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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2024-4-99-105</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1627</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Современные возможности лечения системной красной волчанки у детей (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Modern treatment options for systemic lupus erythematosus in children (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0513-6826</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каледа</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaleda</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522 </p></bio><email xlink:type="simple">kaleda-mi@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1842-0348</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никишина</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikishina</surname><given-names>I. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>21</day><month>08</month><year>2024</year></pub-date><volume>18</volume><issue>4</issue><fpage>99</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каледа М.И., Никишина И.П., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Каледа М.И., Никишина И.П.</copyright-holder><copyright-holder xml:lang="en">Kaleda M.I., Nikishina I.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1627">https://mrj.ima-press.net/mrj/article/view/1627</self-uri><abstract><p>Лечение системной красной волчанки с ювенильным началом (юСКВ) представляет собой сложную задачу с учетом разнообразия клинических проявлений и течения болезни, высокого риска повреждения органов. Необходимость создания отдельных принципов лечения юСКВ обоснована большей интенсификацией терапии за счет как используемых доз, так и сочетания большего числа разных препаратов у одного пациента. Однако на сегодня фундаментом лечения юСКВ является в основном экстраполяция данных, полученных в исследованиях взрослых пациентов. В обзоре отражены современные представления о спектре лекарственных препаратов, применяемых при юСКВ, особое внимание уделено эффективности, безопасности, срокам назначения терапии, а также возможным перспективам ее оптимизации. </p></abstract><trans-abstract xml:lang="en"><p>The treatment of juvenile-onset systemic lupus erythematosus (jSLE) is a complex task in view of the diversity of clinical manifestations and the course of the disease as well as the high risk of organ damage. The need to create separate therapeutic principles for jSLE is justified by the greater intensification of therapy due to both the doses used and the combination of a larger number of different drugs in a patient. However, the basis for the treatment of jSLE today is mainly the extrapolation of data obtained in studies with adult patients. The review reflects modern ideas about the spectrum of drugs used in jSLE, with particular emphasis on efficacy, safety and timing of therapy as well as possible optimization options. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>системная красная волчанка с ювенильным началом</kwd><kwd>глюкокортикоиды</kwd><kwd>генно-инженерная биологическая терапия</kwd><kwd>детский возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>juvenile onset systemic lupus erythematosus</kwd><kwd>glucocorticoids</kwd><kwd>biologic disease-modifying antirheumatic drugs</kwd><kwd>childhood</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена в рамках фундаментальной темы №1021051302580-4.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mina R, Brunner HI. 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