mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2022-5-108-113mrj-1355Research ArticleОБЗОРЫREVIEWSМолекулярные механизмы действия неденатурированного коллагена II типа: экспериментальные и клинические данныеMolecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidencehttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Ольга Алексеевна Громова

119333, Москва, ул. Вавилова, 44, корп. 2

Olga A. Gromova

44, Vavilov Street, Building 2, Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

119333, Москва, ул. Вавилова, 44, корп. 2

44, Vavilov Street, Building 2, Moscow 119333

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А,

125993, Москва, ул. Баррикадная, 2/1, стр. 1

34A, Kashirskoe Shosse, Moscow 115522,

2/1, Barrikadnaya Street, Building 1, Moscow 125993

 

Институт фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наукРоссияInstitute of Pharmacoinformatics of the Federal Research Center "Computer Science and Management", Russian Academy of SciencesRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; Кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuing Professional EducationRussian Federation202219102022165108113Copyright © Громова О.А., Торшин И.Ю., Лила А.М., 20222022Громова О.А., Торшин И.Ю., Лила А.М.Gromova O.A., Torshin I.Y., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1355

В лечении заболеваний суставов, в том числе остеоартрита (ОА), перспективным является применение стандартизированных экстрактов неденатурированного коллагена II типа (НК-II). Известно, что НК-II участвует в регулировке врожденного и приобретенного иммунитета (уменьшение аутоиммунных реакций, стимулирующих деградацию хряща) и в снижении активности хронического воспаления (модуляция уровней цитокинов и простагландинов). Воздействие НК-II на дискоидиновые рецепторы хондроцитов способствует предотвращению структурных нарушений соединительной ткани хряща. Экспериментальные и клинические исследования показали, что под влиянием стандартизированного НК-II происходят увеличение доли регуляторных CD4+ Т-клеток, снижение уровней провоспалительных цитокинов, таких как интерлейкин (ИЛ) 1β, ИЛ6, фактор некроза опухоли α, СРБ, простагландинов в крови, а также матриксной металлопротеиназы 3 и экспрессии NF-κB в хряще. Применение НК-II при ОА приводит к значительному уменьшению боли, увеличению объема движений в суставах, улучшению функции суставов по WOMAC и качества жизни.

In the treatment of joint diseases, including osteoarthritis (OA), the use of standardized extracts of undenatured type II collagen (UDC-II) is promising. It is known that UDC-II is involved in the regulation of innate and adaptive immunity (reduction of autoimmune reactions that stimulate cartilage degradation) and in the reduction of chronic inflammation activity (modulation of cytokines and prostaglandins). The effect of UDC-II on discoidin receptors of chondrocytes helps to prevent structural disorders of the cartilage connective tissue. Experimental and clinical studies have shown that under the influence of standardized UDC-II, there is an increase in the proportion of regulatory CD4+ T cells, a decrease in the levels of pro-inflammatory cytokines, such as interleukin (IL) 1β, IL6, tumor necrosis factor α, CRP, prostaglandins in the blood, as well as matrix metalloproteinase 3 and NF-κB expression in cartilage. The use of UDC-II in OA leads to a significant reduction in pain, an increase in the range of joint motion, an improvement in joint function according to WOMAC and quality of life.

 

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The authors declare that there are no conflicts of interest present.