mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2008-500mrj-185Research ArticleСтатьиArticlesРоль герпес-вирусной инфекции при болезни (синдроме) ШегренаROLE OF HERPESVIRUS INFECTION IN SJЦ GREN'S DISEASEКозинаВ. И.KozinaV I-БалабановаРимма МихайловнаBalabanovaR M-ЕгороваО. Н.EgorovaO N-КосяковаН. П.KosyakovaN P-КозинаВ. И.KozinaV I-БалабановаРимма МихайловнаBalabanovaR M-YegorovaO NYegorovaO N-КосяковаН. П.KosyakovaN P-20080912200824№4 (2008)1114Copyright © Козина В.И., Балабанова Р.М., Егорова О.Н., Косякова Н.П., Козина В.И., Балабанова Р.М., Yegorova O.N., Косякова Н.П., 20082008Козина В.И., Балабанова Р.М., Егорова О.Н., Косякова Н.П., Козина В.И., Балабанова Р.М., Yegorova O.N., Косякова Н.П.Kozina V.I., Balabanova R.M., Egorova O.N., Kosyakova N.P., Kozina V.I., Balabanova R.M., Yegorova O.N., Kosyakova N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/185

Этиология болезни (синдрома) Шегрена (БШ,СШ) неизвестна, однако частое ее развитие у больных гепатитом В, С, СПИДом при инфицированности человеческим лимфотропным вирусом 1-го типа (HLTV 1) предполагает вирусную природу болезни. Многочисленные данные литературы свидетельствуют о перспективности изучения роли вирусной инфекции в развитии БШ и СШ, особенно на ранних стадиях заболевания.

The etiology of Sjц gren's disease (syndrome) - SD, SS - is unknown; however, its frequent development in patients with hepatitis B or C or AIDS in infection with human lymphotropic virus type (HLTV-1) suggests the viral nature of the disease. A large body of data available in the literature shows the promise of studying the implication of viral infection in the development of SD and SS, at the early stages of the development in particular.

References<div><p>Fox R.I. Sjц gren's syndrome. Controversies and progress. Clin Lab Med 1997; 17(3): 431-44.</p><p>Fox R.I., Tцrnwall J., Maruyama T. et al. Evolving concepts of diagnosis, pathogenesis, and therapy of Sjцgren's syndrome. Curr Opin Rheumatol 1998; 10(5): 446-56.</p><p>Васильев В.И. Болезнь Шегрена: клинико-лабораторные, иммуноморфологические проявления и прогноз. Дис. . д-ра. мед. наук М., 2007.</p><p>Fox R.I. Update in Sjц gren syndrome.Curr Opin Rheumatol 2000; 12(5): 391-8.</p><p>Moutsopouks H.M., Papadoрoulos G.K. Possible viral implication in the pathogenesis of Sjц gren syndrome. Eur JMed 1992; 1(4): 219-23.</p><p>Fujimuro M., Nakaso K., Nakashima K. et al. Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV. Exp Mol Pathol 2006; 80(2): 124-31.</p><p>Trimeche M., Ziadi S., Amara K. et al. Prevalence of Epstein-Barr virus in Sjц gren's syndrome in Tunisia. Rev Med Interne 2006; 27(7): 519-23.</p><p>Saito I., Nishimura S., Kudo I. et al. Detection of Epstein-Barr virus and human herpes virus type 6 in saliva from patients with lymphoproliferative diseases by the polymerase chain reaction. Arch Oral Biol 1991; 36(11): 779-84.</p><p>Deacon E.M., Matthews J.B., Potts A.J. et al. Detection of Epstein-Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjц gren's syndrome. J Pathol 1991; 163(4): 351-360.</p><p>He L.Y., Wang J.H., Wang S.W. Interrelationship between Epstein-Barr virus and Sjц gren's syndrome. Zhonghua Yi Xue Za Zhi 1994; 74(2): 97-9, 127-8.</p><p>Perrot S., Calvez V., Escande J.P. et al. Prevalences of herpesviruses DNA sequences in salivary gland biopsies from primary and secondary Sjц gren's syndrome using degenerated consensus PCR primers. J Clin Virol 2003; 28(2): 165-8.</p><p>Van Vooren J.P., Farber C.M., Daelemans P. et al. Acute Sjцgren-like syndrome as the first manifestation of a generalized CMV infection in a patient with AIDS. J Laryngol Otol 1995; 109(11): 1113-4.</p><p>Mariette X. Sjцgren's syndrome and virus. Rev Med Interne 1994; 15(9): 601-6.</p><p>Dawson T.M., Starkebaum G., Wood B.L. et al. Epstein-Barr virus, methotrexate, and lymphoma in patients with rheumatoid arthritis and primary Sjц gren's syndrome: case series. J Rheumatol 2001; 28(1): 47-53.</p><p>Ferraccioli G.F., Sorrentino D., De Vita S. et al. B cell clonality in gastric lymphoid tissues of patients with Sjц gren's syndrome. Ann Rheum Dis 1996; 55(5): 311-6.</p><p>Willoughby C.E., Baker K., Kaye S.B. et al. Epstein-Barr virus (types 1 and 2) in the tear film in Sjц gren's syndrome and HIV infection. J Med Virol 2002; 68(3): 378-83.</p><p>Venables P.J., Baboonian C., Horsfall A.C. et al. The response to Epstein-Barr virus infection in Sjц gren's syndrome. J Autoimmun 1989; 2(4): 439-48.</p><p>Newkirk M.M., Watanabe Duffy K.N., Leclerc J. et al. Detection of cytomegalovirus, Epstein-Barr virus and herpes virus-6 in patients with rheumatoid arthritis with or without Sjц gren's syndrome. Br J Rheumatol 1994; 33(4): 317-22.</p><p>Ranger-Rogez S., Vidal E., Labrousse F. et al. Large-scale study suggests no direct link between human herpesvirus-6 and primary Sjц gren's syndrome. J Med Virol 1995; 47(3):198-203.</p><p>Venables P.J., Ross M.G., Charles P.J. et al. A seroepidemio-logical study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome. Ann Rheum Dis 1985; 44(11): 742-6.</p><p>Origgi L., Hu C., Bertetti E. et al. Antibodies to Epstein-Barr virus and cytomegalovirus in primary Sjц gren's syndrome. Boll Ist Sieroter Milan 1988; 67(4): 265-74.</p><p>Shillitoe E.J., Daniels T.E., Whitcher J.P. et al. Antibody to cytomegalovirus in patients with Sjц gren's syndrome. As determined by an enzyme-linked immunosorbent assay. Arthritis Rheum 1982; 25(3): 260-5.</p><p>Thorn J.J., Oxholm P., Andersen H.K. High levels of complement fixing antibodies against cytomegalovirus in patients with primary Sjц gren's syndrome. Clin Exp Rheumatol 1988; 6(1): 71-4.</p></div><br /><div><p>Fox R.I. Sjц gren's syndrome. Controversies and progress. Clin Lab Med 1997; 17(3): 431-44.</p><p>Fox R.I., Tцrnwall J., Maruyama T. et al. Evolving concepts of diagnosis, pathogenesis, and therapy of Sjцgren's syndrome. Curr Opin Rheumatol 1998; 10(5): 446-56.</p><p>Васильев В.И. Болезнь Шегрена: клинико-лабораторные, иммуноморфологические проявления и прогноз. Дис. . д-ра. мед. наук М., 2007.</p><p>Fox R.I. Update in Sjц gren syndrome.Curr Opin Rheumatol 2000; 12(5): 391-8.</p><p>Moutsopouks H.M., Papadoрoulos G.K. Possible viral implication in the pathogenesis of Sjц gren syndrome. Eur JMed 1992; 1(4): 219-23.</p><p>Fujimuro M., Nakaso K., Nakashima K. et al. Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV. Exp Mol Pathol 2006; 80(2): 124-31.</p><p>Trimeche M., Ziadi S., Amara K. et al. Prevalence of Epstein-Barr virus in Sjц gren's syndrome in Tunisia. Rev Med Interne 2006; 27(7): 519-23.</p><p>Saito I., Nishimura S., Kudo I. et al. Detection of Epstein-Barr virus and human herpes virus type 6 in saliva from patients with lymphoproliferative diseases by the polymerase chain reaction. Arch Oral Biol 1991; 36(11): 779-84.</p><p>Deacon E.M., Matthews J.B., Potts A.J. et al. Detection of Epstein-Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjц gren's syndrome. J Pathol 1991; 163(4): 351-360.</p><p>He L.Y., Wang J.H., Wang S.W. Interrelationship between Epstein-Barr virus and Sjц gren's syndrome. Zhonghua Yi Xue Za Zhi 1994; 74(2): 97-9, 127-8.</p><p>Perrot S., Calvez V., Escande J.P. et al. Prevalences of herpesviruses DNA sequences in salivary gland biopsies from primary and secondary Sjц gren's syndrome using degenerated consensus PCR primers. J Clin Virol 2003; 28(2): 165-8.</p><p>Van Vooren J.P., Farber C.M., Daelemans P. et al. Acute Sjцgren-like syndrome as the first manifestation of a generalized CMV infection in a patient with AIDS. J Laryngol Otol 1995; 109(11): 1113-4.</p><p>Mariette X. Sjцgren's syndrome and virus. Rev Med Interne 1994; 15(9): 601-6.</p><p>Dawson T.M., Starkebaum G., Wood B.L. et al. Epstein-Barr virus, methotrexate, and lymphoma in patients with rheumatoid arthritis and primary Sjц gren's syndrome: case series. J Rheumatol 2001; 28(1): 47-53.</p><p>Ferraccioli G.F., Sorrentino D., De Vita S. et al. B cell clonality in gastric lymphoid tissues of patients with Sjц gren's syndrome. Ann Rheum Dis 1996; 55(5): 311-6.</p><p>Willoughby C.E., Baker K., Kaye S.B. et al. Epstein-Barr virus (types 1 and 2) in the tear film in Sjц gren's syndrome and HIV infection. J Med Virol 2002; 68(3): 378-83.</p><p>Venables P.J., Baboonian C., Horsfall A.C. et al. The response to Epstein-Barr virus infection in Sjц gren's syndrome. J Autoimmun 1989; 2(4): 439-48.</p><p>Newkirk M.M., Watanabe Duffy K.N., Leclerc J. et al. Detection of cytomegalovirus, Epstein-Barr virus and herpes virus-6 in patients with rheumatoid arthritis with or without Sjц gren's syndrome. Br J Rheumatol 1994; 33(4): 317-22.</p><p>Ranger-Rogez S., Vidal E., Labrousse F. et al. Large-scale study suggests no direct link between human herpesvirus-6 and primary Sjц gren's syndrome. J Med Virol 1995; 47(3):198-203.</p><p>Venables P.J., Ross M.G., Charles P.J. et al. A seroepidemio-logical study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome. Ann Rheum Dis 1985; 44(11): 742-6.</p><p>Origgi L., Hu C., Bertetti E. et al. Antibodies to Epstein-Barr virus and cytomegalovirus in primary Sjц gren's syndrome. Boll Ist Sieroter Milan 1988; 67(4): 265-74.</p><p>Shillitoe E.J., Daniels T.E., Whitcher J.P. et al. Antibody to cytomegalovirus in patients with Sjц gren's syndrome. As determined by an enzyme-linked immunosorbent assay. Arthritis Rheum 1982; 25(3): 260-5.</p><p>Thorn J.J., Oxholm P., Andersen H.K. High levels of complement fixing antibodies against cytomegalovirus in patients with primary Sjц gren's syndrome. Clin Exp Rheumatol 1988; 6(1): 71-4.</p></div><br />

The authors declare that there are no conflicts of interest present.