References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2022-2-92-98

mrj-1281

Research Article

ОБЗОРЫ

REVIEWS

Анализ механизмов развития нейроревматологических последствий COVID-19 и возможности их фармакологической коррекции

Analysis of the mechanisms of development of neurorheumatological consequences of COVID-19 and the possibility of their pharmacological correction

https://orcid.org/0000-0002-5933-5732

Сарвилина

И. В.

Sarvilina

I. V.

Ирина Владиславовна Сарвилина

Россия, 344002, Ростов-на-Дону, ул. Социалистическая, 74

Irina Vladislavovna Sarvilina

74, Socialisticheskaya street, Rostov-on-Don 344002, Russia

isarvilina@mail.ru

https://orcid.org/0000-0002-6068-3080

Лила

А. М.

Lila

A. M.

Россия, 115522, Москва, Каширское шоссе, 34А

Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1

34A, Kashirskoe shosse, Moscow 115522, Russia

2/1, Barrikadnaya street, building 1, Moscow 125993, Russia

https://orcid.org/0000-0002-7663-710X

Громова

О. А.

Gromova

O. A.

Россия, 119333, Москва, ул. Вавилова, 42

42, Vavilov street, Moscow 119333, Russia

https://orcid.org/0000-0002-2659-7998

Торшин

И. Ю.

Torshin

I. Yu.

Россия, 119333, Москва, ул. Вавилова, 42

42, Vavilov street, Moscow 119333, Russia

https://orcid.org/0000-0003-3726-0730

Шавловская

О. А.

Shavlovskaya

O. A.

Россия, 105062, Москва, Фурманный переулок, 8/2

8/2 Furmanny side street, Moscow 105062, Russia

https://orcid.org/0000-0001-8218-3223

Таскина

Е. А.

Taskina

E. A.

Россия, 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe shosse, Moscow 115522, Russia

ООО «Медицинский центр «Новомедицина»РоссияMedical Center «Novomeditsina»Russian Federation

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; Кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional EducationRussian Federation

Институт фармакоинформатики, Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Control»Russian Federation

АНО ВО «Международный университет восстановительной медицины»РоссияInternational University of Restorative MedicineRussian Federation

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation

2022

06052022

1629298

2022

Сарвилина И.В., Лила А.М., Громова О.А., Торшин И.Ю., Шавловская О.А., Таскина Е.А.

Sarvilina I.V., Lila A.M., Gromova O.A., Torshin I.Y., Shavlovskaya O.A., Taskina E.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/1281

Представлен обзор клинических и экспериментальных исследований, посвященных патогенезу нейроревматологических осложнений (НРО) при COVID-19. Проанализировано влияние системного гипервоспаления, вызванного нарушением врожденного иммунитета, на функционирование нейроваскулярного эндотелия и гематоэнцефалического барьера, активацию сигнальных путей врожденного иммунитета и параинфекционного аутоиммунитета в центральной нервной системе. Показано, что гипервоспаление способствует развитию НРО COVID-19. Рассмотрена потенциальная терапевтическая эффективность лекарственных препаратов, в том числе на основе хондроитина сульфата, которые могут использоваться для профилактики и лечения НРО COVID-19.

We present the review of clinical and experimental studies on the pathogenesis of neurorheumatological complications (NRC) in COVID-19. The influence of systemic hyperinflammation caused by impaired innate immunity on the functioning of the neurovascular endothelium and the bloodbrain barrier, activation of signaling pathways of innate immunity and parainfectious autoimmunity in the central nervous system were analyzed.

Hyperinflammation has been shown to contribute to the development of NRC in COVID-19. The potential therapeutic efficacy of drugs, including those based on chondroitin sulfate, which can be used for the prevention and treatment of NRC in COVID-19, is considered.

COVID-19нейроревматологические осложнениятерапия

COVID-19neurorheumatological complicationstherapy

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https://www.sciencedirect.com/journal/journal-of-the-neurological-sciences/specialissue/109QBJSVZ2T

The authors declare that there are no conflicts of interest present.