mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2024-3-122-127mrj-1598Research ArticleРЕКОМЕНДАЦИИ ЭКСПЕРТОВRECOMMENDATIONS OF THE EXPERTSТочка зрения на применение анифролумаба у больных системной красной волчанкой с недостаточной эффективностью стандартной терапии в реальной клинической практике. Комментарии российских экспертовPosition on the use of anifrolumab in patients with systemic lupus erythematosus with insufficient efficacy of standard therapy in real-life clinical practice. Comments from Russian expertshttps://orcid.org/0000-0002-1663-7810АсееваЕ. А.AseevaE. A.

Елена Александровна Асеева

115522; Каширское шоссе, 34А; Москва

Elena Aleksandrovna Aseeva

115522; 34A, Kashirskoe Shosse; Moscow

eaasseeva@mail.ruhttps://orcid.org/0000-0002-5206-1732СоловьевС. К.SolovievS. K.

115522; Каширское шоссе, 34А; Москва

115522; 34A, Kashirskoe Shosse; Moscow

https://orcid.org/0000-0003-3552-2522РешетнякТ. М.ReshetnyakT. M.

кафедра ревматологии

115522; Каширское шоссе, 34А; 125993; ул. Баррикадная, 2/1, стр. 1; Москва

Department of Rheumatology

115522; 34A, Kashirskoe Shosse; 125993; 2/1, Barrikadnaya Street, Build. 1; Moscow

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

кафедра ревматологии

115522; Каширское шоссе, 34А; 125993; ул. Баррикадная, 2/1, стр. 1; Москва

Department of Rheumatology

115522; 34A, Kashirskoe Shosse; 125993; 2/1, Barrikadnaya Street, Build. 1; Moscow

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation202416062024183122127Copyright © Асеева Е.А., Соловьев С.К., Решетняк Т.М., Лила А.М., 20242024Асеева Е.А., Соловьев С.К., Решетняк Т.М., Лила А.М.Aseeva E.A., Soloviev S.K., Reshetnyak T.M., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1598

   Системная красная волчанка (СКВ) – гетерогенное аутоиммунное заболевание, характеризующееся непредсказуемыми обострениями и исходом. Многие пациенты с СКВ, получающие стандартную терапию (СТ), не могут достичь рекомендуемой цели лечения – ремиссии или низкой активности заболевания (Lupus Low Disease Activity State, LLDAS). В настоящее времени сохраняется высокий уровень неудовлетворенности СТ СКВ, особенно длительным лечением глюкокортикоидами и иммунодепрессантами. Недавно одобренный препарат, антагонист рецептора интерферона I типа, анифролумаб (АФМ), может стать перспективным у пациентов с СКВ с недостаточным ответом на СТ. Исследования эффективности АФМ III фазы продемонстрировали более высокую частоту достижения ремиссии и низкой активности LLDAS у пациентов, получавших АФМ по сравнению с плацебо. В настоящей публикации представлены комментарии российских экспертов к статье Ю. Танака «Точка зрения на применение анифролумаба у пациентов с системной красной волчанкой с недостаточной эффективностью стандартной терапии в реальной клинической практике» («Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice»).

   Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by unpredictable exacerbations and outcome. Many SLE patients receiving standard therapy (ST) do not achieve the recommended treatment goal of remission or Lupus Low Disease Activity State (LLDAS). Currently, there is still great dissatisfaction with ST in SLE, especially with long-term treatment with glucocorticoids and immunosuppressants. The recently approved type I interferon receptor antagonist anifrolumab (AFM) may be promising in SLE patients who do not respond adequately to ST. Phase III efficacy studies of AFM have demonstrated higher remission rate and lower LLDAS activity in patients treated with AFM compared to placebo. This publication contains comments from Russian experts on the article by Y. Tanaka “Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice”.

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The authors declare that there are no conflicts of interest present.