mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2008-494mrj-179Research ArticleСтатьиArticlesМесто локальной терапии в ревматологии. В фокусе - гель кетопрофенPlace of topical therapy in rheumatology. Ketoprofen gel is a focusБарсковаВ. Г.BarskovaV G-Il'inaA EIl'inaA E-БарсковаВ. Г.BarskovaV G-IlyinaA EIlyinaA E-20082509200823№3 (2008)7477Copyright © Барскова В.Г., Il'ina A.E., Барскова В.Г., Ilyina A.E., 20082008Барскова В.Г., Il'ina A.E., Барскова В.Г., Ilyina A.E.Barskova V.G., Il'ina A.E., Barskova V.G., Ilyina A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/179

Показано, что, по данным современных исследований, локальные формы нестероидных противовоспалительных препаратов (НПВП) при ревматических заболеваниях наибольшее значение имеют в лечении остеоартроза. Сравнительные исследования продемонстрировали преимущество геля, содержащего кетопрофен, перед другими НПВП. Формы для местного применения на основе кетопрофена (Фастум® гель) являются эффективными, быстродействующими, способными помочь пациентам в преодолении боли и улучшении качества жизни.

According to the data of recent studies, the topical formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) used in rheumatic diseases are of the greatest importance in the treatment of osteoarthrosis. Comparative studies have demonstrated that ketoprofen-containing gel has some advantage over other NSAIDs. Topical formulations based on ketoprofen (Fastum® gel) are effective, fast-acting, and able to aid patients in relieving pain and improving the quality of life.

References<div><p>Bateman D.N., Kennedy J.G. Nonsteroidal anti-inflammatory drugs and elderly patients. The medicine may be worse than the disease. BMJ 1995; 310: 817-8.</p><p>Anonimous. Rational use of NSAIDs for musculoskeletal disorders. Drug Ther Bull 1994; 32: 91-5.</p><p>Moore R.A., Tramer M.R., Carroll D. et al. Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998; 316: 333-8.</p><p>Browning R.C., Johson K. Reducing the dose of oral NSAIDs by use of feldene gel: an open study in elderly patients with osteoarthritis. Adv Ther 1994; 11: 198-206.</p><p>Golden E.L. A double-blind comparrison of oraly ingested aspirin and a topically applied salicylate cream in the relief of rheumatic pain. Cur Ther Res 1978; 24: 524-9.</p><p>Rother M., Lavins B.J., Kneer W. et al. Efficacy and safety of epicutaneous ketopro-fen in Transferome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial.</p><p>Underwood M., Ashby D., Cross P. et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ 2008; 336; 138-42.</p><p>Heyneman C.A., Lawless-Liday C., Wall G.C. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs 2000; 60(3): 555-74. Ревматология: национальное руководство. Под ред. Е.Л. Насонова, В.А. Насоновой. М.: ГЭОТАР-Медиа, 2008; 720.</p><p>Zhang W., Doherty M., Leeb B.F. et al. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2007; Mar; 66(3): 377-88.</p><p>Jordan K.M., Arden N.K., Doherty M. et al. Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003; Dec; 62(12): 1145-55.</p><p>Zhang W., Moskowitz R.W., Nuki G. et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008; Feb; 16(2): 137-62.</p><p>Zhang W., Moskowitz R.W., Nuki G. et al. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage 2007; Sep; 15(9): 981-1000.</p><p>Zhang W., Doherty M., Arden N. et al. EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; May; 64(5): 669-81.</p><p>Pendleton A., Arden N., Dougados M. et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2000; Dec; 59(12): 936-44.</p><p>Балабанова Р.М., Федина Т.П. Опыт применения геля Тизоль для локальной терапии ревматоидного артрита. Науч-практич ревматол 2004; 3: 37-40.</p><p>Балабанова Р.М., Запрягаева М.Е. Финалгель - новая лекарственная форма пи-роксикама для локальной терапии. РМЖ 2002; 10(6): 329-30.</p><p>Балабанова Р.М., Федина Т.П., Запрягаева М.Е. и др. Эффект локальной терапии гелем Найз у больных ревматоидным артритом. Современная ревматология 2008; 2: 79-82.</p><p>Медынцева Л.Г., Кузьмина Н.Н. Оценка терапевтической эффективности крема Долгит у детей с ювенильными хроническими артритами. Детская ревматология 1995; 1: 26-9.</p><p>Mason L., Moore R.A., Edwards J.E. et al. Topical NSAIDs for chronic musculoskeletal pain: systematic review and metaanalysis. BMC Musculoskelet Disord 2004; 5: 28.</p><p>Lin J., Zhang W., Jones A. et al. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled reials. BMJ 2004; 329: 324.</p><p>Carnes D., Anwer Y., Underwood M. et al. Influences on older people's decision making regarding choice of topical or oral NSAIDs for knee pain: qulitative study. BMJ 2008; Jan 19; 336(7636): 142-5.</p><p>Patel R.K., Leswell P.F. Comparison of ketoprofen, piroxicam, and diclofenac gels in the treatment of acute soft-tissue injury in general practice. General Practice Study Group. Clin Ther 1996 May-Jun; 18(3): 497-507.</p><p>Kantor T.G. Ketoprofen: a review of its pharmacological and clinical properties. Pharmacotherapy 1986; 6(3).</p><p>Kubota T., Komatsu H., Kawamoto H. et al. Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis. Arch Int Pharmacodyn Ther 1979 Jan; 237(1): 169-76.</p><p>Guyonnet J.C., Julou L. Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents. Rheumatol Rehabil. 1976; suppl.: 11-4.</p><p>Чичасова Н.В. Локальная терапия хронических заболеваний опорно-двигательного аппарата. Спр поликл врача 2007; 4(6).</p></div><br /><div><p>Bateman D.N., Kennedy J.G. Nonsteroidal anti-inflammatory drugs and elderly patients. The medicine may be worse than the disease. BMJ 1995; 310: 817-8.</p><p>Anonimous. Rational use of NSAIDs for musculoskeletal disorders. Drug Ther Bull 1994; 32: 91-5.</p><p>Moore R.A., Tramer M.R., Carroll D. et al. Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998; 316: 333-8.</p><p>Browning R.C., Johson K. Reducing the dose of oral NSAIDs by use of feldene gel: an open study in elderly patients with osteoarthritis. Adv Ther 1994; 11: 198-206.</p><p>Golden E.L. A double-blind comparrison of oraly ingested aspirin and a topically applied salicylate cream in the relief of rheumatic pain. Cur Ther Res 1978; 24: 524-9.</p><p>Rother M., Lavins B.J., Kneer W. et al. Efficacy and safety of epicutaneous ketopro-fen in Transferome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial.</p><p>Underwood M., Ashby D., Cross P. et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ 2008; 336; 138-42.</p><p>Heyneman C.A., Lawless-Liday C., Wall G.C. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs 2000; 60(3): 555-74. Ревматология: национальное руководство. Под ред. Е.Л. Насонова, В.А. Насоновой. М.: ГЭОТАР-Медиа, 2008; 720.</p><p>Zhang W., Doherty M., Leeb B.F. et al. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2007; Mar; 66(3): 377-88.</p><p>Jordan K.M., Arden N.K., Doherty M. et al. Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003; Dec; 62(12): 1145-55.</p><p>Zhang W., Moskowitz R.W., Nuki G. et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008; Feb; 16(2): 137-62.</p><p>Zhang W., Moskowitz R.W., Nuki G. et al. OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage 2007; Sep; 15(9): 981-1000.</p><p>Zhang W., Doherty M., Arden N. et al. EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005; May; 64(5): 669-81.</p><p>Pendleton A., Arden N., Dougados M. et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2000; Dec; 59(12): 936-44.</p><p>Балабанова Р.М., Федина Т.П. Опыт применения геля Тизоль для локальной терапии ревматоидного артрита. Науч-практич ревматол 2004; 3: 37-40.</p><p>Балабанова Р.М., Запрягаева М.Е. Финалгель - новая лекарственная форма пи-роксикама для локальной терапии. РМЖ 2002; 10(6): 329-30.</p><p>Балабанова Р.М., Федина Т.П., Запрягаева М.Е. и др. Эффект локальной терапии гелем Найз у больных ревматоидным артритом. Современная ревматология 2008; 2: 79-82.</p><p>Медынцева Л.Г., Кузьмина Н.Н. Оценка терапевтической эффективности крема Долгит у детей с ювенильными хроническими артритами. Детская ревматология 1995; 1: 26-9.</p><p>Mason L., Moore R.A., Edwards J.E. et al. Topical NSAIDs for chronic musculoskeletal pain: systematic review and metaanalysis. BMC Musculoskelet Disord 2004; 5: 28.</p><p>Lin J., Zhang W., Jones A. et al. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled reials. BMJ 2004; 329: 324.</p><p>Carnes D., Anwer Y., Underwood M. et al. Influences on older people's decision making regarding choice of topical or oral NSAIDs for knee pain: qulitative study. BMJ 2008; Jan 19; 336(7636): 142-5.</p><p>Patel R.K., Leswell P.F. Comparison of ketoprofen, piroxicam, and diclofenac gels in the treatment of acute soft-tissue injury in general practice. General Practice Study Group. Clin Ther 1996 May-Jun; 18(3): 497-507.</p><p>Kantor T.G. Ketoprofen: a review of its pharmacological and clinical properties. Pharmacotherapy 1986; 6(3).</p><p>Kubota T., Komatsu H., Kawamoto H. et al. Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis. Arch Int Pharmacodyn Ther 1979 Jan; 237(1): 169-76.</p><p>Guyonnet J.C., Julou L. Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents. Rheumatol Rehabil. 1976; suppl.: 11-4.</p><p>Чичасова Н.В. Локальная терапия хронических заболеваний опорно-двигательного аппарата. Спр поликл врача 2007; 4(6).</p></div><br />

The authors declare that there are no conflicts of interest present.