<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2025-3-129-136</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-1786</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОВЕТ ЭКСПЕРТОВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERT ADVICE</subject></subj-group></article-categories><title-group><article-title>Роль коллагенсодержащих средств в профилактике и лечении остеоартрита. Резолюция совета экспертов</article-title><trans-title-group xml:lang="en"><trans-title>The role of collagen-containing agents in the prevention and treatment of osteoarthritis: resolution of the expert council</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А </p><p>125993, Москва, ул. Баррикадная, 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>34A, Kashirskoye Shosse, Moscow, 115522 </p><p>2/1, Barrikadnaya Street, Build. 1, 125993 Moscow </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>129226, Москва, 1-я Леонова ул., 16 </p><p>117513, Москва, ул. Островитянова, 1, стр. 6 </p></bio><bio xml:lang="en"><p>16, 1st Leonova Street, Moscow 129226 </p><p>1, Ostrovitianova Street, Build. 6, Moscow 117513 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9648-2336</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляев</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyaev</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117513, Москва, ул. Островитянова, 1, стр. 6 </p></bio><bio xml:lang="en"><p>1, Ostrovitianova Street, Build. 6, Moscow 117513 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7017-0898</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А </p><p>125993, Москва, ул. Баррикадная, 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>34A, Kashirskoye Shosse, Moscow, 115522 </p><p>2/1, Barrikadnaya Street, Build. 1, 125993 Moscow </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8218-3223</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таскина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Taskina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Александровна Таскина </p><p>115522, Москва, Каширское шоссе, 34А </p></bio><bio xml:lang="en"><p>Elena Alexandrovna Taskina </p><p>34A, Kashirskoye Shosse, Moscow, 115522 </p></bio><email xlink:type="simple">braell@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6253-621X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>129226, Москва, 1-я Леонова ул., 16 </p><p>117513, Москва, ул. Островитянова, 1, стр. 6 </p></bio><bio xml:lang="en"><p>16, 1st Leonova Street, Moscow 129226 </p><p>1, Ostrovitianova Street, Build. 6, Moscow 117513 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1628-5093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>129226, Москва, 1-я Леонова ул., 16 </p></bio><bio xml:lang="en"><p>16, 1st Leonova Street, Moscow 129226 </p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2109-7510</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арьков</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Arykov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>105120, Москва, Земляной Вал, 53 </p></bio><bio xml:lang="en"><p>53, Zemlyanoy Val Street, Moscow 105120 </p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9694-5687</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119048, Москва, ул. Трубецкая, 8, стр. 2 </p><p>117198, Москва, ул. Саморы Машела, 1 </p></bio><bio xml:lang="en"><p>8, Trubetskaya Street, Build. 2, Moscow 119048 </p><p>1, Samory Mashela Street, Moscow 117198 </p></bio><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1449-8711</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кукес</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukes</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>109028, Москва, ул. Яузская, 11 корп. 10 </p></bio><bio xml:lang="en"><p>11, Yauzskaya Street, Build. 10, Moscow 109028 </p></bio><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2281-9936</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парастаев</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Parastaev</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117513, Москва, ул. Островитянова, 1, стр. 6 </p></bio><bio xml:lang="en"><p>1, Ostrovitianova Street, Build. 6, Moscow 117513 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» ; кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology ; Department of Rheumatology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский геронтологический научно-клинический центр; факультет дополнительного профессионального образования ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Clinical and Research Center of Gerontology ;  Faculty of Continuing Professional Education of N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>кафедра реабилитации, спортивной медицины и физической культуры ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Rehabilitation, Sports Medicine, and Physical Culture of N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Российский геронтологический научно-клинический центр ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Clinical and Research Center of Gerontology of N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ГАУЗ города Москвы «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Scientific and Practical Center for Medical Rehabilitation, Restorative and Sports Medicine of the Moscow City Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>кафедра организации и управления в сфере обращения лекарственных средств ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет) ; кафедра клинической иммунологии и аллергологии ФГБУ «НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Organization and Management in the Field of Drug Circulation, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University) ; Department of Clinical Immunology and Allergology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>Международная ассоциация клинических фармакологов и фармацевтов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>International Association of Clinical Pharmacologists and Pharmacists</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2025</year></pub-date><volume>19</volume><issue>3</issue><fpage>129</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лила А.М., Ткачева О.Н., Поляев Б.А., Алексеева Л.И., Таскина Е.А., Наумов А.В., Котовская Ю.В., Арьков В.В., Козлов И.Г., Кукес И.В., Парастаев С.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Лила А.М., Ткачева О.Н., Поляев Б.А., Алексеева Л.И., Таскина Е.А., Наумов А.В., Котовская Ю.В., Арьков В.В., Козлов И.Г., Кукес И.В., Парастаев С.А.</copyright-holder><copyright-holder xml:lang="en">Lila A.M., Tkacheva O.N., Polyaev B.A., Alexeeva L.I., Taskina E.A., Naumov A.V., Kotovskaya Y.V., Arykov V.V., Kozlov I.G., Kukes I.V., Parastaev S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/1786">https://mrj.ima-press.net/mrj/article/view/1786</self-uri><abstract><p>Представлены рекомендации экспертов, основанные на объективном анализе результатов доказательных исследований, систематических обзоров и метаанализов, а также собственном клиническом опыте использования новой категории коллагенсодержащих средств для профилактики и лечения остеоартрита.</p></abstract><trans-abstract xml:lang="en"><p>This publication presents expert recommendations based on an objective analysis of results from evidence-based studies, systematic reviews, and meta-analyses, as well as on the authors' own clinical experience in using a new category of collagen-containing agents for the prevention and treatment of osteoarthritis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>лечение</kwd><kwd>коллагенсодержащие средства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>treatment</kwd><kwd>collagen-containing agents</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья опубликована при поддержке компании АО «Нижфарм».</funding-statement><funding-statement xml:lang="en">Publication of this article has been supported by JSC Nizhpharm.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов АВ, Воробьёва НМ, Ховасова НО и др. Распространенность остеоартрита и его ассоциации с гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ. Терапевтический архив. 2021;(12):1485-1493.</mixed-citation><mixed-citation xml:lang="en">Naumov AV, Vorob'eva NM, Khovasova NO, et al. The prevalence of osteoarthritis and its association with geriatric syndromes in people over 65 years of age: data from the Russian epidemiological study EUCALYPTUS. Terapevticheskii arkhiv. 2021;(12):1485-1493. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dar QA, Schott EM, Catheline SE, et al. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS One. 2017 Apr 6;12(4):e0174705. doi: 10.1371/journal.pone.0174705. eCollection 2017.</mixed-citation><mixed-citation xml:lang="en">Dar QA, Schott EM, Catheline SE, et al. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS One. 2017 Apr 6;12(4):e0174705. doi: 10.1371/journal.pone.0174705. eCollection 2017.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Holwerda AM, van Loon LJC. The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review. Nutr Rev. 2022 May 9;80(6):1497-1514. doi: 10.1093/nutrit/nuab083.</mixed-citation><mixed-citation xml:lang="en">Holwerda AM, van Loon LJC. The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review. Nutr Rev. 2022 May 9;80(6):1497-1514. doi: 10.1093/nutrit/nuab083.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mobasheri A, Mahmoudian A, Kalvaityte U, et al. A white paper on collagen hydrolyzates and ultrahydrolyzates: potential supplements to support joint health in osteoarthritis? Curr Rheumatol Rep. 2021 Oct 30;23(11):78. doi: 10.1007/s11926-021-01042-6.</mixed-citation><mixed-citation xml:lang="en">Mobasheri A, Mahmoudian A, Kalvaityte U, et al. A white paper on collagen hydrolyzates and ultrahydrolyzates: potential supplements to support joint health in osteoarthritis? Curr Rheumatol Rep. 2021 Oct 30;23(11):78. doi: 10.1007/s11926-021-01042-6.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Daneault A, Prawitt J, Fabien Soule V, et al. Biological effect of hydrolyzed collagen on bone metabolism. Crit Rev Food Sci Nutr. 2017 Jun 13; 57(9):1922-1937. doi: 10.1080/10408398.2015.1038377.</mixed-citation><mixed-citation xml:lang="en">Daneault A, Prawitt J, Fabien Soule V, et al. Biological effect of hydrolyzed collagen on bone metabolism. Crit Rev Food Sci Nutr. 2017 Jun 13; 57(9):1922-1937. doi: 10.1080/10408398.2015.1038377.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander MR, Harrison DG. Legumain regulates regulatory T cells in hypertension. Circ Res. 2024 Jan 5;134(1):30-32. doi: 10.1161/CIRCRESAHA.123.324010. Epub 2024 Jan 4.</mixed-citation><mixed-citation xml:lang="en">Alexander MR, Harrison DG. Legumain regulates regulatory T cells in hypertension. Circ Res. 2024 Jan 5;134(1):30-32. doi: 10.1161/CIRCRESAHA.123.324010. Epub 2024 Jan 4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Puig D, Costa-Larrion E, RubioRodriguez N, Gаlvez-Martin P. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023 Mar 8;15(6):1332. doi: 10.3390/nu15061332.</mixed-citation><mixed-citation xml:lang="en">Martinez-Puig D, Costa-Larrion E, RubioRodriguez N, Gаlvez-Martin P. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023 Mar 8;15(6):1332. doi: 10.3390/nu15061332.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pavelka K, Jarosova H, Milani L, et al. Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients with Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain). Physiol Res. 2019 Nov 22;68(Suppl 1):S65-S74. doi: 10.33549/physiolres.934326.</mixed-citation><mixed-citation xml:lang="en">Pavelka K, Jarosova H, Milani L, et al. Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients with Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain). Physiol Res. 2019 Nov 22;68(Suppl 1):S65-S74. doi: 10.33549/physiolres.934326.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Schön C, Knaub K, Alt W, et al. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Integr Complement Med. 2022 Jun;28(6):540-548. doi: 10.1089/jicm.2021.0365. Epub 2022 Apr 4.</mixed-citation><mixed-citation xml:lang="en">Schön C, Knaub K, Alt W, et al. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Integr Complement Med. 2022 Jun;28(6):540-548. doi: 10.1089/jicm.2021.0365. Epub 2022 Apr 4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Knaub K, Schön C, Alt W, et al. UC-II® Undenatured Type II Collagen Reduces Knee Joint Discomfort and Improves Mobility in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Clin Trials 2022;12:1–8. doi:10.35248/2167-0870.22.12.492.</mixed-citation><mixed-citation xml:lang="en">Knaub K, Schön C, Alt W, et al. UC-II® Undenatured Type II Collagen Reduces Knee Joint Discomfort and Improves Mobility in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Clin Trials 2022;12:1–8. doi:10.35248/2167-0870.22.12.492.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48.</mixed-citation><mixed-citation xml:lang="en">Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. J Am Nutr Assoc. 2023 Mar-Apr;42(3):224-241. doi: 10.1080/07315724.2021.2024466. Epub 2022 Mar 21.</mixed-citation><mixed-citation xml:lang="en">Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. J Am Nutr Assoc. 2023 Mar-Apr;42(3):224-241. doi: 10.1080/07315724.2021.2024466. Epub 2022 Mar 21.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zdzieblik D, Brame J, Oesser S, et al. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients. 2021 Feb 5;13(2):523. doi: 10.3390/nu13020523.</mixed-citation><mixed-citation xml:lang="en">Zdzieblik D, Brame J, Oesser S, et al. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients. 2021 Feb 5;13(2):523. doi: 10.3390/nu13020523.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908x291967. Epub 2008 Apr 15.</mixed-citation><mixed-citation xml:lang="en">Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908x291967. Epub 2008 Apr 15.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bongers C, Ten Haaf D, Catoire M, et al. Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial. Appl Physiol Nutr Metab. 2020 Jul;45(7):793-800. doi: 10.1139/apnm-2019-0654. Epub 2020 Jan 28.</mixed-citation><mixed-citation xml:lang="en">Bongers C, Ten Haaf D, Catoire M, et al. Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial. Appl Physiol Nutr Metab. 2020 Jul;45(7):793-800. doi: 10.1139/apnm-2019-0654. Epub 2020 Jan 28.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kviatkovsky SA, Hickner RC, Cabre HE, et al. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023 Dec; 20(1):2243252. doi: 10.1080/15502783.2023.2243252.</mixed-citation><mixed-citation xml:lang="en">Kviatkovsky SA, Hickner RC, Cabre HE, et al. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023 Dec; 20(1):2243252. doi: 10.1080/15502783.2023.2243252.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schulze C, Schunck M, Zdzieblik D, Oesser S. Impact of Specific Bioactive Collagen Peptides on Joint Discomforts in the Lower Extremity during Daily Activities: A Randomized Controlled Trial. Int J Environ Res Public Health. 2024 May 27;21(6):687. doi: 10.3390/ijerph21060687.</mixed-citation><mixed-citation xml:lang="en">Schulze C, Schunck M, Zdzieblik D, Oesser S. Impact of Specific Bioactive Collagen Peptides on Joint Discomforts in the Lower Extremity during Daily Activities: A Randomized Controlled Trial. Int J Environ Res Public Health. 2024 May 27;21(6):687. doi: 10.3390/ijerph21060687.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bakilan F, Armagan O, Ozgen M, et al. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030.</mixed-citation><mixed-citation xml:lang="en">Bakilan F, Armagan O, Ozgen M, et al. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Scarpellini M, Lurati A, Vignati G, et al. Biomarkers, Type II Collagen, Glucosamine and Chondroitin Sulfate in Osteoarthritis Follow-up: The “Magenta Osteoarthritis Study”. J Orthop Traumatol. 2008 Jun;9(2):81-7. doi: 10.1007/s10195-008-0007-5. Epub 2008 May 28.</mixed-citation><mixed-citation xml:lang="en">Scarpellini M, Lurati A, Vignati G, et al. Biomarkers, Type II Collagen, Glucosamine and Chondroitin Sulfate in Osteoarthritis Follow-up: The “Magenta Osteoarthritis Study”. J Orthop Traumatol. 2008 Jun;9(2):81-7. doi: 10.1007/s10195-008-0007-5. Epub 2008 May 28.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Crowley DC, Lau FC, Sharma P, et al. Safety and Efficacy of Undenatured Type II Collagen in the Treatment of Osteoarthritis of the Knee: A Clinical Trial. Int J Med Sci. 2009 Oct 9;6(6): 312-21. doi: 10.7150/ijms.6.312.</mixed-citation><mixed-citation xml:lang="en">Crowley DC, Lau FC, Sharma P, et al. Safety and Efficacy of Undenatured Type II Collagen in the Treatment of Osteoarthritis of the Knee: A Clinical Trial. Int J Med Sci. 2009 Oct 9;6(6): 312-21. doi: 10.7150/ijms.6.312.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lugo JP, Saiyed ZM, Lane NE. Efficacy and Tolerability of an Undenatured Type II Collagen Supplement in Modulating Knee Osteoarthritis Symptoms: A Multicenter Randomized, DoubleBlind, Placebo-Controlled Study. Nutr J. 2016 Jan 29:15:14. doi: 10.1186/s12937-016-0130-8.</mixed-citation><mixed-citation xml:lang="en">Lugo JP, Saiyed ZM, Lane NE. Efficacy and Tolerability of an Undenatured Type II Collagen Supplement in Modulating Knee Osteoarthritis Symptoms: A Multicenter Randomized, DoubleBlind, Placebo-Controlled Study. Nutr J. 2016 Jan 29:15:14. doi: 10.1186/s12937-016-0130-8.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bagchi D, Misner B, Bagchi M, et al. Effects of Orally Administered Undenatured Type II Chicken Collagen against Arthritic Inflammatory Pathologies: A Mechanistic Exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.</mixed-citation><mixed-citation xml:lang="en">Bagchi D, Misner B, Bagchi M, et al. Effects of Orally Administered Undenatured Type II Chicken Collagen against Arthritic Inflammatory Pathologies: A Mechanistic Exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mehra A, Anand P, Borate M, et al. A NonInterventional, Prospective, Multicentric Real Life Indian Study to Assess Safety and Effectiveness of Un-Denatured Type 2 Collagen in Management of Osteoarthritis. Int J Res Orthop. 2019; 5(2):315–320. doi: 10.18203/issn.2455-4510. IntJResOrthop20190798</mixed-citation><mixed-citation xml:lang="en">Mehra A, Anand P, Borate M, et al. A NonInterventional, Prospective, Multicentric Real Life Indian Study to Assess Safety and Effectiveness of Un-Denatured Type 2 Collagen in Management of Osteoarthritis. Int J Res Orthop. 2019; 5(2):315–320. doi: 10.18203/issn.2455-4510. IntJResOrthop20190798</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Azeem MA, Patil R. The Study of Undenatured Type II Collagen in the Knee Osteoarthritis. Indjst. 2019;(5):172–175.</mixed-citation><mixed-citation xml:lang="en">Azeem MA, Patil R. The Study of Undenatured Type II Collagen in the Knee Osteoarthritis. Indjst. 2019;(5):172–175.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Costa AP, Cunha Teixeira V, Pereira M, et al. Associated Strengthening Exercises to Undenatured Oral Type II Collagen (UC-II). A Randomized Study in Patients Affected by Knee Osteoarthritis. Muscles Ligaments Tendons J. 2020;10: 481–492. doi: 10.32098/mltj.03.2020.18</mixed-citation><mixed-citation xml:lang="en">Costa AP, Cunha Teixeira V, Pereira M, et al. Associated Strengthening Exercises to Undenatured Oral Type II Collagen (UC-II). A Randomized Study in Patients Affected by Knee Osteoarthritis. Muscles Ligaments Tendons J. 2020;10: 481–492. doi: 10.32098/mltj.03.2020.18</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jain AV, Jain KA, Vijayaraghavan N. AflaB2® and Osteoarthritis: A Multicentric, Observational, Post-Marketing Surveillance Study in Indian Patients Suffering from Knee Osteoarthritis. Int J Res Orthop. 2020;7:110. doi: 10.18203/issn.2455-4510.IntJResOrthop20205570</mixed-citation><mixed-citation xml:lang="en">Jain AV, Jain KA, Vijayaraghavan N. AflaB2® and Osteoarthritis: A Multicentric, Observational, Post-Marketing Surveillance Study in Indian Patients Suffering from Knee Osteoarthritis. Int J Res Orthop. 2020;7:110. doi: 10.18203/issn.2455-4510.IntJResOrthop20205570</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rui F, Jiawei K, Yuntao H, et al. Undenatured type II collagen prevents and treats osteoarthritis and motor function degradation in T2DM patients and db/db mice. Food Funct. 2021 May 21;12(10):4373-4391. doi: 10.1039/d0fo03011b. Epub 2021 Apr 23.</mixed-citation><mixed-citation xml:lang="en">Rui F, Jiawei K, Yuntao H, et al. Undenatured type II collagen prevents and treats osteoarthritis and motor function degradation in T2DM patients and db/db mice. Food Funct. 2021 May 21;12(10):4373-4391. doi: 10.1039/d0fo03011b. Epub 2021 Apr 23.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. A Randomized Controlled Trial on the Efficacy and Safety of a Food Ingredient, Collagen Hydrolysate, for Improving Joint Comfort. Int J Food Sci Nutr. 2009: 60 Suppl 2:99-113. doi: 10.1080/09637480802498820. Epub 2009 Feb 11.</mixed-citation><mixed-citation xml:lang="en">Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. A Randomized Controlled Trial on the Efficacy and Safety of a Food Ingredient, Collagen Hydrolysate, for Improving Joint Comfort. Int J Food Sci Nutr. 2009: 60 Suppl 2:99-113. doi: 10.1080/09637480802498820. Epub 2009 Feb 11.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bernardo MLR, Azarcon AC. A Randomized Controlled Trial on the Effects of Oral Collagen Treatment on the Media) Knee Joint Space Aod Functional Outcome among Veterans Memorial Medical Center Patients Diagnosed with Osteoarthritis of the Knee. Parm. Proc. 2012;4:1–8.</mixed-citation><mixed-citation xml:lang="en">Bernardo MLR, Azarcon AC. A Randomized Controlled Trial on the Effects of Oral Collagen Treatment on the Media) Knee Joint Space Aod Functional Outcome among Veterans Memorial Medical Center Patients Diagnosed with Osteoarthritis of the Knee. Parm. Proc. 2012;4:1–8.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S, Sugihara F, Suzuki K, et al. A DoubleBlind, Placebo-Controlled, Randomised, Clinical Study on the Effectiveness of Collagen Peptide on Osteoarthritis: Effect of Collagen Peptide on Arthritis. J Sci Food Agric. 2015 Mar 15;95(4): 702-7. doi: 10.1002/jsfa.6752. Epub 2014 Jun 24.</mixed-citation><mixed-citation xml:lang="en">Kumar S, Sugihara F, Suzuki K, et al. A DoubleBlind, Placebo-Controlled, Randomised, Clinical Study on the Effectiveness of Collagen Peptide on Osteoarthritis: Effect of Collagen Peptide on Arthritis. J Sci Food Agric. 2015 Mar 15;95(4): 702-7. doi: 10.1002/jsfa.6752. Epub 2014 Jun 24.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Schauss A, Stenehjem J, Park J, et al. Effect of the Novel Low Molecular Weight Hydrolyzed Chicken Sternal Cartilage Extract, BioCell Collagen, on Improving Osteoarthritis-Related Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial. J Agric Food Chem. 2012 Apr 25;60(16):4096-101. doi: 10.1021/jf205295u. Epub 2012 Apr 16.</mixed-citation><mixed-citation xml:lang="en">Schauss A, Stenehjem J, Park J, et al. Effect of the Novel Low Molecular Weight Hydrolyzed Chicken Sternal Cartilage Extract, BioCell Collagen, on Improving Osteoarthritis-Related Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial. J Agric Food Chem. 2012 Apr 25;60(16):4096-101. doi: 10.1021/jf205295u. Epub 2012 Apr 16.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Trˇc T, Bohmova J. Efficacy and Tolerance of Enzymatic Hydrolysed Collagen (EHC) vs. Glucosamine Sulphate (GS) in the Treatment of Knee Osteoarthritis (KOA). Int Orthop. 2011 Mar;35(3):341-8. doi: 10.1007/s00264-010-1010-z. Epub 2010 Apr 19.</mixed-citation><mixed-citation xml:lang="en">Trˇc T, Bohmova J. Efficacy and Tolerance of Enzymatic Hydrolysed Collagen (EHC) vs. Glucosamine Sulphate (GS) in the Treatment of Knee Osteoarthritis (KOA). Int Orthop. 2011 Mar;35(3):341-8. doi: 10.1007/s00264-010-1010-z. Epub 2010 Apr 19.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kilinc BE, Oc Y, Alibakan G, et al. An Observational 1-Month Trial on the Efficacy and Safety of Promerim for Improving Knee Joint. Clin Med Insights Arthritis Musculoskelet Disord. 2018 Feb 11:11:1179544118757496. doi: 10.1177/1179544118757496. eCollection 2018.</mixed-citation><mixed-citation xml:lang="en">Kilinc BE, Oc Y, Alibakan G, et al. An Observational 1-Month Trial on the Efficacy and Safety of Promerim for Improving Knee Joint. Clin Med Insights Arthritis Musculoskelet Disord. 2018 Feb 11:11:1179544118757496. doi: 10.1177/1179544118757496. eCollection 2018.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Puigdellivol J, Comellas Berenger C, Perez Fernandez MБ, et al. Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients. J Diet Suppl. 2019;16(4):379- 389. doi: 10.1080/19390211.2018.1461726. Epub 2018 Apr 27.</mixed-citation><mixed-citation xml:lang="en">Puigdellivol J, Comellas Berenger C, Perez Fernandez MБ, et al. Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients. J Diet Suppl. 2019;16(4):379- 389. doi: 10.1080/19390211.2018.1461726. Epub 2018 Apr 27.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang JX, Zhou JL, Prawitt J. Collagen Peptides Improve Knee Osteoarthritis in Elderly Women: A 6-Month Randomized, DoubleBlind, Placebo-Controlled Study. Agro Food Ind Hi Tech. 2014;25:19–23.</mixed-citation><mixed-citation xml:lang="en">Jiang JX, Zhou JL, Prawitt J. Collagen Peptides Improve Knee Osteoarthritis in Elderly Women: A 6-Month Randomized, DoubleBlind, Placebo-Controlled Study. Agro Food Ind Hi Tech. 2014;25:19–23.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H. A review of the effects of collagen treatment in clinical studies. Polymers (Basel). 2021 Nov 9;13(22):3868. doi: 10.3390/polym13223868.</mixed-citation><mixed-citation xml:lang="en">Wang H. A review of the effects of collagen treatment in clinical studies. Polymers (Basel). 2021 Nov 9;13(22):3868. doi: 10.3390/polym13223868.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Fuggle N, Laslop A, Rizzoli R, et al. Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs. 2025 Mar;85(3):343-360. doi: 10.1007/s40265-024-02138-w. Epub 2025 Feb 19.</mixed-citation><mixed-citation xml:lang="en">Fuggle N, Laslop A, Rizzoli R, et al. Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs. 2025 Mar;85(3):343-360. doi: 10.1007/s40265-024-02138-w. Epub 2025 Feb 19.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов АВ, Унковский АВ, Ховасова НО и др. Комбинированная терапия обострений болевого синдрома при остеоартрите нефиксированными комбинациями. Терапевтический архив. 2025;97(5):419-426.</mixed-citation><mixed-citation xml:lang="en">Naumov AV, Unkovskiy AV, Khovasova NO, et al. Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations. Terapevticheskii Arkhiv. 2025;97(5):419- 426. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Coronado JM, Martinez-Olvera L, Elizondo-Omana RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a metaanalysis of randomized placebo-controlled trials. Int Orthop. 2019 Mar;43(3):531-538. doi: 10.1007/s00264-018-4211-5. Epub 2018 Oct 27.</mixed-citation><mixed-citation xml:lang="en">Garcia-Coronado JM, Martinez-Olvera L, Elizondo-Omana RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a metaanalysis of randomized placebo-controlled trials. Int Orthop. 2019 Mar;43(3):531-538. doi: 10.1007/s00264-018-4211-5. Epub 2018 Oct 27.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Evers BJ, Van Den Bosch MH, Blom AB, et al. Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression. Front Med (Lausanne). 2022 Aug 22:9: 973870. doi: 10.3389/fmed.2022.973870. eCollection 2022.</mixed-citation><mixed-citation xml:lang="en">Evers BJ, Van Den Bosch MH, Blom AB, et al. Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression. Front Med (Lausanne). 2022 Aug 22:9: 973870. doi: 10.3389/fmed.2022.973870. eCollection 2022.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Poole AR, Kobayashi M, Yasuda T, et al. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii78-81. doi: 10.1136/ard.61.suppl_2.ii78.</mixed-citation><mixed-citation xml:lang="en">Poole AR, Kobayashi M, Yasuda T, et al. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii78-81. doi: 10.1136/ard.61.suppl_2.ii78.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar P, Bansal P, Rajnish RK, et al. Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited metaanalysis. Am J Transl Res. 2023 Sep 15;15(9): 5545-5555. eCollection 2023.</mixed-citation><mixed-citation xml:lang="en">Kumar P, Bansal P, Rajnish RK, et al. Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited metaanalysis. Am J Transl Res. 2023 Sep 15;15(9): 5545-5555. eCollection 2023.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kharti M, Naughton RJ, Clifford T. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021 Oct;53(10):1493-1506. doi: 10.1007/s00726-021-03072-x. Epub 2021 Sep 7.</mixed-citation><mixed-citation xml:lang="en">Kharti M, Naughton RJ, Clifford T. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021 Oct;53(10):1493-1506. doi: 10.1007/s00726-021-03072-x. Epub 2021 Sep 7.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez HL, Habowski SM, Sandrock JE, et al. Effects of BioCell Collagen® on connective tissue protection and functional recovery from exercise in healthy adults: a pilot study. J Int Soc Sports Nutr. 2014; 11(1):1-2. doi:10.1186/1550-2783-11-S1-P48</mixed-citation><mixed-citation xml:lang="en">Lopez HL, Habowski SM, Sandrock JE, et al. Effects of BioCell Collagen® on connective tissue protection and functional recovery from exercise in healthy adults: a pilot study. J Int Soc Sports Nutr. 2014; 11(1):1-2. doi:10.1186/1550-2783-11-S1-P48</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Maughan RJ. IOC consensus statement: dietary supplements and the high-performance athlete. Int J Sport Nutr Exerc Metab. 2018 Mar 1; 28(2):101. doi: 10.1123/ijsnem.2018-0026. Epub 2018 Feb 14.</mixed-citation><mixed-citation xml:lang="en">Maughan RJ. IOC consensus statement: dietary supplements and the high-performance athlete. Int J Sport Nutr Exerc Metab. 2018 Mar 1; 28(2):101. doi: 10.1123/ijsnem.2018-0026. Epub 2018 Feb 14.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995:64:403-34. doi: 10.1146/annurev.bi.64.070195.002155.</mixed-citation><mixed-citation xml:lang="en">Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995:64:403-34. doi: 10.1146/annurev.bi.64.070195.002155.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Shrive NG, O’Connor PJ, Good AE. Effect of low and high molecular weight collagen hydrolysates on collagen catabolism. J Int Med Res. 2019;47(6):2332-2343.</mixed-citation><mixed-citation xml:lang="en">Shrive NG, O’Connor PJ, Good AE. Effect of low and high molecular weight collagen hydrolysates on collagen catabolism. J Int Med Res. 2019;47(6):2332-2343.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1): a004978. doi: 10.1101/cshperspect.a004978.</mixed-citation><mixed-citation xml:lang="en">Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1): a004978. doi: 10.1101/cshperspect.a004978.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Myllyharju J, Kivirikko KI. Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet. 2004 Jan;20(1): 33-43. doi: 10.1016/j.tig.2003.11.004.</mixed-citation><mixed-citation xml:lang="en">Myllyharju J, Kivirikko KI. Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet. 2004 Jan;20(1): 33-43. doi: 10.1016/j.tig.2003.11.004.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
