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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2023-3-121-128</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1441</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОВЕТ ЭКСПЕРТОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERT ADVICE</subject></subj-group></article-categories><title-group><article-title>Комбинированное использование нестероидных противовоспалительных препаратов и симптоматических средств замедленного действия при болезнях костно-мышечной системы</article-title><trans-title-group xml:lang="en"><trans-title>Combined use of non-steroidal anti-inflammatory drugs and symptomatic slow-acting drugs in musculoskeletal diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1391-0711</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каратеев</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Karateev</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каратеев Андрей Евгеньевич,</p><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>Karateev Andrey Evgenievich,</p><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">aekarat@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А;</p><p>кафедра ревматологии, 125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522;</p><p>Department of Rheumatology, 2/1, Barrikadnaya Street, Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1992-7960</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парфенов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Parfenov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119021, Москва, ул. Россолимо, 11, стр. 1</p></bio><bio xml:lang="en"><p>11, Rossolimo Street, Build. 1, Moscow 119021</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хохлова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Khokhlova</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2527-5943</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Страхов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Strakhov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Островитянова, 1;</p><p>125371, Москва, Волоколамское шоссе, 91</p></bio><bio xml:lang="en"><p>1, Ostrovitianov Street, Moscow 117997;</p><p>91, Volokolamskoe Shosse, Moscow 125371</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Russian Medical Academy of Continuing Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России;&#13;
Академия постдипломного образования ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University, Ministry of Health of Russia;&#13;
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>13</day><month>07</month><year>2023</year></pub-date><volume>17</volume><issue>3</issue><fpage>121</fpage><lpage>128</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каратеев А.Е., Лила А.М., Парфенов В.А., Хохлова М.Н., Страхов М.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Каратеев А.Е., Лила А.М., Парфенов В.А., Хохлова М.Н., Страхов М.А.</copyright-holder><copyright-holder xml:lang="en">Karateev A.E., Lila A.M., Parfenov V.A., Khokhlova M.N., Strakhov M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1441">https://mrj.ima-press.net/mrj/article/view/1441</self-uri><abstract><p>Болезни костно-мышечной системы, такие как остеоартрит (ОА), неспецифическая боль в спине (НБС) и патология околосуставных мягких тканей (ПОМТ – тендинит, энтезит, бурсит и др.), – одна из наиболее частых причин обращения к врачам общей практики. Лечение этой патологии основывается на комплексном применении медикаментозных и немедикаментозных методов с целью максимально полного контроля боли и восстановления утраченной функции. Учитывая общность патогенеза скелетно-мышечной боли при ОА, НБС и ПОМТ, терапию данных заболеваний целесообразно основывать на едином алгоритме. Конечно, при назначении лечения следует учитывать «красные флаги» (симптомы угрожающих здоровью и жизни заболеваний), особенности клинического течения, психоэмоционального настроя пациента и коморбидный фон.</p><p>Формирование единой тактики лечения скелетно-мышечной боли позволит существенно сократить затраты времени на проведение диагностического поиска и выбор адекватной терапии, что облегчит работу врача общей практики. Так, наиболее рациональным в дебюте терапии ОА, НБС и ПОМТ представляется использование немедикаментозных подходов (обучение пациента, кинезиотерапия, психотерапевтические методы и др.), нестероидных противовоспалительных препаратов (НПВП) и симптоматических средств замедленного действия (SYSADOA). Среди НПВП одним из оптимальных препаратов по соотношению эффективности и безопасности представляется целекоксиб, среди SYSADOA – диацереин. Имеются данные о том, что комбинированное применение этих препаратов может повысить их анальгетический и противовоспалительный потенциал.</p></abstract><trans-abstract xml:lang="en"><p>Musculoskeletal diseases, such as osteoarthritis (OA), nonspecific back pain (NBP), and periarticular soft tissue pathology (PSTP – tendinitis, enthesitis, bursitis, etc.) are one of the most common reasons for visiting general practitioners. The treatment of this pathology is based on the complex use of drugs and non-drug methods for maximum pain control and lost function restoration. Considering the common pathogenesis of musculoskeletal pain in OA, NBP, and PSTP, it is advisable to base the therapy of these diseases on a single algorithm. Of course, when prescribing treatment, one should take into account "red flags" (symptoms of life threatening diseases), features of the clinical course, patient's psycho-emotional condition, and comorbid diseases.</p><p>Development of a unified tactic for the treatment of musculoskeletal pain will significantly reduce the time spent on a diagnostic search and the choice of adequate therapy, which will facilitate the work of a general practitioner. Thus, non-drug approaches (patient education, kinesiotherapy, psychotherapeutic methods, etc.), non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic slow-acting drugs (SYSADOA) seem to be the most rational approach in the debut of the treatment of OA, NBP and PSTP. Among NSAIDs, celecoxib seems to be one of the optimal drugs in terms of efficacy and safety, and among SYSADOAs – diacerein. There is evidence that the combined use of these drugs may increase their analgesic and anti-inflammatory potential.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>неспецифическая боль в спине</kwd><kwd>патология околосуставных мягких тканей</kwd><kwd>терапия</kwd><kwd>немедикаментозные методы</kwd><kwd>целекоксиб</kwd><kwd>диацереин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>nonspecific back pain</kwd><kwd>periarticular soft tissue pathology</kwd><kwd>therapy</kwd><kwd>non-drug methods</kwd><kwd>celecoxib</kwd><kwd>diacerein</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">https://rosstat.gov.ru/storage/mediabank/Zdravoohran-2021.pdf</mixed-citation><mixed-citation xml:lang="en">https://rosstat.gov.ru/storage/mediabank/Zdravoohran-2021.pdf</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лила АМ, Мазуров ВИ, Мартынов АИ и др. 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