References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2024-3-92-98

mrj-1594

Research Article

ОБЗОРЫ

REVIEWS

Выявление закономерностей влияния микробиоты на патогенетические механизмы развития системной красной волчанки

Identification of patterns of microbiota influence on the pathogenetic mechanisms of systemic lupus erythematosus development

https://orcid.org/0009-0009-0687-7982

Шайхутдинова

А. А.

Shaykhutdinova

A. A.

Альмира Альмировна; Шайхутдинова

199034; Университетская наб., 7–9; Санкт-Петербург

Almira Almirovna Shaykhutdinova

119034; 7–9, Universitetskaya Embankment; St. Petersburg

volkova4201@gmail.com

https://orcid.org/0009-0009-6628-9592

Бурбеза

Д. А.

Burbeza

D. A.

194100; ул. Литовская, 2; Санкт-Петербург

194100; 2, Litovskaya Street; St. Petersburg

https://orcid.org/0009-0006-0258-4777

Стрельченко

С. И.

Strelchenko

S. I.

197022; ул. Льва Толстого, 6–8; Санкт-Петербург

197022; 6–8, L’va Tolstogo Street; St. Petersburg

https://orcid.org/0009-0003-1514-8606

Фатхалла

К.

Fathallah

199034; Университетская наб., 7–9; Санкт-Петербург

119034; 7–9, Universitetskaya Embankment; St. Petersburg

https://orcid.org/0000-0002-9939-3443

Раевский

К. П.

Rayevsky

K. P.

194044; ул. Академика Лебедева, 6; Санкт-Петербург

194044; 6, Academician Lebedev Street; St. Petersburg

ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSt. Petersburg State UniversityRussian Federation

ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияSt. Petersburg State Pediatric Medical University, Ministry of Health of RussiaRussian Federation

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияPavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation

ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны РоссииРоссияMilitary Medical Academe named after S.M. Kirov, Russian Ministry of DefenceRussian Federation

2024

15062024

1839298

2024

Шайхутдинова А.А., Бурбеза Д.А., Стрельченко С.И., Фатхалла К., Раевский К.П.

Shaykhutdinova A.A., Burbeza D.A., Strelchenko S.I., Fathallah K., Rayevsky K.P.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/1594

Системная красная волчанка (СКВ) – сложное, многофакторное аутоиммунное заболевание, характеризующееся мультисистемным поражением организма. Хотя патогенез СКВ до конца не изучен, в многочисленных исследованиях показано, что состав микробиоты может влиять на течение заболевания. Микробиота играет ключевую роль в построении иммунной защиты и является неотъемлемой частью иммунного гомеостаза. Дисбактериоз микробиоты кишечника, полости рта и влагалища может оказать значительное влияние на развитие воспалительных и аутоиммунных заболеваний. В обзоре рассматриваются недавние исследования микробиоты, особое внимание уделено изменению состава микроорганизмов кишечника и их влиянию на СКВ. В частности, данные ряда исследований могут свидетельствовать о существовании взаимосвязи СКВ с определенными паттернами дисбиоза.

Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease characterized by multisystem involvement. Although the pathogenesis of SLE is not fully understood, numerous studies have shown that the composition of the microbiota can influence the course of the disease. The microbiota plays a key role in the development of immune defense and is an integral part of immune homeostasis. Dysbiosis of the intestinal, oral and vaginal microbiota can have a significant impact on the development of inflammatory and autoimmune diseases. The review addresses recent studies on the microbiota, with a particular focus on changes in the composition of the gut microbiota and their impact on SLE. Data from several studies suggest that there is a link between SLE and certain patterns of dysbiosis.

системная красная волчанкамикробиотадисбиозвлагалищевагинозвоспаление

systemic lupus erythematosusmicrobiotadysbiosisvaginavaginosisinflammation

Исследование не имело спонсорской поддержки

The investigation has not been sponsored

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The authors declare that there are no conflicts of interest present.