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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2024-3-114-121</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1597</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Битва стратегий: диеты против медикаментозной терапии при подагре</article-title><trans-title-group xml:lang="en"><trans-title>Battle of the strategies: diet versus drug therapy for gout</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5394-7869</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Желябина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhelyabina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Владимировна Желябина</p><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>Olga Vladimirovna Zhelyabina</p><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><email xlink:type="simple">olga-sheliabina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1191-5831</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеев</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseev</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522; Каширское шоссе, 34А; Москва</p></bio><bio xml:lang="en"><p>115522; 34A, Kashirskoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>06</month><year>2024</year></pub-date><volume>18</volume><issue>3</issue><fpage>114</fpage><lpage>121</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Желябина О.В., Елисеев М.С., Лила А.М., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Желябина О.В., Елисеев М.С., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Zhelyabina O.V., Eliseev M.S., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1597">https://mrj.ima-press.net/mrj/article/view/1597</self-uri><abstract><p>   Наилучший результат в контроле над подагрой дает комбинация диеты и медикаментозного лечения. Уратснижающая терапия, включая прием фебуксостата, демонстрирует более высокую эффективность и удобство в применении по сравнению с диетой в отношении достижения и удержания целевого уровня мочевой кислоты (МК) у пациентов с подагрой. Фебуксостат, ингибитор ксантиноксидазы, способствует уменьшению уровня МК в крови путем блокирования ее образования. Это позволяет предотвратить отложение кристаллов урата в суставах и тканях, снизить частоту и тяжесть подагрических приступов. В то же время диета с ограничением пуриновых продуктов также может оказывать определенное влияние на уровень МК. Диета может улучшить результаты медикаментозного лечения, снижая потребность в препаратах и минимизируя риск нежелательных явлений. Тем не менее без адекватной лекарственной терапии диета не принесет желаемых результатов. Поэтому фебуксостат остается предпочтительным вариантом уратснижающей терапии при подагре, особенно учитывая его доказанную эффективность у таких пациентов.</p></abstract><trans-abstract xml:lang="en"><p>   The best results in combating gout are achieved through a combination of diet and drug therapy. Urate-lowering therapy, which includes febuxostat, has been shown to be more effective and convenient than diet when it comes to achieving and maintaining target uric acid (UA) levels in gout patients. Febuxostat, a xanthine oxidase inhibitor, helps to reduce UA levels in the blood by blocking its formation. This helps prevent the deposition of urate crystals in joints and tissues and reduces the frequency and severity of gout attacks. At the same time, a diet of low purine foods may also have some effect on UA levels. Diet can improve the results of drug treatment by reducing the need for medications and minimizing the risk of side effects. However, without adequate drug therapy, diet will not produce the desired results. Therefore, febuxostat remains the preferred urate-lowering treatment option for gout, especially given its proven efficacy in these patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>подагра</kwd><kwd>диета</kwd><kwd>мочевая кислота</kwd><kwd>фебуксостат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gout</kwd><kwd>diet</kwd><kwd>uric acid</kwd><kwd>febuxostat</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена в рамках фундаментальной научной темы «Разработка междисциплинарной персонализированной модели оказания помощи пациентам с аутовоспалительными дегенеративными заболеваниями» № 1021051403074-2. Исследование не имело спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The article was prepared within the framework of the basic scientific topic “Development of an interdisciplinary personalized model of care for patients with autoinflammatory degenerative diseases” № 1021051403074-2. The investigation has not been sponsored</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Safiri S, Kolahi AA, Cross M, et al. Prevalence, Incidence, and Years Lived With Disability Due to Gout and Its Attributable Risk Factors for 195 Countries and Territories 1990-2017: A Systematic Analysis of the Global Burden of Disease Study 2017. Arthritis Rheumatol. 2020 Nov;72(11):1916-1927. doi: 10.1002/art.41404.</mixed-citation><mixed-citation xml:lang="en">Safiri S, Kolahi AA, Cross M, et al. 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