mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2008-463mrj-148Research ArticleСтатьиArticlesНестероидные противовоспалительные препаратыв современной клинической практике: «за» больше, чем «против»Nonsteroidal anti-inflammatory drugs in present-day clinical practice: pro more than conКаратеевАндрей ЕвгеньевичKarateevA E-KarateyevA YeKarateyevA Ye-20081503200821№1 (2008)7078Copyright © Каратеев А.Е., Karateyev A.Y., 20082008Каратеев А.Е., Karateyev A.Y.Karateev A.E., Karateyev A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/148References<div><p>Myers A. Salicin in acute rheumatism. Lancet 1876; 2:676-7.</p><p>Насонов Е.Л., Лазебник Л.Б., Мареев В.Ю. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М., 2006.</p><p>Овечкин А.М., Свиридов С.В. Послеоперационная боль и обезболивание: современное состояние проблемы. Региональная анестезия и лечение острой боли. 2006; 1: 61-75.</p><p>Rainsford K. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin 2006; 22(6): 1161-70.</p><p>Rainer T.H. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. BMJ 2000; 321: 1247-51.</p><p>Innes G.D., Groskerry P., Worhigton J. et al. Ketorolac versus acetaminophen-codeine in the emergancy department of acute pain. J Emerg Med 1998; 16: 549-56.</p><p>Calmet J., Esteve C., Boada S. et al Analgesic effect of intra-articular ketorolac in knee arthroscopy: comparison of morphine and bupivacaine. Knee Surg. Sports Traumatol. Arthrosc 2004; 12: 552-5.</p><p>Gillis J., Brogden R. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetics and therapeutics use in pain management. Drug 1997; 53: 139-88.</p><p>Forrest J.B., Camu F., Greer I.A. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. British J Anaesth 2002; 88: 227-33.</p><p>Henderson S.O., Swadron S., Newton E. Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. J Emerg Med 2002; 23: 237-41.</p><p>Martin Carrasco C., Rodriquez Vasquez M., Palacios Garsia R. A double-blind study of analgesic efficacy in kidney colic of the combination of dipyrone and spasmolytic with ketorolac trometamol. Arch Esp Urol 1993; 46: 763-8.</p><p>Gonzalez-Garcia C.A., Ibarra-Ibarra L.G., Barbosa-Vivanco S. Comparative study of ketoralac and dipyrone administered orally in the treatment of postoperative pain. Proc West Pharacol Soc 1994; 37: 121-2 (abstract).</p><p>Верткин А.А., Вовк Е.И., Наумов А.В. и др. Некоторые вопросы дифференциального назначения лекарственных препаратов для терапии острой боли. На сайте: www.intensive.ru <http://www.intensive.ru></p><p>Бунчук Н.В. Анкилозирующий спондилит: новые возможности и перспективы фармакотерапии. Фарматека 2006; 6: 26-31.</p><p>Wanders A., Heijde D., Landewe R. et al. Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 2005; 52: 1756-65.</p><p>Van Talder M., Scholten R., Koes B. et al. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev 2000; 2: CD000369.</p><p>Singh G. Recent consideration in nons-teroidal anti-inflammatory drug gastropathy. Am J Med 1998; 105: 31-8.</p><p>Lain L. Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs-nice or necessery? Rew Gastroenterol Dis 2004; 4: 33-41.</p><p>Lanas A. Prevention and treatment of NSAID-induced gastrointestinal injury. Curr Treat Options Gastroenterol 2006; 9: 147-56.</p><p>Dubois R., Melmed G., Henning J., Lane L. Guidelines for the appropriate use of non-steroidal anti-inflammatory drugs, cyclooxygenase-2 specific inhibitors and proton pump inhibitors in patients requiring chronic anti-inflammatory therapy. Aliment Pharmacol Ther 2004; 19: 197-208.</p><p>Rainsford KD. Current status of the therapeutic uses and actions of the preferential cyclooxygenase-2 NSAID, nimesulide. Inflammopharmacology 2006; 14(3-4): 120-37.</p><p>Насонов Е.Л. Эффективность и переносимость нестероидного противовоспалительного препарата. Нимесулид: новые данные. РМЖ 2001; 15: 6-8.</p><p>Bennett A. Nimesulide a well established cyclooxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases. In: Therapeutic Roles of Selective COX-2 Inhibitors. Editors Vein J.R., Botting R.M. William Harvey Press: 524-40.</p><p>Wober W.Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. Rheumatology (Oxford) 1999; 38 (suppl. 1): 33-8.</p><p>Wober W., Rahlfs V., Buchl N. et al. Comparative efficacy and safety of the non-steroidal anti-inflammatory drugs nimesulide and diclofenac in patients with acute subdeltoid bursitis and bicipital tendinitis. Int J Clin Pract 1998; 52(3): 169-75.</p><p>Pohjolainen T., Jekunen A., Autio L. et al. Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, doubleblind comparative trial versus ibuprofen. Spine 2000; 25(12): 1579-85.</p><p>Барскова В.Г., Якунина И.А., Насонова В.А. Применение нимесила при подагрическом артрите. Тер арх 2003; 5, 60-4.</p><p>Kullich W., Niksic F., Klein G. Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study. Int J Clin Pract 2002; suppl. 128: 24-30.</p><p>Huskisson E., Macciocchi A., Rahlfs V. et al. Nimesulide versus diclofenac in the treatment of osteoarthritis of the hip or knee: an active controlled equivalence study. Curr Ther Res 1999; 60, 253-65.</p><p>Bianchi M., Broggini M. A randomized, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecocxib in osteoarthritis of the knee. Drag 2003; 63 (suppl. 1): 37-46.</p><p>Каратеев А.Е., Каратеев Д.Е., Лучихина Е.Л. и др. Эффективность и безопасность монотерапии высокими дозами НПВП при раннем артрите. РМЖ 2006; 16: 24-9.</p><p>Bradbury F. How important is the role of the physician in the correct use of a drug? An observational cohort study in general practice. Int J Clin Pract (suppl.) 2004; 144: 27-32.</p><p>Conforti A., Leone R., Moretti U. et al. Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area. Drug Saf 2001; 24: 1081-90.</p><p>Laporte J., Ibanez L., Vidal X. et al. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Saf 2004; 27: 411-20.</p><p>Минушкин О.Н. Использование препарата «Найз» у больных, страдающих сочетанной патологией суставов и поражением верхних отделов желудочно-кишечного тракта. Научно-практ ревматол 2003; 5: 72-6.</p><p>Каратеев А.Е., Каратеев Д.Е., Насонов Е.Л. Гастродуоденальная переносимость нимесулида (Нимесил, Berlin Chemie) у больных с язвенным анамнезом: первое проспективное исследование безопасности селективных ЦОГ-2 ингибиторов у больных с высоким риском развития НПВП-индуцированных гастропатий. Научно-практ ревматол 2003; 1: 45-8.</p><p>Helin-Salmivaara A., Virtanen A., Veslainen R. et al. NSAID use and the risk of hospitalisation for first myocardial infarction in the general population: a national case-control study from Finland. Eur Heart 2006; 27: 1657-63.</p><p>Барскова В.Г., Насонова В.А., Цапина Т.Н. и др. Эффективность и безопасность применения нимесила у больных с подагрическим артритом. Клин мед 2004; 82 (12): 49-54.</p><p>Каратеев А.Е., Насонов Е.Л. НПВП-ассоциированная патология ЖКТ: реальное состояние дел в России. РМЖ 2006; 15: 1073-78.</p><p>Smolley W., Stein C., Arbogast P. et al. Underutilization of gastroprotective measures in patients receiving nonsteroidal antiinflammatory drugs. Arthritis Rheum 2002; 46: 2195-280.</p><p>Sturkenboom M., Burke T., Dieleman J. et al. Underutilization of preventive strategies in patients receiving NSAIDs. Rheumatology (Oxford) 2003; 42: 23-31.</p><p>European Medicines Evaluation Agency, Committee for Proprietary Medicinal Products. Nimesulide containing medicinal products. CPMP/1724/04. <http://www.emea.eu.int></p><p>Каратеев А.Е., Насонова ВА НПВП-ассоциированная гепатопатия: проблема нимесулида. Научно-практ ревматол 2004; 1: 34-7.</p><p>Lazerow S., Abdi M., Lewis J. Drug-induced liver disease 2004. Curr Opin Gastroenterol 2005;21(3):283-92.</p><p>Larson A., Polson J., Fontana R. et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42(6):1364-72.</p><p>HELSINN's response. На сайте: HELSINN, 2002, 12. <http://www.pharmabiz.com>.</p><p>Boelsterli U. Nimesulide and hepatic adverse affects: roles of reactive metabolites and host factors. Int J Clin Pract. 2002 suppl. 128: 30-6.</p><p>Banks A., Zimmerman H., Isshak K. et al. Diclofenak-associated hepatotoxicity: analysis of 180 cases report to the Food and Drug Administration as adverse reactions. Hepatology 1995; 22: 820-70.</p><p>Traversa G., Bianchi C., Da Cas R., et al. Cohort study of hepatotoxity associated with nimesulide and other non-steroidal antiinflammatory drugs. BMJ 2003; 327: 18-22.</p><p>Каратеев А.Е., Барскова В.Г. Безопасность нимесулида: эмоции или взвешенная оценка? Consilium medicum 2007; 9: 60-4.</p><p>Rainsford K. An analysis from clinico-epidemiological data of the principal adverse events from the COX-2 selective NSAID, nimesulide, with particular reference to hepatic injury. Inflammo - pharmacology 1998; 6: 203-21.</p></div><br /><div><p>Myers A. Salicin in acute rheumatism. Lancet 1876; 2:676-7.</p><p>Насонов Е.Л., Лазебник Л.Б., Мареев В.Ю. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М., 2006.</p><p>Овечкин А.М., Свиридов С.В. Послеоперационная боль и обезболивание: современное состояние проблемы. Региональная анестезия и лечение острой боли. 2006; 1: 61-75.</p><p>Rainsford K. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin 2006; 22(6): 1161-70.</p><p>Rainer T.H. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. BMJ 2000; 321: 1247-51.</p><p>Innes G.D., Groskerry P., Worhigton J. et al. Ketorolac versus acetaminophen-codeine in the emergancy department of acute pain. J Emerg Med 1998; 16: 549-56.</p><p>Calmet J., Esteve C., Boada S. et al Analgesic effect of intra-articular ketorolac in knee arthroscopy: comparison of morphine and bupivacaine. Knee Surg. Sports Traumatol. Arthrosc 2004; 12: 552-5.</p><p>Gillis J., Brogden R. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetics and therapeutics use in pain management. Drug 1997; 53: 139-88.</p><p>Forrest J.B., Camu F., Greer I.A. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. British J Anaesth 2002; 88: 227-33.</p><p>Henderson S.O., Swadron S., Newton E. Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. J Emerg Med 2002; 23: 237-41.</p><p>Martin Carrasco C., Rodriquez Vasquez M., Palacios Garsia R. A double-blind study of analgesic efficacy in kidney colic of the combination of dipyrone and spasmolytic with ketorolac trometamol. Arch Esp Urol 1993; 46: 763-8.</p><p>Gonzalez-Garcia C.A., Ibarra-Ibarra L.G., Barbosa-Vivanco S. Comparative study of ketoralac and dipyrone administered orally in the treatment of postoperative pain. Proc West Pharacol Soc 1994; 37: 121-2 (abstract).</p><p>Верткин А.А., Вовк Е.И., Наумов А.В. и др. Некоторые вопросы дифференциального назначения лекарственных препаратов для терапии острой боли. На сайте: www.intensive.ru <http://www.intensive.ru></p><p>Бунчук Н.В. Анкилозирующий спондилит: новые возможности и перспективы фармакотерапии. Фарматека 2006; 6: 26-31.</p><p>Wanders A., Heijde D., Landewe R. et al. Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 2005; 52: 1756-65.</p><p>Van Talder M., Scholten R., Koes B. et al. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev 2000; 2: CD000369.</p><p>Singh G. Recent consideration in nons-teroidal anti-inflammatory drug gastropathy. Am J Med 1998; 105: 31-8.</p><p>Lain L. Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs-nice or necessery? Rew Gastroenterol Dis 2004; 4: 33-41.</p><p>Lanas A. Prevention and treatment of NSAID-induced gastrointestinal injury. Curr Treat Options Gastroenterol 2006; 9: 147-56.</p><p>Dubois R., Melmed G., Henning J., Lane L. Guidelines for the appropriate use of non-steroidal anti-inflammatory drugs, cyclooxygenase-2 specific inhibitors and proton pump inhibitors in patients requiring chronic anti-inflammatory therapy. Aliment Pharmacol Ther 2004; 19: 197-208.</p><p>Rainsford KD. Current status of the therapeutic uses and actions of the preferential cyclooxygenase-2 NSAID, nimesulide. Inflammopharmacology 2006; 14(3-4): 120-37.</p><p>Насонов Е.Л. Эффективность и переносимость нестероидного противовоспалительного препарата. Нимесулид: новые данные. РМЖ 2001; 15: 6-8.</p><p>Bennett A. Nimesulide a well established cyclooxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases. In: Therapeutic Roles of Selective COX-2 Inhibitors. Editors Vein J.R., Botting R.M. William Harvey Press: 524-40.</p><p>Wober W.Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. Rheumatology (Oxford) 1999; 38 (suppl. 1): 33-8.</p><p>Wober W., Rahlfs V., Buchl N. et al. Comparative efficacy and safety of the non-steroidal anti-inflammatory drugs nimesulide and diclofenac in patients with acute subdeltoid bursitis and bicipital tendinitis. Int J Clin Pract 1998; 52(3): 169-75.</p><p>Pohjolainen T., Jekunen A., Autio L. et al. Treatment of acute low back pain with the COX-2-selective anti-inflammatory drug nimesulide: results of a randomized, doubleblind comparative trial versus ibuprofen. Spine 2000; 25(12): 1579-85.</p><p>Барскова В.Г., Якунина И.А., Насонова В.А. Применение нимесила при подагрическом артрите. Тер арх 2003; 5, 60-4.</p><p>Kullich W., Niksic F., Klein G. Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study. Int J Clin Pract 2002; suppl. 128: 24-30.</p><p>Huskisson E., Macciocchi A., Rahlfs V. et al. Nimesulide versus diclofenac in the treatment of osteoarthritis of the hip or knee: an active controlled equivalence study. Curr Ther Res 1999; 60, 253-65.</p><p>Bianchi M., Broggini M. A randomized, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecocxib in osteoarthritis of the knee. Drag 2003; 63 (suppl. 1): 37-46.</p><p>Каратеев А.Е., Каратеев Д.Е., Лучихина Е.Л. и др. Эффективность и безопасность монотерапии высокими дозами НПВП при раннем артрите. РМЖ 2006; 16: 24-9.</p><p>Bradbury F. How important is the role of the physician in the correct use of a drug? An observational cohort study in general practice. Int J Clin Pract (suppl.) 2004; 144: 27-32.</p><p>Conforti A., Leone R., Moretti U. et al. Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area. Drug Saf 2001; 24: 1081-90.</p><p>Laporte J., Ibanez L., Vidal X. et al. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Saf 2004; 27: 411-20.</p><p>Минушкин О.Н. Использование препарата «Найз» у больных, страдающих сочетанной патологией суставов и поражением верхних отделов желудочно-кишечного тракта. Научно-практ ревматол 2003; 5: 72-6.</p><p>Каратеев А.Е., Каратеев Д.Е., Насонов Е.Л. Гастродуоденальная переносимость нимесулида (Нимесил, Berlin Chemie) у больных с язвенным анамнезом: первое проспективное исследование безопасности селективных ЦОГ-2 ингибиторов у больных с высоким риском развития НПВП-индуцированных гастропатий. Научно-практ ревматол 2003; 1: 45-8.</p><p>Helin-Salmivaara A., Virtanen A., Veslainen R. et al. NSAID use and the risk of hospitalisation for first myocardial infarction in the general population: a national case-control study from Finland. Eur Heart 2006; 27: 1657-63.</p><p>Барскова В.Г., Насонова В.А., Цапина Т.Н. и др. Эффективность и безопасность применения нимесила у больных с подагрическим артритом. Клин мед 2004; 82 (12): 49-54.</p><p>Каратеев А.Е., Насонов Е.Л. НПВП-ассоциированная патология ЖКТ: реальное состояние дел в России. РМЖ 2006; 15: 1073-78.</p><p>Smolley W., Stein C., Arbogast P. et al. Underutilization of gastroprotective measures in patients receiving nonsteroidal antiinflammatory drugs. Arthritis Rheum 2002; 46: 2195-280.</p><p>Sturkenboom M., Burke T., Dieleman J. et al. Underutilization of preventive strategies in patients receiving NSAIDs. Rheumatology (Oxford) 2003; 42: 23-31.</p><p>European Medicines Evaluation Agency, Committee for Proprietary Medicinal Products. Nimesulide containing medicinal products. CPMP/1724/04. <http://www.emea.eu.int></p><p>Каратеев А.Е., Насонова ВА НПВП-ассоциированная гепатопатия: проблема нимесулида. Научно-практ ревматол 2004; 1: 34-7.</p><p>Lazerow S., Abdi M., Lewis J. Drug-induced liver disease 2004. Curr Opin Gastroenterol 2005;21(3):283-92.</p><p>Larson A., Polson J., Fontana R. et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42(6):1364-72.</p><p>HELSINN's response. На сайте: HELSINN, 2002, 12. <http://www.pharmabiz.com>.</p><p>Boelsterli U. Nimesulide and hepatic adverse affects: roles of reactive metabolites and host factors. Int J Clin Pract. 2002 suppl. 128: 30-6.</p><p>Banks A., Zimmerman H., Isshak K. et al. Diclofenak-associated hepatotoxicity: analysis of 180 cases report to the Food and Drug Administration as adverse reactions. Hepatology 1995; 22: 820-70.</p><p>Traversa G., Bianchi C., Da Cas R., et al. Cohort study of hepatotoxity associated with nimesulide and other non-steroidal antiinflammatory drugs. BMJ 2003; 327: 18-22.</p><p>Каратеев А.Е., Барскова В.Г. Безопасность нимесулида: эмоции или взвешенная оценка? Consilium medicum 2007; 9: 60-4.</p><p>Rainsford K. An analysis from clinico-epidemiological data of the principal adverse events from the COX-2 selective NSAID, nimesulide, with particular reference to hepatic injury. Inflammo - pharmacology 1998; 6: 203-21.</p></div><br />
The authors declare that there are no conflicts of interest present.