mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2023-1-93-100mrj-1395Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSНизкомолекулярные гиалуронаты: биологическое действие, эффективность, безопасность и клинический опыт лечения болевых синдромов опорно-двигательного аппарата (обзор литературы и клинические наблюдения)Low molecular weight hyaluronates: biological action, efficacy, safety and clinical experience in the treatment of musculoskeletal pain syndromes (literature review and clinical observations)https://orcid.org/0000-0003-2527-5943СтраховМ. А.StrakhovM. A.

Максим Алексеевич Страхов

Кафедра травматологии, ортопедии и военно-полевой хирургии; кафедра травматологии и ортопедии

Россия, 117997, Москва, ул. Островитянова, 1

 Россия, 125371, Москва, Волоколамское шоссе, 91 

 Maxim Alekseevich Strakhov 

 Department of Traumatology, Orthopedics and Battlefield Surgery;  Department of Traumatology and Orthopedics 

1, Ostrovitianov Street, Moscow 117997, Russia;

91, Volokolamskoye Shosse, Moscow 125371, Russia 

kt8@inbox.ruhttps://orcid.org/0000-0001-7017-0898АлексееваЛ. И.AlekseevaL. I.

кафедра ревматологии 

Россия, 115522, Москва, Каширское шоссе, 34А

Россия, 125993, Москва, ул. Баррикадная, 2/1, стр.1 

Department of Rheumatology

34A, Kashirskoe Shosse, Moscow 115522, Russia;

2/1, Barrikadnaya Street, Build. 1, Moscow 125993, Russia 

 

https://orcid.org/0000-0001-9787-2048МаремкуловК. К.MaremkulovK. K.

 Россия, 105120, Москва, ул. Земляной Вал, 53, стр. 8 

 53, Zemlyanoy Val Street, Build. 8, Moscow 105120, Russia 

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; Академии постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства»РоссияPirogov Russian National Research Medical University; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Medical and Biological AgencyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional EducationRussian FederationКлиника спортивной медицины «Ортека»РоссияClinic of sports medicine "Orteka"Russian Federation20231702202317193–100Copyright © Страхов М.А., Алексеева Л.И., Маремкулов К.К., 20232023Страхов М.А., Алексеева Л.И., Маремкулов К.К.Strakhov M.A., Alekseeva L.I., Maremkulov K.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1395

Препараты гиалуроновой кислоты (ГлК) прочно вошли в комплексное лечение остеоартрита (ОА). Они обладают не только любрикантными, но и противовоспалительными свойствами, способностью замедлять прогрессирование ОА. В статье обобщены современные данные об эффективности и безопасности низкомолекулярной ГлК. Рассмотрены возможности применения ее как внутрисуставно (в/с), так и для лечения тендинопатий. Представлен собственный клинический опыт лечения пациентов с болевыми синдромами опорно-двигательного аппарата (ОДА).Показано, что при в/с введении ГлК способна эффективно снижать интенсивность боли и улучшать функцию суставов, а при введении в синовиальные влагалища сухожилий также купировать болевой синдром внесуставной локализации. Описаны особенности хирургической техники, подготовки к манипуляции и ведения постинъекционного периода.Существующая доказательная база свидетельствует о целесообразности активного применения препаратов ГлК для лечения не только ОА, но и различных внесуставных болевых синдромов ОДА.

Hyaluronic acid (HA) drugs are ingrained in complex treatment of osteoarthritis (OA). They have not only lubricant, but also anti-inflammatory properties, and ability to slow down the progression of OA. The article summarizes current data on the efficacy and safety of low molecular weight HA. The possibilities of using it both intra-articularly (i/a) and for the treatment of tendinopathies are considered. The authors present their own clinical experience in the treatment of patients with musculoskeletal (MS) pain syndromes.It has been shown that i/a administration of HA can effectively reduce the intensity of pain and improve joint function, and when injected into the synovial sheaths of tendons, it can also relieve pain of extra-articular localization. The peculiarities of the surgical technique, preparing for manipulation and post-injection period management are described.The existing evidence base indicates the expediency of active use of HA drugs not only for OA treatment, but also for various extra-articular musculoskeletal pain syndromes.

остеоартритпрепараты гиалуроновой кислотынизкомолекулярные гиалуронатывнесуставное введение гиалуронатовosteoarthritishyaluronic acid preparationslow molecular weight hyaluronatesextra-articular injection of hyaluronatesСтатья спонсируется компанией Fidia Pharma Russia LLCThe article is sponsored by Fidia Pharma Russia LLC.ReferencesValachova K, Soltes L. Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine. Int J Mol Sci. 2021 Jun 30;22(13):7077. doi: 10.3390/ijms22137077.Valachova K, Soltes L. Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine. Int J Mol Sci. 2021 Jun 30;22(13):7077. doi: 10.3390/ijms22137077.Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019 Jun 25;6:192. doi: 10.3389/fvets.2019.00192.Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. 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The authors declare that there are no conflicts of interest present.