mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2025-2-113-118mrj-1749Research ArticleОБЗОРЫREVIEWSПарвовирусная B19 инфекция и ее роль в ревматологииParvovirus B19 infection and its role in rheumatologyhttps://orcid.org/0000-0002-0928-3911ГридневаГ. И.GridnevaG. I.

Галина Игоревна Гриднева

115522, Москва, Каширское шоссе, 34А

Galina Igorevna Gridneva

134A, Kashirskoe Shosse, Moscow 115522

gigridneva@mail.ruhttps://orcid.org/0000-0001-7091-2054БеловБ. С.BelovB. S.

115522, Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-0449-2685ТолбееваМ. С.TolbeevaM. S.

115522, Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-1833-5357АроноваЕ. С.AronovaE. S.

115522, Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202522042025192113118Copyright © Гриднева Г.И., Белов Б.С., Толбеева М.С., Аронова Е.С., 20252025Гриднева Г.И., Белов Б.С., Толбеева М.С., Аронова Е.С.Gridneva G.I., Belov B.S., Tolbeeva M.S., Aronova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1749

В статье обобщены современные данные об инфекции, вызванной парвовирусом (ПВ) В19, и ассоциированных с ней состояниях, встречающихся в ревматологической практике. Особое внимание уделено особенностям строения и репликации вируса в инфицированных клетках макроорганизма, что способствует лучшему пониманию патогенеза заболевания. Рассмотрена последовательность формирования иммунного ответа при инфицировании ПВ В19. Затронуты вопросы эпидемиологии ПВ В19-инфекции, вспышки которой регистрируются примерно каждые 3 года. Подчеркнута возможность гемоконтактного пути передачи ПВ В19 с препаратами крови. Описано течение инфекции ПВ В19 у пациентов с иммуносупрессией. Приведены особенности клинической картины, указано, что дифференциальная диагностика артрита, ассоциированного с ПВ В19, и ревматоидного артрита является весьма затруднительной при отсутствии соответствующего эпидемиологического анамнеза.

The article summarizes modern data on the parvovirus (PV) B19 infection and associated conditions in rheumatological practice. Special attention is paid to the features of the structure and replication of the virus in infected cells of macroorganism, which contributes to a better understanding of the pathogenesis of the disease. The sequence of immune response formation during infection with PV B19 is considered. The issues of epidemiology of PV B19 infection, with outbreaks recorded approximately every 3 years, areraised. The possibility of a hemocontact route of transmission of PV B19 with IV drugs is emphasized. The course of PV B19 infection in immunosuppressed patients is described. The features of the clinical picture are presented and it is pointed out that the differential diagnosis of arthritis associated with PV B19 and rheumatoid arthritis is very difficult in the absence of the relevant epidemiological anamnesis.

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The authors declare that there are no conflicts of interest present.