mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2022-4-117-121mrj-1332Research ArticleОБЗОРЫREVIEWSЛорноксикам в терапии острой и хронической скелетно-мышечной болиLornoxicam in the treatment of acute and chronic musculoskeletal painhttps://orcid.org/0000-0001-5103-5447ПолищукЕ. Ю.PolishchukE. Yu.

Елена Юрьевна Полищук

Россия, 115522, Москва, Каширское шоссе, 34А 

 Elena Yurievna Polishchuk 

 34A, Kashirskoe shosse, Moscow 115522, Russia 

dr.pogozheva@gmail.comhttps://orcid.org/0000-0002-1391-0711КаратеевА. Е.KarateevA. E.

 Россия, 115522, Москва, Каширское шоссе, 34А 

 34A, Kashirskoe shosse, Moscow 115522, Russia 

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202223082022164117121Copyright © Полищук Е.Ю., Каратеев А.Е., 20222022Полищук Е.Ю., Каратеев А.Е.Polishchuk E.Y., Karateev A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1332

Нестероидные противовоспалительные препараты (НПВП) – одни из наиболее часто применяемых в мире лекарственных средств, которые назначаются по широкому кругу показаний, в том числе при остеоартрите, ревматоидном артрите, других заболеваниях опорно-двигательного аппарата и мягких тканей, а также для облегчения послеоперационной боли. Хорошо известно, что прием НПВП связан с риском развития осложнений со стороны желудочно-кишечного тракта (ЖКТ), сердечно-сосудистой системы (ССС) и почек. Лорноксикам относится к НПВП класса оксикамов и является сбалансированным ингибитором обеих изоформ циклооксигеназы (ЦОГ) – ЦОГ1 и ЦОГ2 – и отличается от других оксикамов быстрым началом действия, высокой скоростью элиминации. Препарат характеризуется выраженным анальгетическим эффектом и благоприятным профилем безопасности как в отношении ЖКТ, так и ССС, не требует коррекции дозы у пациентов старше 65 лет.

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used type of drugs in the world and are prescribed for a wide range of indications, including osteoarthritis, rheumatoid arthritis, other diseases of the musculoskeletal system and soft tissues, as well as for the relief of postoperative pain. It is well known that the use of NSAIDs is associated with the risk of gastrointestinal (GIT), cardiovascular (CVS) and kidneys complications. Lornoxicam belongs to the NSAIDs of the oxicam class and is a balanced inhibitor of both cyclooxygenase (COX) isoforms – COX1 and COX2 – and differs from other oxicams in its rapid onset of action, high elimination rate. The drug is characterized by a pronounced analgesic effect and a favorable safety profile both in relation to the gastrointestinal tract and cardiovascular system, does not require dose adjustment in patients over 65 years of age.

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The authors declare that there are no conflicts of interest present.