mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2024-2-7-15mrj-1556Research ArticleЛЕКЦИЯLECTUREК проблеме дифференциальной диагностики при выявлении антинейтрофильных цитоплазматических антителOn the problem of differential diagnosis in the detection of antineutrophil cytoplasmic antibodieshttps://orcid.org/0000-0002-4846-5531ЕгороваО. Н.EgorovaO. N.

Ольга Николаевна Егорова

115522, Москва, Каширское шоссе, 34А

Olga Nikolaevna Egorova

34A, Kashirskoe Shosse, Moscow 115522

   

onegorova@yandex.ruТарасоваГ. М.TarasovaG. M.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-4630-3985ИсаеваБ. Г.IssaevaB. G.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0003-3051-219XДацинаА. В.DatsinaA. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0001-9482-1878ДильмановаД. С.DilmanovaD. S.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0002-0020-8464ИсаеваС. М.IssaevaS. M.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0003-1182-5967НогаеваМ. Г.NogaevaM. G.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0002-6105-7559ИсаеваА. Г.IssaevaA. G.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0002-7539-9736АманжоловаА. С.AmanzholovaA. S.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0002-6105-7559СапарбаеваМ. М.SaparbayevaM. M.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0000-0002-9825-9461АташеваА. А.AtashevaA. A.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

https://orcid.org/0009-0009-9244-6731КанапинаА. Б.KanapinaA. B.

050012, Алматы, ул. Толе би, 94

94, Tole Bi Street, Almaty 050012

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationКазахский Национальный Медицинский Университет им. С.Д. АсфендияроваКазахстанS.D. Asfendiyarov Kazakh National Medical UniversityKazakhstan2024190420241827–15Copyright © Егорова О.Н., Тарасова Г.М., Исаева Б.Г., Дацина А.В., Дильманова Д.С., Исаева С.М., Ногаева М.Г., Исаева А.Г., Аманжолова А.С., Сапарбаева М.М., Аташева А.А., Канапина А.Б., 20242024Егорова О.Н., Тарасова Г.М., Исаева Б.Г., Дацина А.В., Дильманова Д.С., Исаева С.М., Ногаева М.Г., Исаева А.Г., Аманжолова А.С., Сапарбаева М.М., Аташева А.А., Канапина А.Б.Egorova O.N., Tarasova G.M., Issaeva B.G., Datsina A.V., Dilmanova D.S., Issaeva S.M., Nogaeva M.G., Issaeva A.G., Amanzholova A.S., Saparbayeva M.M., Atasheva A.A., Kanapina A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1556

Васкулиты, ассоциированные с антинейтрофильными цитоплазматическими антителами (AНЦA), представляют собой группу системных аутоиммунных заболеваний, характеризующихся некротизирующим поражением стенок преимущественно мелких сосудов и наличием AНЦA к протеиназе 3 или миелопероксидазе. Однако повышение уровня AНЦA может наблюдаться и при других заболеваниях, в том числе аутоиммунных, злокачественных, инфекционных, что затрудняет интерпретацию клинических и лабораторных данных и требует проведения дифференциальной диагностики.

Vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA) are a group of systemic autoimmune diseases characterized by necrotizing lesions of the walls of predominantly small vessels and the presence of ANCA against proteinase 3 or myeloperoxidase. However, an increase in ANCA levels can also be observed in other diseases, including autoimmune, malignant and infectious diseases, which complicates the interpretation of clinical and laboratory data and requires a differential diagnosis.

антинейтрофильные цитоплазматические антителадиагностикаревматические заболеванияидиопатические заболевания легкихонкологические заболеванияаутоиммунная патология печенилекарственные средстваantineutrophil cytoplasmic antibodiesdiagnosticsrheumatic diseasesidiopathic lung diseasesmalignant diseasesautoimmune liver pathologydrugsСтатья подготовлена в рамках научно-исследовательской работы (№/№ государственных заданий РК 122040400024-7) и международного научного сотрудничества ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» (Россия) с Казахским Национальный Медицинским Университетом им. С.Д. Асфендиярова (Казахстан).ReferencesVan Beers JJBC, Vanderlocht J, Roozendaal C, Damoiseaux J. Detection of anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence. Methods Mol Biol. 2019:1901:47-62. doi: 10.1007/978-14939-8949-2_4.Van Beers JJBC, Vanderlocht J, Roozendaal C, Damoiseaux J. 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The authors declare that there are no conflicts of interest present.