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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2024-1-76-83</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1535</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Трудности дифференциальной диагностики очаговых образований в легких у пациентки с ревматоидным артритом, получавшей анти-В-клеточную терапию ритуксимабом. Описание клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Difficulties in the differential diagnosis of focal lung lesions in a patient with rheumatoid arthritis who has received anti-B-cell therapy with rituximab. Description of a clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5285-8226</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Супрун</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Suprun</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><email xlink:type="simple">suprunmar131@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-0634-5627</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шолкина</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sholkina</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1782-7763</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Semyonova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А;</p><p>107564, Москва, Яузская аллея, 2, стр. 1А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522;</p><p>2, Yauzskaya Alley, Build. 1A, Moscow 107564</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3248-6426</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ананьева</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ananyeva</surname><given-names>L. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБНУ «Центральный научно-исследовательский институт туберкулеза»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Central Research Institute of Tuberculosis</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2024</year></pub-date><volume>18</volume><issue>1</issue><fpage>76</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Супрун М.Д., Шолкина П.А., Семенова Л.А., Ананьева Л.П., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Супрун М.Д., Шолкина П.А., Семенова Л.А., Ананьева Л.П.</copyright-holder><copyright-holder xml:lang="en">Suprun M.D., Sholkina P.A., Semyonova L.A., Ananyeva L.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1535">https://mrj.ima-press.net/mrj/article/view/1535</self-uri><abstract><p>Представлен клинический случай прогрессирования очаговых образований в легких и сложности трактовки этих изменений у пациентки с ревматоидным артритом, получавшей лечение ритуксимабом и метотрексатом. Подчеркнута сложность проблемы очаговых образований в легких при ревматических заболеваниях, охватывающей широкий спектр дисциплин клинической медицины. </p></abstract><trans-abstract xml:lang="en"><p>We present a clinical case of a patient treated with rituximab and methotrexate for rheumatoid arthritis with progressive focal lung lesions that were difficult to interpret. The complexity of the problem of focal lung lesions in rheumatic diseases, which involves a broad spectrum of clinical medical disciplines, is emphasized.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>поражение легких</kwd><kwd>туберкулема</kwd><kwd>метотрексат</kwd><kwd>ритуксимаб</kwd><kwd>компьютерная томография легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>lung lesions</kwd><kwd>tuberculoma</kwd><kwd>methotrexate</kwd><kwd>rituximab</kwd><kwd>computed tomography of the lungs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gould MK, Donington J, Lynch WR, et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. 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