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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2023-1-101-107</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1396</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Аксиальный спондилоартрит и COVID-19: течение, взаимодействие, исходы и роль вакцинации</article-title><trans-title-group xml:lang="en"><trans-title>Axial spondyloarthritis and COVID-19: course, interactions, outcomes, and the role of vaccination</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3195-5187</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эрдес</surname><given-names>Ш. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Erdes</surname><given-names>Sh. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Шандор Федорович Эрдес</p><p> Россия, 115522, Москва, Каширское шоссе, 34А </p></bio><bio xml:lang="en"><p> Shandor Fedorovich Erdes </p><p> 34A, Kashirskoe Shosse, Moscow 115522, Russia </p></bio><email xlink:type="simple">123456_57@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7091-2054</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белов</surname><given-names>Б. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Belov</surname><given-names>B. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Россия, 115522, Москва, Каширское шоссе, 34А </p></bio><bio xml:lang="en"><p> 34A, Kashirskoe Shosse, Moscow 115522, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>17</day><month>02</month><year>2023</year></pub-date><volume>17</volume><issue>1</issue><elocation-id>101–107</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Эрдес Ш.Ф., Белов Б.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Эрдес Ш.Ф., Белов Б.С.</copyright-holder><copyright-holder xml:lang="en">Erdes S.F., Belov B.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1396">https://mrj.ima-press.net/mrj/article/view/1396</self-uri><abstract><p>В обзоре проанализированы данные о течении и исходах аксиального спондилоартрита (аксСпА), накопленные за предшествующие 2,5 года пандемии CОVID19. Рассмотрены вопросы клинической и иммунологической эффективности вакцинации от COVID-19 при данном заболевании. Отмечено, что наличие аксСпА, а также лечение ингибиторами фактора некроза опухоли á и нестероидными противовоспалительными препаратами значимо не повышают риск заражения COVID-19 и не утяжеляют его исходы, за исключением увеличения частоты венозных тромбоэмболий. В то же время предполагается, что антицитокиновая терапия при спондилоартритах (СпА) может предохранять от тяжелого течения COVID-19.Представленные данные свидетельствуют о том, что польза вакцинации при СПА значительно превосходит потенциальный вред, связанный с развитием нежелательных явлений. Показано, что у больных СпА вакцинация не влияет на активность воспалительного процесса, а генно-инженерные биологические препараты практически не оказывают значимого воздействия на поствакцинальный ответ.</p></abstract><trans-abstract xml:lang="en"><p>The review analyzes data on the course and outcomes of axial spondyloarthritis (axSpA) accumulated over the previous 2.5 years of the COVID-19 pandemic. The issues of clinical and immunological efficacy of vaccination against COVID-19 in this disease are considered. It was noted that the presence of axSpA, as well as treatment with tumor necrosis factor-á inhibitors and non-steroidal anti-inflammatory drugs, did not significantly increase the risk of COVID-19 infection and did not worsen its outcomes, apart from an increase in the incidence of venous thromboembolism. At the same time, it is assumed that anticytokine therapy for SpA may protect against severe COVID-19 course.The data presented suggest that the benefits of vaccination in SpA far outweigh the potential harms associated with the development of adverse events. It has been shown that in patients with SpA, vaccination does not affect the activity of the inflammatory process, and biologic disease modifying antirheumatic drugs have almost no significant effect on the post-vaccination response.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аксиальный спондилоартрит</kwd><kwd>анкилозирующий спондилит</kwd><kwd>COVID-19</kwd><kwd>вакцинация</kwd><kwd>исходы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>axial spondyloarthritis</kwd><kwd>ankylosing spondylitis</kwd><kwd>COVID-19</kwd><kwd>vaccination</kwd><kwd>outcomes</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проводилось в рамках научных тем №1021051503137-7 и №1021051503111-9.</funding-statement><funding-statement xml:lang="en">The investigation has been conducted within scientific topics №1021051503137-7 and №1021051503111-9.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Letko M, Marzi A, Munster V. 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