mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2022-4-111-116mrj-1331Research ArticleОБЗОРЫREVIEWSО перспективах использования неденатурированного коллагена II типа в терапии остеоартрита и других заболеваний суставовOn the prospects for the use of undenatured type II collagen in the treatment of osteoarthritis and other joint diseaseshttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

 Ольга Алексеевна Громова; unesco.gromova@gmail.com 

 Россия, 119333, Москва, ул. Вавилова, 44, корп. 2 

 Olga Alekseevna Gromova 

 44, Vavilov street, building 2, Moscow 119333, Russia 

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

 Россия, 119333, Москва, ул. Вавилова, 44, корп. 2 

 44, Vavilov street, building 2, Moscow 119333, Russia 

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

 Россия, 115522, Москва, Каширское шоссе, 34А

Россия, 125993, Москва, ул. Баррикадная, 2/1, стр. 1 

34A, Kashirskoe Shosse, Moscow 115522, Russia

2/1, Barrikadnaya street, building 1, Moscow 125993, Russia 

https://orcid.org/0000-0003-3726-0730ШавловскаяО. А.ShavlovskayaO. A.

 Россия, 105062, Москва, Фурманный переулок, 8, корп. 2 

 8, Furmanny lane, building 2, Moscow 105062, Russia 

Институт фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наукРоссияInstitute of Pharmacoinformatics of the Federal Research Center "Computer Science and Management", Russian Academy of SciencesRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; Кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuing Professional EducationRussian FederationАНО ВО «Международный университет восстановительной медицины»РоссияInternational University of Restorative MedicineRussian Federation202223082022164111116Copyright © Громова О.А., Торшин И.Ю., Лила А.М., Шавловская О.А., 20222022Громова О.А., Торшин И.Ю., Лила А.М., Шавловская О.А.Gromova O.A., Torshin I.Y., Lila A.M., Shavlovskaya O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1331

Стандартизированные экстракты неденатурированного коллагена II типа (НК-II) используются в качестве альтернативных подходов к лечению остеоартрита (ОА). Действие экстрактов НК-II связано с модуляцией механизмов врожденного и приобретенного иммунитета, снижением активности провоспалительных цитокинов и простагландинов. Эпитопы нативного коллагена в структуре НК-II способствуют уменьшению активности аутоиммунных реакций, стимулирующих деградацию хряща. Взаимодействуя с дискоидиновыми рецепторами, НК-II ускоряет реконструкцию соединительной ткани хряща и тормозит провоспалительные эффекты эндогенных коллагенов. Экспериментальные и клинические исследования подтверждают эффективность использования стандартизированных субстанций НК-II для ускорения регенерации хряща и уменьшения боли при ОА и субклинической дисфункции суставов.

Standardized extracts of undenatured type II collagen (UC-II) are used as alternative approaches to the treatment of osteoarthritis (OA). The effect of UC-II extracts is associated with the modulation of the mechanisms of innate and acquired immunity, a decrease in the activity of proinflammatory cytokines and prostaglandins. Epitopes of native collagen in the structure of UC-II contribute to a decrease in the activity of autoimmune reactions that stimulate cartilage degradation. Interacting with discoidin receptors, UC-II accelerates the reconstruction of cartilage connective tissue and inhibits the pro-inflammatory effects of endogenous collagens. Experimental and clinical studies confirm the effectiveness of the use of standardized substances UC-II for acceleration of cartilage regeneration and reduce pain in OA and subclinical joint dysfunction.

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The authors declare that there are no conflicts of interest present.