mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2025-5-7-12mrj-1834Research ArticleЛЕКЦИЯLECTUREЭпидемиология и генетика васкулитов крупных сосудов. Сообщение 1. Эпидемиологические и молекулярно-генетические аспекты артериита ТакаясуEpidemiology and genetics of large-vessel vasculitides. Report 1. Epidemiological and molecular genetic aspects of Takayasu arteritishttps://orcid.org/0000-0002-4906-7148ГусеваИ. А.GusevaI. A.

Ирина Анатольевна Гусева 

115522, Москва, Каширское шоссе, 34А 

Irina Anatolyevna Guseva 

34A, Kashirskoe Shosse, Moscow 115522 

irrgus@yandex.ruhttps://orcid.org/0000-0003-1880-5678БолотбековаА. М.BolotbekovaA. M.

720040, Бишкек, ул. Тоголока Молдо, 3

3, Togolok Moldo Street, Bishkek 720040 

https://orcid.org/0000-0002-4846-5531ЕгороваО. Н.EgorovaO. N.

115522, Москва, Каширское шоссе, 34А 

129110, Москва, ул. Щепкина, 61/2 

34A, Kashirskoe Shosse, Moscow 115522 

61/2, Schepkina Street, Moscow 129110 

https://orcid.org/0000-0001-9933-5350ТарасоваГ. М.TarasovaG. M.

115522, Москва, Каширское шоссе, 34А 

34A, Kashirskoe Shosse, Moscow 115522 

https://orcid.org/0000-0001-5433-3300КойлубаеваГ. М.KoylubaevaG. M.

720040, Бишкек, ул. Тоголока Молдо, 3

3, Togolok Moldo Street, Bishkek 720040 

https://orcid.org/0000-0002-6943-2915ЧанышевМ. Д.ChanyshevM. D.

111123, Москва, ул. Новогиреевская, 3А 

3A, Novogireevskaya Street, Moscow 111123 

https://orcid.org/0000-0001-7501-9185СамаркинаЕ. Ю.SamarkinaE. Yu.

115522, Москва, Каширское шоссе, 34А 

34A, Kashirskoe Shosse, Moscow 115522 

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationНациональный центр кардиологии и терапии им. акад. Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республикиКыргызстанNational Center of Cardiology and Therapy named after academician Mirsaid Mirrahimov, Ministry of Health of Kyrgyz RepublicKyrgyzstanФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» ; ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияV.A. Nasonova Research Institute of Rheumatology ; M.V. Vladimirsky Moscow Regional Research Clinical InstituteRussian FederationФБУН «Центральный научно-исследовательский институт эпидемиологии» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияCentral Research Institute of EpidemiologyRussian Federation202518102025195712Copyright © Гусева И.А., Болотбекова А.М., Егорова О.Н., Тарасова Г.М., Койлубаева Г.М., Чанышев М.Д., Самаркина Е.Ю., 20252025Гусева И.А., Болотбекова А.М., Егорова О.Н., Тарасова Г.М., Койлубаева Г.М., Чанышев М.Д., Самаркина Е.Ю.Guseva I.A., Bolotbekova A.M., Egorova O.N., Tarasova G.M., Koylubaeva G.M., Chanyshev M.D., Samarkina E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1834

Артериит Такаясу (АТ) – редкое системное заболевание, характеризующееся гранулематозным воспалением, которое поражает крупные артерии, преимущественно аорту и ее ветви. Впервые АТ был описан в Японии, где наблюдается его высокая распространенность, позднее немногочисленные случаи АТ были выявлены и в других этнических группах. Редкие случаи семейной агрегации заболевания позволили предположить вовлечение генетических факторов в патогенез АТ. Почти за 45-летнюю историю изучения генетики АТ не только установлена выраженная взаимосвязь заболевания с антигеном HLA-B5(52)/аллелем HLA-B*5201, но и определены другие HLA и не-HLA молекулярно-генетические маркеры.

Takayasu arteritis (TA) is a rare systemic disease characterized by granulomatous inflammation affecting large arteries, primarily the aorta and its branches. First described in Japan, where the disease has a high prevalence, TA was subsequently reported, though less frequently, in other ethnic groups. Rare cases of familial aggregation suggest the involvement of genetic factors in the pathogenesis of TA. During nearly 45 years of genetic research on TA, a strong association has been established with the HLA-B5(52) antigen/HLA-B*5201 allele, as well as with other HLA and non-HLA molecular genetic markers.

артериит ТакаясуэпидемиологияHLA-B52генетические полиморфизмыTakayasu arteritisepidemiologyHLA-B52genetic polymorphismsСтатья подготовлена в рамках научно-исследовательской работы (№/№ государственных заданий РК 122040400024-7) и международного сотрудничества ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» (Россия) и Национального центра кардиологии и терапии им. акад. Мирсаида Миррахимова при Министерстве здравоохранения Кыргызской республики (Кыргызстан).The article was prepared within the framework of the research project (State Assignment of the Russian Federation № PK-122040400024-7) and international cooperation between the V.A. 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The authors declare that there are no conflicts of interest present.