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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2024-3-52-57</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1588</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Остеосаркопения у женщин с ревматоидным артритом: связь с нутритивным статусом и физическим состоянием</article-title><trans-title-group xml:lang="en"><trans-title>Osteosarcopenia in women with rheumatoid arthritis: association with nutritional status and physical condition</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2809-0197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добровольская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrovolskaya</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Валерьевна Добровольская</p><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>Olga Valerievna Dobrovolskaya</p><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><email xlink:type="simple">olgavdobr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7661-3124</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Феклистов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Feklistov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0961-9785</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демин</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0560-3495</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козырева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozyreva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4739-4302</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торопцова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Toroptsova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>14</day><month>06</month><year>2024</year></pub-date><volume>18</volume><issue>3</issue><fpage>52</fpage><lpage>57</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Добровольская О.В., Феклистов А.Ю., Демин Н.В., Козырева М.В., Торопцова Н.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Добровольская О.В., Феклистов А.Ю., Демин Н.В., Козырева М.В., Торопцова Н.В.</copyright-holder><copyright-holder xml:lang="en">Dobrovolskaya O.V., Feklistov A.Y., Demin N.V., Kozyreva M.V., Toroptsova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1588">https://mrj.ima-press.net/mrj/article/view/1588</self-uri><abstract><p>   Цель исследования – оценить статус питания, мышечную силу, функциональное состояние скелетной мускулатуры, физическую активность и их взаимосвязь с остеосаркопеническим фенотипом состава тела у женщин в постменопаузе с ревматоидным артритом (РА).</p><sec><title>   Материал и методы</title><p>   Материал и методы. В исследование «случай-контроль» включено 134 женщины в постменопаузе с РА, у 52 из которых по данным денситометрии имелась остеосаркопения (ОСП) и у 82 отсутствовало снижение минеральной плотности кости (МПК) и мышечной массы (средний возраст – 62,0 ± 7,2 и 59,6 ± 7,5 года соответственно; р &gt; 0,05).Проведены клинико-лабораторное обследование, тестирование мышечной силы и функционального статуса. Для определения уровня нутритивного статуса и физической активности использовались опросники MNA-SF и IPAQ.</p><p>   Результаты и обсуждение. Сниженный нутритивный статус выявлен у 51,9 % пациенток, а низкий и средний уровень физической активности – у 5,8 и 50,0 % обследованных с ОСП соответственно. Определены факторы, ассоциированные с ОСП: нутритивный статус по MNA-SF &lt; 12 баллов (отношение шансов, ОШ 2,52; 95 % доверительный интервал, ДИ 1,10–5,77; р = 0,029), употребление кальция с пищей &lt; 500 мг/сут (ОШ 3,23; 95 % ДИ 1,49–7,01; р = 0,003), уровень 25(OH)D &lt; 30 нг/мл (ОШ 4,55; 95 % ДИ 1,86–11,16; р = 0,001), занятия с умеренной физической нагрузкой (ФН) &lt; 1 ч в день (ОШ 2,67; 95 % ДИ 1,06–6,75; р = 0,037), пешие прогулки &lt; 1 ч в день и &lt; 4 ч в неделю (ОШ 3,25; 95 % ДИ 1,26–8,38; р = 0,015 и ОШ 3,17; 95 % ДИ 1,19–8,46; р = 0,021 соответственно).</p></sec><sec><title>   Заключение</title><p>   Заключение. Сниженный нутритивный статус выявлен у 51,9 %, а средний или низкий уровень физической активности – у 55,8 % пациенток с ОСП. Риск развития ОСП повышался при сниженном нутритивном статусе, недостаточном употреблении кальция с пищей, низком уровне витамина D, небольшой продолжительности ежедневных занятий с умеренной ФН и недостаточном ежедневном и еженедельном времени пеших прогулок.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Objective</title><p>   Objective: to evaluate nutritional status, muscle strength, functional status of skeletal muscles and physical activity (PHA) and their relationship with the osteopenic body composition phenotype in women in post menopause with rheumatoid arthritis (RA).</p></sec><sec><title>   Material and methods</title><p>   Material and methods. The case-control study included 134 women in post menopause with RA, 52 of them had osteosarcopenia (OSP) according to densitometry and 82 had no decrease in bone mineral density (BMD) and muscle mass (mean age 62.0 ± 7.2 and 59.6 ± 7.5 years, respectively; p &gt; 0.05). A clinical and laboratory examination as well as tests to assess muscle strength and functional status were performed. The MNA-SF and IPAQ questionnaires were used to determine nutritional status and physical activity.</p><p>   Results and discussion. Malnutrition was found in 51.9 % of patients, and low and average levels of PHA were found in 5.8 and 50.0 % of patients with OSP, respectively. Factors associated with OSP were identified: nutritional status according to MNA-SF &lt; 12 points (odds ratio, OR 2.52; 95 % confidence interval, CI 1.10–5.77; p = 0.029), dietary calcium intake &lt; 500 mg/day (OR 3.23; 95 % CI 1.49–7.01; p = 0.003), 25(OH)D level &lt; 30 ng/ml (OR 4.55; 95 % CI 1.86–11.16; p = 0.001), moderate PHA &lt; 1 hour per day (OR 2.67; 95 % CI 1.06–6.75; p = 0.037), walking &lt; 1 hour per day and &lt; 4 hours per week (OR 3.25; 95 % CI 1.26–8.38; p = 0.015 and OR 3.17; 95 % CI 1.19–8.46; p = 0.021, respectively).</p></sec><sec><title>   Conclusion</title><p>   Conclusion. Reduced nutritional status was found in 51.9 % and average or low levels of PHA in 55.8 % of patients with OSP. The risk of OSP development was increased by low nutritional status, inadequate dietary calcium intake, low vitamin D levels, short duration of daily moderate exercise, and inadequate daily and weekly walking time.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>остеопороз</kwd><kwd>саркопения</kwd><kwd>остеосаркопения</kwd><kwd>нутритивный статус</kwd><kwd>физическая активность</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>osteoporosis</kwd><kwd>sarcopenia</kwd><kwd>osteosarcopenia</kwd><kwd>nutritional status</kwd><kwd>physical activity</kwd><kwd>risk factors</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена в рамках фундаментальной научной темы (регистрационный номер 1021051403074-2). Исследование не имело спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The article was prepared within the framework of basic research topic (registration number 1021051403074-2). The investigation has not been sponsored</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Güler-Yüksel M, Hoes J, Bultink I, Lems W. Glucocorticoids, Inflammation and Bone. Calcif Tissue Int. 2018 May;102(5):592-606. doi: 10.1007/s00223-017-0335-7. Epub 2018 Jan 8.</mixed-citation><mixed-citation xml:lang="en">Güler-Yüksel M, Hoes J, Bultink I, Lems W. Glucocorticoids, Inflammation and Bone. Calcif Tissue Int. 2018 May;102(5):592-606. doi: 10.1007/s00223-017-0335-7. Epub 2018 Jan 8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz BB, Gonzalez DA, Gannar F, et al. 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