mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2024-6-90-97mrj-1672Research ArticleОБЗОРЫREVIEWSРоль нейтрофилов при васкулите, ассоциированном с антинейтрофильными цитоплазматическими антителамиThe role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodieshttps://orcid.org/0000-0001-8864-7623ВоркельЕ. Н.VorkelE. N.

Евгения Николаевна Воркель

115522, Москва, Каширское шоссе, 34А

Evgeniya Nikolaevna Vorkel

34A, Kashirskoe Shosse, Moscow 115522

evgenya.harlamova@yandex.ruhttps://orcid.org/0000-0003-3552-2522РешетнякТ. М.ReshetnyakT. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1

34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya Street, Build. 1, Moscow 125993

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1

34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya Street, Build. 1, Moscow 125993

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation2024141220241869097Copyright © Воркель Е.Н., Решетняк Т.М., Лила А.М., 20242024Воркель Е.Н., Решетняк Т.М., Лила А.М.Vorkel E.N., Reshetnyak T.M., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1672

Ассоциированный с антинейтрофильными цитоплазматическими антителами васкулит (ААВ) является потенциально опасным аутоиммунным заболеванием и характеризуется некротизирующим воспалением мелких кровеносных сосудов. В патогенезе AAВ как врожденный, так и адаптивный иммунитет тесно связан с функцией нейтрофилов. Изучение патогенетических механизмов активации нейтрофилов при ААВ может послужить предпосылкой для разработки более точных и современных методов лабораторной диагностики, а также новых подходов к лечению, направленных на нейтрофилы. В обзоре представлен анализ исследований, в которых рассматриваются вопросы активации нейтрофилов при ААВ.

Vasculitis associated with antineutrophil cytoplasmic antibodies (AAV) is a potentially dangerous autoimmune disease characterized by necrotizing inflammation of small blood vessels. In the pathogenesis of AAV, both innate and adaptive immunity are closely linked to neutrophil function. The study of the pathogenetic mechanisms of neutrophil activation in AAV may serve as a prerequisite for the development of more accurate and modern methods of laboratory diagnostics as well as new treatment approaches targeting neutrophils. The review presents an analysis of studies addressing the issue of neutrophil activation in AAV.

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The authors declare that there are no conflicts of interest present.