed-citation xml:lang="en">Turner S, Arthur G, Lyons RA, et al. Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev. 2011 Feb 16;2011(2):CD003600. doi: 10.1002/14651858.CD003600.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Chipps J, Jarvis MA, Ramlall S. The effectiveness of e-Interventions on reducing social isolation in older persons: A systematic review of systematic reviews. J Telemed Telecare. 2017 Dec;23(10):817-27. doi: 10.1177/1357633X17733773. Epub 2017 Sep 29.</mixed-citation><mixed-citation xml:lang="en">Chipps J, Jarvis MA, Ramlall S. The effectiveness of e-Interventions on reducing social isolation in older persons: A systematic review of systematic reviews. J Telemed Telecare. 2017 Dec;23(10):817-27. doi: 10.1177/1357633X17733773. Epub 2017 Sep 29.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hegeman J, van den Bemt BJ, Duysens J, van Limbeek J. NSAIDs and the risk of accidental falls in the elderly: a systematic review. Drug Saf. 2009;32(6):489-98. doi: 10.2165/00002018-200932060-00005.</mixed-citation><mixed-citation xml:lang="en">Hegeman J, van den Bemt BJ, Duysens J, van Limbeek J. NSAIDs and the risk of accidental falls in the elderly: a systematic review. Drug Saf. 2009;32(6):489-98. doi: 10.2165/00002018-200932060-00005.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gurina NA, Frolova EV, Degryse JM. A roadmap of aging in Russia: the prevalence of frailty in community-dwelling older adults in the St. Petersburg district — the «Crystal» study. J Am Geriatr Soc. 2011 Jun;59(6):980-8. doi: 10.1111/j.1532-5415.2011.03448.x. Epub 2011 Jun 7.</mixed-citation><mixed-citation xml:lang="en">Gurina NA, Frolova EV, Degryse JM. A roadmap of aging in Russia: the prevalence of frailty in community-dwelling older adults in the St. Petersburg district — the «Crystal» study. J Am Geriatr Soc. 2011 Jun;59(6):980-8. doi: 10.1111/j.1532-5415.2011.03448.x. Epub 2011 Jun 7.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Florence CS, Bergen G, Atherly A, et al. Medical Costs of Fatal and Nonfatal Falls in Older Adults. J Am Geriatr Soc. 2018 Apr; 66(4):693-8. doi: 10.1111/jgs.15304. Epub 2018 Mar 7.</mixed-citation><mixed-citation xml:lang="en">Florence CS, Bergen G, Atherly A, et al. Medical Costs of Fatal and Nonfatal Falls in Older Adults. J Am Geriatr Soc. 2018 Apr; 66(4):693-8. doi: 10.1111/jgs.15304. Epub 2018 Mar 7.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-89. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 3.</mixed-citation><mixed-citation xml:lang="en">Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-89. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 3.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation><mixed-citation xml:lang="en">Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec; 49(3):337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Торшин ИЮ, Лила АМ, Наумов АВ и др. Метаанализ клинических исследований эффективности лечения остеоартита препаратом Хондрогард. Фармакоэкономика. Современная Фармакоэкономика и Фармакоэпидемиология. 2020;13(4): 388-99.</mixed-citation><mixed-citation xml:lang="en">Torshin IYu, Lila AM, Naumov AV, et al. Meta-analysis of clinical studies of the effectiveness of osteoarthritis treatment with Chondrogard. Farmakoekonomika. Sovremennaya Farmakoekonomika i Farmakoepidemiologiya. 2020;13(4):388-99. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rubio-Terres C, Bernad Pineda M, Herrero M, et al. Analysis of the Health and Budgetary Impact of Chondroitin Sulfate Prescription in the Treatment of Knee Osteoarthritis Compared to NSAIDs and COXIBs. Clinicoecon Outcomes Res. 2020 Sep 14;12:505-14. doi: 10.2147/CEOR.S265994. eCollection 2020.</mixed-citation><mixed-citation xml:lang="en">Rubio-Terres C, Bernad Pineda M, Herrero M, et al. Analysis of the Health and Budgetary Impact of Chondroitin Sulfate Prescription in the Treatment of Knee Osteoarthritis Compared to NSAIDs and COXIBs. Clinicoecon Outcomes Res. 2020 Sep 14;12:505-14. doi: 10.2147/CEOR.S265994. eCollection 2020.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Золотовская ИА, Давыдкин ИЛ, Повереннова ИЕ. Терапия неспецифической боли в нижней части спины у пациентов с высоким кардиоваскулярным риском. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(8):18-23. [Zolotovskaya IA, Davydkin IL, Poverennova IE. Therapy of nonspecific lower back pain in patients with high cardiovascular risk. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(8):18-23. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Zolotovskaya IA, Davydkin IL, Poverennova IE. Therapy of nonspecific lower back pain in patients with high cardiovascular risk. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2019;119(8):18-23. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов АВ. Сердечно-сосудистая коморбидность остеоартрита: клиническое значение и стратегии терапии. Российский журнал гериатрической медицины 2021; 2(6):231-6.</mixed-citation><mixed-citation xml:lang="en">Naumov AV. Cardiovascular comorbidity of osteoarthritis: clinical significance and treatment strategies. Rossiiskii zhurnal geriatricheskoi meditsiny 2021;2(6):231-6. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">King DE, Xiang J. Glucosamine/ Chondroitin and Mortality in a US NHANES Cohort. J Am Board Fam Med. Nov-Dec 2020;33(6):842-7. doi: 10.3122/jabfm.2020.06.200110.</mixed-citation><mixed-citation xml:lang="en">King DE, Xiang J. Glucosamine/ Chondroitin and Mortality in a US NHANES Cohort. J Am Board Fam Med. Nov-Dec 2020;33(6):842-7. doi: 10.3122/jabfm.2020.06.200110.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
