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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2022-6-98-105</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1378</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Остеоартрит суставов кистей: распространенность, факторы риска, фенотипы, диагностика, лечение</article-title><trans-title-group xml:lang="en"><trans-title>Osteoarthritis of hand joints: prevalence, risk factors, phenotypes, diagnosis, treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7017-0898</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>L. I</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеева Людмила Ивановна - кафедра ревматологии РМАНПО МЗ РФ.</p><p>115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Lyudmila I. Alekseeva - Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia.</p><p>34A, Kashirskoe Shosse, Moscow 115522; 22/1, Barrikadnaya Street, Build. 1, Moscow 125993</p></bio><email xlink:type="simple">dr.alekseeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2048-5183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарапова</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharapova</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра ревматологии РМАНПО МЗ РФ.</p><p>115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia.</p><p>34A, Kashirskoe Shosse, Moscow 115522; 22/1, Barrikadnaya Street, Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт ревматологии им. В.А. Насоновой; Российская медицинская академия непрерывного профессионального образования Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology, Moscow; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт ревматологии им. В.А. Насоновой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2022</year></pub-date><volume>16</volume><issue>6</issue><fpage>98</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеева Л.И., Шарапова Е.П., Лила А.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Алексеева Л.И., Шарапова Е.П., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Alekseeva L.I., Sharapova E.P., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1378">https://mrj.ima-press.net/mrj/article/view/1378</self-uri><abstract><p>Остеоартрит — самое распространенное ревматическое заболевание, сопровождающееся постоянной болью и нарушением функции суставов, прогрессирование которого приводит к ухудшению качества жизни и нередко к инвалидизации пациентов. В статье представлены распространенность, предикторы развития и прогрессирования остеоартрита суставов кистей (ОАК). Приведены клиническая классификация ОАК, клиническая картина заболевания в зависимости от локализации процесса, топические особенности вовлечения суставов кистей при разных вариантах ОАК. Описаны клинические и лабораторно-инструментальные методы диагностики заболевания, классификационные и диагностические критерии, большое внимание уделено современным принципам терапии ОАК в соответствии с российскими клиническими рекомендациями, а также рекомендациями EULAR и ACR.</p></abstract><trans-abstract xml:lang="en"><p>Osteoarthritis is the most common rheumatic disease, accompanied by constant pain and dysfunction of the joints, the progression of which leads to a deterioration in the quality of life and often to disability of patients. The article presents the prevalence, predictors of development and progression of osteoarthritis of the hand joints (OHJ). Clinical classification of OHJ, clinical picture depending on the localization of the process, topical features of involvement of the hand joints in different types of OHJ are given. Clinical, laboratory and instrumental methods for diagnosing of the disease, classification and diagnostic criteria are described, much attention is paid to modern principles of OHJ therapy in accordance with Russian clinical guidelines, as well as EULAR and ACR recommendations.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит суставов кистей</kwd><kwd>фенотипы</kwd><kwd>эпидемиология</kwd><kwd>классификация</kwd><kwd>факторы риска</kwd><kwd>клинические проявления</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis of the hand joints</kwd><kwd>phenotypes</kwd><kwd>epidemiology</kwd><kwd>classification</kwd><kwd>risk factors</kwd><kwd>clinical manifestations</kwd><kwd>diagnostics</kwd><kwd>treatment</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках Государственного задания по теме № N1021051403074-2.</funding-statement><funding-statement xml:lang="en">The investigation has been conducted within scientific topic №N1021051403074-2</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лила АМ, Лила ВА. Социальная значимость и экономические последствия ревматических заболеваний. Гигиена и санитария. 2017;(4):387-92.</mixed-citation><mixed-citation xml:lang="en">Lila AM, Lila VA. Social significance and economic consequences of rheumatic diseases. Gigiena i sanitariya. 2017;(4):387-92. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sangha O. Epidemiology of rheumatic disease. Rheumatology (Oxford). 2000 Dec;39 Suppl 2:3-12. doi: 10.1093/rheumatology/39.suppl_2.3.</mixed-citation><mixed-citation xml:lang="en">Sangha O. Epidemiology of rheumatic disease. Rheumatology (Oxford). 2000 Dec;39 Suppl 2:3-12. doi: 10.1093/rheumatology/39.suppl_2.3.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009 Jan;68(1):8-17. doi: 10.1136/ard.2007.084772. Epub 2008 Feb 4.</mixed-citation><mixed-citation xml:lang="en">Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009 Jan;68(1):8-17. doi: 10.1136/ard.2007.084772. Epub 2008 Feb 4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ЛИ, Таскина ЕА, Кашеварова НГ. Остеоартрит: эпидемиология, классификация, факторы риска и прогрессирования, клиника, диагностика, лечение. Современная ревматология. 2019;13(2):9-21. doi: 10.14412/1996-7012-2019-2-9-21</mixed-citation><mixed-citation xml:lang="en">Alekseeva LI, Taskina EA, Kashevarova NG. Osteoarthritis: epidemiology, classification, risk factors, and progression, clinical presentation, diagnosis, and treatment. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2019;13(2):9-21. (In Russ.). doi: 10.14412/1996-7012-2019-2-9-21</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppenburg M, Kwok WY. Hand osteoarthritis — a heterogeneous disorder. Nat Rev Rheumatol. 2011 Nov 22;8(1):22-31. doi: 10.1038/nrrheum.2011.170.</mixed-citation><mixed-citation xml:lang="en">Kloppenburg M, Kwok WY. Hand osteoarthritis — a heterogeneous disorder. Nat Rev Rheumatol. 2011 Nov 22;8(1):22-31. doi: 10.1038/nrrheum.2011.170.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Niu J, Kelly-Hayes M, et al. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among elderly: the Framingham Study. Am J Epidemiol. 2002 Dec 1;156(11):1021-7. doi: 10.1093/ aje/kwf141.</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Niu J, Kelly-Hayes M, et al. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among elderly: the Framingham Study. Am J Epidemiol. 2002 Dec 1;156(11):1021-7. doi: 10.1093/ aje/kwf141.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wright GD, Regan M, Deighton CM, et al. Evidence for genetic anticipation in nodal osteoarthritis. Ann Rheum Dis. 1998 Sep;57(9): 524-6. doi: 10.1136/ard.57.9.524.</mixed-citation><mixed-citation xml:lang="en">Wright GD, Regan M, Deighton CM, et al. Evidence for genetic anticipation in nodal osteoarthritis. Ann Rheum Dis. 1998 Sep;57(9): 524-6. doi: 10.1136/ard.57.9.524.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Штерн К. Основы генетики человека. Москва: Медицина; 1965. C.196.</mixed-citation><mixed-citation xml:lang="en">Shtern K. Osnovy genetiki cheloveka [Fundamentals of human genetics]. Moscow: Meditsina; 1965. P.196.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gazeley DJ, Yeturi S, Patel PJ, Rosenthal AK. Erosive osteoarthritis: A systematic analysis of definitions used in the literature. Semin Arthritis Rheum. 2017 Feb;46(4):395-403. doi: 10.1016/j.semarthrit.2016.08.013. Epub 2016 Aug 24.</mixed-citation><mixed-citation xml:lang="en">Gazeley DJ, Yeturi S, Patel PJ, Rosenthal AK. Erosive osteoarthritis: A systematic analysis of definitions used in the literature. Semin Arthritis Rheum. 2017 Feb;46(4):395-403. doi: 10.1016/j.semarthrit.2016.08.013. Epub 2016 Aug 24.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Poletto E, Tinazzi I, Marchetta A, et al. Hand Erosive Osteoarthritis and Distal Inter-phalangeal Involvement in Psoriatic Arthritis: The Place of Conservative Therapy. J Clin Med. 2021 Jun 15;10(12):2630. doi: 10.3390/jcm10122630.</mixed-citation><mixed-citation xml:lang="en">Poletto E, Tinazzi I, Marchetta A, et al. Hand Erosive Osteoarthritis and Distal Inter-phalangeal Involvement in Psoriatic Arthritis: The Place of Conservative Therapy. J Clin Med. 2021 Jun 15;10(12):2630. doi: 10.3390/jcm10122630.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов АВ. Атлас рентгенологической диагностики первичного остеоартроза. Москва: ИМА-ПРЕСС; 2010.</mixed-citation><mixed-citation xml:lang="en">Smirnov AV. Atlas rentgenologicheskoi diagnostiki pervichnogo osteoartroza [Atlas of radiological diagnostics of primary osteoarthritis]. Moscow: IMA-PRESS; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Кудинский ДМ, Смирнов АВ, Алексеева ЛИ. Сравнение рентгенографии и магнитно-резонансной томографии при диагностике остеоартрита суставов кистей. Научно-практическая ревматология. 2019;57(1):91-9.</mixed-citation><mixed-citation xml:lang="en">Kudinsky DM, Smirnov AV, Alekseeva LI. Comparison of X-ray and magnetic resonance imaging in the diagnosis of osteoarthritis of the joints of the hands. Nauchno-prakticheskaya revmatologiya. 2019;57(1):91-9 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Altman R, Alarcn G, Appelrouth D, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990 Nov;33(11):1601-10. doi: 10.1002/art.1780331101.</mixed-citation><mixed-citation xml:lang="en">Altman R, Alarcn G, Appelrouth D, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990 Nov;33(11):1601-10. doi: 10.1002/art.1780331101.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang W, Doherty M, Leeb BF, et al. Review. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2007 Mar;66(3):377-88. doi: 10.1136/ard.2006.062091.</mixed-citation><mixed-citation xml:lang="en">Zhang W, Doherty M, Leeb BF, et al. Review. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2007 Mar;66(3):377-88. doi: 10.1136/ard.2006.062091.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppenburg M, Kroon FP, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019 Jan;78(1):16-24. doi: 10.1136/annrheumdis-2018-213826. Epub 2018 Aug 28.</mixed-citation><mixed-citation xml:lang="en">Kloppenburg M, Kroon FP, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019 Jan;78(1):16-24. doi: 10.1136/annrheumdis-2018-213826. Epub 2018 Aug 28.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-89. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 3.</mixed-citation><mixed-citation xml:lang="en">Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 Nov;27(11):1578-89. doi: 10.1016/j.joca.2019.06.011. Epub 2019 Jul 3.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American college of rheumatology/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62. doi: 10.1002/acr.24131. Epub 2020 Jan 6.</mixed-citation><mixed-citation xml:lang="en">Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American college of rheumatology/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62. doi: 10.1002/acr.24131. Epub 2020 Jan 6.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fuggle N, Bere N, Bruycre O, et al. Management of hand osteoarthritis: from an US evidence based medicine guideline to a European patient centric approach. Aging Clin Exp Res. 2022 Sep;34(9):1985-95. doi: 10.1007/s40520-022-02176-y. Epub 2022 Jul 21.</mixed-citation><mixed-citation xml:lang="en">Fuggle N, Bere N, Bruycre O, et al. Management of hand osteoarthritis: from an US evidence based medicine guideline to a European patient centric approach. Aging Clin Exp Res. 2022 Sep;34(9):1985-95. doi: 10.1007/s40520-022-02176-y. Epub 2022 Jul 21.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyd'c O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3): 337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation><mixed-citation xml:lang="en">Bruyd'c O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3): 337-50. doi: 10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/ disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage. 1998 May;6 Suppl A:37-8. doi: 10.1016/s1063-4584(98)80010-1.</mixed-citation><mixed-citation xml:lang="en">Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/ disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage. 1998 May;6 Suppl A:37-8. doi: 10.1016/s1063-4584(98)80010-1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gabay C, Medinger-Sadowski C, Gascon D, et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum. 2011 Nov;63(11):3383-91. doi: 10.1002/art.30574</mixed-citation><mixed-citation xml:lang="en">Gabay C, Medinger-Sadowski C, Gascon D, et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum. 2011 Nov;63(11):3383-91. doi: 10.1002/art.30574</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Лила АМ, Алексеева ЛИ, Таскина ЕА. Современные подходы к терапии остеоартрита с учетом обновленных международных рекомендаций. Русский медицинский журнал. Медицинское обозрение. 2019;3(11-2):48-52.</mixed-citation><mixed-citation xml:lang="en">Lila AM, Alekseeva LI, Taskina EA. Modern approaches to the treatment of osteoarthritis based on the updated international recommendations. Russkii meditsinskii zhurnal. Meditsinskoe obozrenie. 2019;3(11-2):48-52. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese N, Demurtas J, Smith L, et al; European Geriatric Medicine Society Special Interest Groups in Systematic Reviews and Meta-Analyses and Arthritis. Glucosamine sulphate: an umbrella review of health outcomes. Ther Adv Musculoskelet Dis.2020 Dec 26;12:1759720X20975927. doi: 10.1177/1759720X20975927. eCollection 2020.</mixed-citation><mixed-citation xml:lang="en">Veronese N, Demurtas J, Smith L, et al; European Geriatric Medicine Society Special Interest Groups in Systematic Reviews and Meta-Analyses and Arthritis. Glucosamine sulphate: an umbrella review of health outcomes. Ther Adv Musculoskelet Dis.2020 Dec 26;12:1759720X20975927. doi: 10.1177/1759720X20975927. eCollection 2020.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tenti S, Giordano N, Mondanelli N, et al. A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment alone. Aging Clin Exp Res. 2020 Jun;32(6):1161-72. doi: 10.1007/s40520-019-01305-4. Epub 2019 Aug 19.</mixed-citation><mixed-citation xml:lang="en">Tenti S, Giordano N, Mondanelli N, et al. A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment alone. Aging Clin Exp Res. 2020 Jun;32(6):1161-72. doi: 10.1007/s40520-019-01305-4. Epub 2019 Aug 19.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppenburg M, Peterfy C, Haugen IK, et al. Phase IIa, placebo-controlled, randomised study of lutikizumab, an antiinterleukin-1 and anti-interleukin-1 dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis. Ann Rheum Dis. 2019 Mar;78(3):413-20. doi: 10.1136/annrheum-dis-2018-213336. Epub 2018 Dec 14.</mixed-citation><mixed-citation xml:lang="en">Kloppenburg M, Peterfy C, Haugen IK, et al. Phase IIa, placebo-controlled, randomised study of lutikizumab, an antiinterleukin-1 and anti-interleukin-1 dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis. Ann Rheum Dis. 2019 Mar;78(3):413-20. doi: 10.1136/annrheum-dis-2018-213336. Epub 2018 Dec 14.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kloppenburg M, Ramonda R, Bobacz K, et al. Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2018 Dec;77(12):1757-64. doi: 10.1136/annrheumdis-2018-213202. Epub 2018 Oct 3.</mixed-citation><mixed-citation xml:lang="en">Kloppenburg M, Ramonda R, Bobacz K, et al. Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2018 Dec;77(12):1757-64. doi: 10.1136/annrheumdis-2018-213202. Epub 2018 Oct 3.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Schett G, Bainbridge C, Berkowitz M, et al. Anti-granulocyte-macrophage colonystimulating factor antibody otilimab in patients with hand osteoarthritis: a phase 2a randomised trial. Lancet Rheumatol. 2020;2: e623-e632.</mixed-citation><mixed-citation xml:lang="en">Schett G, Bainbridge C, Berkowitz M, et al. Anti-granulocyte-macrophage colonystimulating factor antibody otilimab in patients with hand osteoarthritis: a phase 2a randomised trial. Lancet Rheumatol. 2020;2: e623-e632.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Aitken D, Laslett LL, Pan F, et al. A randomised doubleblind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand osteoarthritis - the HUMOR trial. Osteoarthritis Cartilage. 2018 Jul;26(7):880-7. doi: 10.1016/j.joca.2018.02.899. Epub 2018 Mar 2.</mixed-citation><mixed-citation xml:lang="en">Aitken D, Laslett LL, Pan F, et al. A randomised doubleblind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand osteoarthritis - the HUMOR trial. Osteoarthritis Cartilage. 2018 Jul;26(7):880-7. doi: 10.1016/j.joca.2018.02.899. Epub 2018 Mar 2.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Chevalier X, Ravaud P, Maheu E, et al. Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial. Ann Rheum Dis. 2015 Sep;74(9):1697-705. doi: 10.1136/annrheum-dis-2014-205348. Epub 2014 May 9.</mixed-citation><mixed-citation xml:lang="en">Chevalier X, Ravaud P, Maheu E, et al. Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial. Ann Rheum Dis. 2015 Sep;74(9):1697-705. doi: 10.1136/annrheum-dis-2014-205348. Epub 2014 May 9.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Richette P, Latourte A, Sellam J, et al. Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial. Ann Rheum Dis. 2021 Mar;80(3):349-55. doi: 10.1136/annrheumdis-2020-218547. Epub 2020 Oct 14.</mixed-citation><mixed-citation xml:lang="en">Richette P, Latourte A, Sellam J, et al. Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial. Ann Rheum Dis. 2021 Mar;80(3):349-55. doi: 10.1136/annrheumdis-2020-218547. Epub 2020 Oct 14.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kedor C, Detert J, Rau R, et al. Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands: results of the OA-TREAT study-a randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial. RMD Open. 2021 Jul;7(2):e001660. doi: 10.1136/rmdopen-2021-001660.</mixed-citation><mixed-citation xml:lang="en">Kedor C, Detert J, Rau R, et al. Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands: results of the OA-TREAT study-a randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial. RMD Open. 2021 Jul;7(2):e001660. doi: 10.1136/rmdopen-2021-001660.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kingsbury SR, Tharmanathan P, Keding A, et al. Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis: a randomized trial. Ann Intern Med. 2018 Mar 20;168(6):385-95. doi: 10.7326/M17-1430. Epub 2018 Feb 20.</mixed-citation><mixed-citation xml:lang="en">Kingsbury SR, Tharmanathan P, Keding A, et al. Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis: a randomized trial. Ann Intern Med. 2018 Mar 20;168(6):385-95. doi: 10.7326/M17-1430. Epub 2018 Feb 20.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lee W, Ruijgrok L, Boxma-de Klerk B, et al. Efficacy of hydroxychloroquine in hand osteoarthritis: a randomized, double-blind placebo-controlled trial. Arthritis Care Res (Hoboken). 2018 Sep;70(9):1320-5. doi: 10.1002/acr.23471. Epub 2018 Aug 12.</mixed-citation><mixed-citation xml:lang="en">Lee W, Ruijgrok L, Boxma-de Klerk B, et al. Efficacy of hydroxychloroquine in hand osteoarthritis: a randomized, double-blind placebo-controlled trial. Arthritis Care Res (Hoboken). 2018 Sep;70(9):1320-5. doi: 10.1002/acr.23471. Epub 2018 Aug 12.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Davis CR, Ruediger CD, Dyer KA, et al. Colchicine is noteffective for reducing osteo-arthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH). Osteoarthritis Cartilage. 2021 Feb;29(2):208-14. doi: 10.1016/j.joca.2020.11.002. Epub 2020 Nov 21.</mixed-citation><mixed-citation xml:lang="en">Davis CR, Ruediger CD, Dyer KA, et al. Colchicine is noteffective for reducing osteo-arthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH). Osteoarthritis Cartilage. 2021 Feb;29(2):208-14. doi: 10.1016/j.joca.2020.11.002. Epub 2020 Nov 21.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrero S, Wittoek R, Allado E, et al. Methotrexate treatment in hand osteoarthritis refractory to usual treatments: a randomised, double-blind, placebo-controlled trial. Semin Arthritis Rheum. 2021 Aug;51(4):831-8. doi: 10.1016/j.semarthrit.2021.04.016. Epub 2021 May 6.</mixed-citation><mixed-citation xml:lang="en">Ferrero S, Wittoek R, Allado E, et al. Methotrexate treatment in hand osteoarthritis refractory to usual treatments: a randomised, double-blind, placebo-controlled trial. Semin Arthritis Rheum. 2021 Aug;51(4):831-8. doi: 10.1016/j.semarthrit.2021.04.016. Epub 2021 May 6.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
