mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2022-1-77-83mrj-1256Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSЛечение пациентов с системной красной волчанкой без глюкокортикоидов – миф или реальность?Treatment of patients with systemic lupus erythematosus without glucocorticoids – myth or reality?https://orcid.org/0000-0002-5206-1732СоловьевС. К.SolovievS. K.

123056, Москва, Грузинский переулок, 3А

3A, Gruzinskiy pereulok, Moscow 123056

https://orcid.org/0000-0001-5411-7317МеснянкинаА. А.MesnyankinaA. A.

Анна Александровна Меснянкина

115522, Москва, Каширское шоссе, 34А

Anna Alexandrovna Mesnyankina

34A, Kashirskoe shosse, Moscow 115522

a.a.mesnyankina@gmail.comhttps://orcid.org/0000-0002-4160-7218НикишинаН. Ю.NikishinaN. Yu.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522

https://orcid.org/0000-0002-1663-7810АсееваЕ. А.AseevaE. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А

125993, Москва, ул. Баррикадная, 2/1, стр. 1

34A, Kashirskoe shosse, Moscow 115522

2/1, Barrikadnaya street, building 1, Moscow 125993

АО «Группа компаний МЕДСИ»РоссияJSC Group of companies MEDSIRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»РоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional EducationRussian Federation2022190220221617783Copyright © Соловьев С.К., Меснянкина А.А., Никишина Н.Ю., Асеева Е.А., Лила А.М., 20222022Соловьев С.К., Меснянкина А.А., Никишина Н.Ю., Асеева Е.А., Лила А.М.Soloviev S.K., Mesnyankina A.A., Nikishina N.Y., Aseeva E.A., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1256

Глюкокортикоиды (ГК) в настоящее время остаются одним из важнейших компонентов терапии системной красной волчанки (СКВ). Однако длительное применение ГК неизбежно приводит к развитию необратимых повреждений органов. Доказано преимущество назначения генно-инженерных биологических препаратов, блокирующих ключевые звенья патогенеза СКВ, пациентам с высокой активностью заболевания и зависимостью от применения средних и высоких доз ГК.Представлено три клинических наблюдения, в которых больным с активной СКВ проводилась терапия ритуксимабом и белимумабом без применения пероральных ГК.

Glucocorticoids (GC) currently remain one of the most important components of the treatment of systemic lupus erythematosus (SLE). However, prolonged use of GC inevitably leads to the development of irreversible organ damage. It has been proven that the use of biological diseasemodifying antirheumatic drugs that block key pathogenetic pathways of SLE has an advantage in patients with high disease activity and dependence on the use of medium and high doses of GC.Three clinical cases are presented in which patients with active SLE were treated with rituximab and belimumab without the use of oral GC.

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The authors declare that there are no conflicts of interest present.