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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2025-1-91-97</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1708</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Хроническая боль и витамины группы В</article-title><trans-title-group xml:lang="en"><trans-title>Chronic pain and group B vitamins</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8529-4105</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зонова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zonova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Владимировна Зонова,</p><p>630091, Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>52, Krasny Prospect, Novosibirsk 630091</p></bio><email xlink:type="simple">elena_zonova@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7017-0898</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А;</p><p>125993, Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522;</p><p>2/1, Barrikadnaya Street, Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522;</p><p>2/1, Barrikadnaya Street, Build. 1, Moscow 125993</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology;&#13;
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>02</month><year>2025</year></pub-date><volume>19</volume><issue>1</issue><fpage>91</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зонова Е.В., Алексеева Л.И., Лила А.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Зонова Е.В., Алексеева Л.И., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Zonova E.V., Alekseeva L.I., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1708">https://mrj.ima-press.net/mrj/article/view/1708</self-uri><abstract><p>Хроническая боль (ХБ) влияет на качество жизни, увеличивает риск возникновения неинфекционных заболеваний и смертности. Боль вариабельна, и различные механизмы ее развития определяют тактику ведения пациента. Изучение патогенеза различных видов боли может служить предпосылкой для разработки более эффективных подходов к лечению. Внедрение в клиническую практику комбинаций препаратов позволяет получить лучший ответ на лечение при использовании меньших доз, что уменьшает лекарственную нагрузку и потенциальную токсичность.</p><p>В обзоре представлены исследования, в которых рассматриваются вопросы повышения эффективности терапии ХБ за счет включения в схему лечения адъювантов, в частности комплекса витаминов группы В.</p></abstract><trans-abstract xml:lang="en"><p>Chronic pain (CP) impairs quality of life and increases the risk of non-communicable diseases and mortality. Pain is variable, and different mechanisms of its development determine the tactics of patient treatment. Researching pathogenesis of different types of pain can serve as a prerequisite for the development of more effective treatment approaches. The introduction of drug combinations into clinical practice enables a better response to treatment with lower doses, thereby reducing drug burden and potential toxicity.</p><p>The review presents studies that address the question of how the efficacy of chronic pain therapy can be increased by including adjuvants in the treatment regimen, particularly a vitamin B complex.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая боль</kwd><kwd>тиамин</kwd><kwd>пиридоксин</kwd><kwd>цианокобаламин</kwd><kwd>остеоартрит</kwd><kwd>адъюванты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic pain</kwd><kwd>thiamine</kwd><kwd>pyridoxine</kwd><kwd>cyanocobalamin</kwd><kwd>osteoarthritis</kwd><kwd>adjuvants</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Raja SN, Carr DB, Cohen M, et al. 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