mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2022-4-80-87mrj-1327Research ArticleОБЗОРЫREVIEWSТерапия остеоартрита коленных суставов с точки зрения доказательной медицины: ожидаемые краткосрочные, среднесрочные и долгосрочные результаты применения рецептурного кристаллического глюкозамина сульфатаEvidence-based therapy for knee osteoarthritis: expected short-, medium-, and long-term outcomes of prescription crystalline glucosamine sulfate administrationhttps://orcid.org/0000-0002-6064-7880ДенисовЛ. Н.DenisovL. N.

 Лев Николаевич Денисов

Россия, 115522, Москва, Каширское шоссе, 34А 

 Lev Nikolaevich Denisov 

34A, Kashirskoe shosse, Moscow 115522, Russia 

Lev-denisov1941@mail.ruhttps://orcid.org/0000-0001-7017-0898АлексееваЛ. И.AlekseevaL. I.

 Россия, 115522, Москва, Каширское шоссе, 34А 

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

34A, Kashirskoe shosse, Moscow 115522, Russia 

 2/1, Barrikadnaya street, building 1, Moscow 125993, Russia 

https://orcid.org/0000-0002-4579-2836ЗоткинЕ. Г.ZotkinE. G.

 Россия, 115522, Москва, Каширское шоссе, 34А 

34A, Kashirskoe shosse, Moscow 115522, Russia 

https://orcid.org/0000-0002-2985-8831ДыдыкинаИ. С.DydykinaI. S.

 Россия, 115522, Москва, Каширское шоссе, 34А 

34A, Kashirskoe shosse, Moscow 115522, Russia 

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

 Россия, 115522, Москва, Каширское шоссе, 34А 

 Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

34A, Kashirskoe shosse, Moscow 115522, Russia 

 2/1, Barrikadnaya street, building 1, Moscow 125993, Russia 

https://orcid.org/0000-0002-2726-8758РодионоваС. С.RodionovaS. S.

 Россия, 127299, Москва, ул. Приорова, 10 

 10, Priorova street, Moscow 127299, Russia 

https://orcid.org/0000-0002-2466-7120КочишА. Ю.KochishA. Yu.

 Россия, 195427, Санкт-Петербург, ул. академика Байкова, 8 

 8, Academician Baikov street, St. Petersburg 195427, Russia 

https://orcid.org/0000-0002-4579-2836ТрофимовЕ. А.TrofimovE. A.

 Россия, 191015, Санкт-Петербург, ул. Кирочная, 41 

 41, Kirochnaya st., St. Petersburg 191015, Russia 

https://orcid.org/0000-0003-2965-1424ЯкуповЭ. З.YakupovE. Z.

 Россия, 420012, Казань, ул. Бутлерова, 49 

 49, Butlerova street, Kazan 420012, Russia 

https://orcid.org/0000-0002-8590-4839ЯкуповаС. П.YakupovaS. P.

 Россия, 420012, Казань, ул. Бутлерова, 49 

 49, Butlerova street, Kazan 420012, Russia 

ЕлисееваЛ. Н.EliseevaL. N.

 Россия, 350063, Краснодар, ул. им. Митрофана Седина, 4 

 https://orcid.org/0000-0002-5275-3266 

 4, Mitrofan Sedin street, Krasnodar 350063, Russia 

 https://orcid.org/0000-0002-5275-3266 

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology, Russian Medical Academy of Continuing Professional EducationRussian FederationНаучно-клинический центр остеопороза ФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Н.Н. Приорова»РоссияNational Medical Research Center for Traumatology and Orthopedics named after N.N. PriorovRussian FederationФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Р.Р. Вредена» Минздрава РоссииРоссияNational Medical Research Center of Traumatology and Orthopedics named after R.R. VredenRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University named after I.I. Mechnikov, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Кубанский государственный медицинский университет», Минздрава РоссииРоссияKuban State Medical University, Ministry of Health of RussiaRussian Federation2022210820221648087Copyright © Денисов Л.Н., Алексеева Л.И., Зоткин Е.Г., Дыдыкина И.С., Лила А.М., Родионова С.С., Кочиш А.Ю., Трофимов Е.А., Якупов Э.З., Якупова С.П., Елисеева Л.Н., 20222022Денисов Л.Н., Алексеева Л.И., Зоткин Е.Г., Дыдыкина И.С., Лила А.М., Родионова С.С., Кочиш А.Ю., Трофимов Е.А., Якупов Э.З., Якупова С.П., Елисеева Л.Н.Denisov L.N., Alekseeva L.I., Zotkin E.G., Dydykina I.S., Lila A.M., Rodionova S.S., Kochish A.Y., Trofimov E.A., Yakupov E.Z., Yakupova S.P., Eliseeva L.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1327

Потребность в эффективных препаратах для терапии остеоартрита (ОА) коленных суставов (КС) постоянно растает. В современных руководствах рекомендуется применять при этом заболевании симптоматические средства замедленного действия (SYSADOA), такие как глюкозамин (ГКА). Среди различных лекарственных средств, содержащих ГКА, высокая биодоступность и клиническая эффективность доказаны только для рецептурного кристаллического ГКА сульфата (рГКАС). В нескольких метаанализах и сетевых метаанализах было показано, что рГКАС в дозе 1500 мг 1 раз в сутки превосходит по эффективности другие продукты на основе ГКА (такие как ГКА гидрохлорид с натрия сульфатом или без него) и комбинации ГКА с хондроитина сульфатом (ХС) с точки зрения снижения интенсивности боли и улучшения функционального состояния. В этих исследованиях был подтвержден благоприятный профиль безопасности рГКАС, который по частоте развития нежелательных явлений был сопоставим с плацебо. Фармакоэкономические исследования также продемонстрировали большую экономическую эффективность рГКАС по сравнению с другими лекарственными средствами ГКА.Группа российских экспертов на совещании консультативного комитета рассмотрела свидетельства в пользу применения рГКАС и доказательства его эффективности при лечении ОА КС в сравнении с другими продуктами, в состав которых входит ГКА, и фиксированной комбинации ГКА с ХС. С учетом полученных результатов использование рГКАС в дозе 1500 мг 1 раз в сутки рекомендовано в качестве рационального выбора для лечения ОА КС.

The need for effective drugs for the treatment of knee osteoarthritis (OA) is constantly growing. Current guidelines recommend the use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) such as glucosamine (GCA) in this disease. Among various drugs containing GCA, high bioavailability and clinical efficacy have been shown only for prescription crystalline GCA sulfate (pGCAS) administration. Several meta-analyses and network meta-analyses have shown that efficacy of pGCAS 1500 mg once daily is superior to other GCA-based products (such as GCA hydrochloride with or without sodium sulfate) and the combination of GCA with chondroitin sulfate (CS) in terms of reducing the intensity of pain and improving the functional state. These studies confirmed the favorable safety profile of pGCAS, which was comparable to placebo in the incidence of adverse events. Pharmacoeconomic studies have also demonstrated greater cost-effectiveness of pGCAS compared to other GCA drugs.A group of Russian experts at a meeting of the advisory committee reviewed the evidence in favor of the use of pGCAS and evidence of its effectiveness in the treatment of knee OA in comparison with other products that include GCA, and the fixed combination of GCA with CS. Taking into account the results obtained, the use of pGCAS at a dose of 1500 mg once a day is recommended as a rational choice for the treatment of knee OA.

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The authors declare that there are no conflicts of interest present.