mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/19967012-2023-2-100-108mrj-1417Research ArticleОБЗОРЫREVIEWSКлинические варианты поражения кожи и слизистых оболочек при системной красной волчанке с ювенильным началомClinical variants of skin and mucous membrane lesions in systemic lupus erythematosus with juvenile onsethttps://orcid.org/0000-0002-0513-6826КаледаМ. И.KaledaM. I.

Мария Игоревна Каледа

115522, Москва, Каширское шоссе, 34А

Maria Igorevna Kaleda

34A, Kashirskoe Shosse, Moscow 115522

kaleda-mi@yandex.ruhttps://orcid.org/0000-0003-3689-431XСалугинаС. О.SaluginaS. O.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0003-1842-0348НикишинаИ. П.NikishinaI. P.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-4156-5062АрефьеваА. Н.ArefievaA. N.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202322042023172100108Copyright © Каледа М.И., Салугина С.О., Никишина И.П., Арефьева А.Н., 20232023Каледа М.И., Салугина С.О., Никишина И.П., Арефьева А.Н.Kaleda M.I., Salugina S.O., Nikishina I.P., Arefieva A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1417

При ювенильном дебюте системной красной волчанки (СКВ) часто встречается поражение кожи и слизистых оболочек, которое характеризуется чрезвычайным разнообразием. Кожные проявления могут быть начальным признаком заболевания, нередко они одними из первых реагируют на адекватно назначенную терапию, а рецидив либо возникновение нового типа поражения у многих больных является самым ранним показателем обострения. В тяжелых случаях поражение кожи может приводить к необратимым косметическим дефектам, существенно влияя на качество жизни. В статье представлены клинические проявления различных вариантов поражения кожи и слизистых оболочек при СКВ с дебютом в детском и подростковом возрасте, распознавание которых важно для своевременной диагностики СКВ, а также коррекции терапии уже имеющегося заболевания, что позволяет улучшить отдаленный прогноз и качество жизни пациентов.

Skin and mucous membrane lesions are frequently seen in systemic lupus erythematosus (SLE) with the juvenile onset (juSLE), and they are extremely diverse. Skin manifestations can be the initial sign of the disease, they often respond first to adequate therapy, and recurrence or the appearance of a new type of lesions is the earliest indicator of exacerbation in many patients. In severe cases, skin lesions can lead to irreversible cosmetic defects, significantly affecting the quality of life. The article presents the clinical manifestations of various variants of skin and mucous membrane lesions in SLE with a debut in childhood and adolescence, their recognition is important for the timely diagnosis of SLE, as well as the correction of therapy for an existing disease, which improves the long-term prognosis and quality of life of patients.

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The authors declare that there are no conflicts of interest present.