mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2025-6-42-47mrj-1877Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSМикроархитектоника костной ткани при ревматоидном артрите: фокус на трабекулярный костный индексBone microarchitecture in rheumatoid arthritis: focus on trabecular bone indexhttps://orcid.org/0000-0003-0560-3495КозыреваМ. В.KozyrevaM. V.

Мария Витальевна Козырева

115522, Москва, Каширское шоссе, 34А

Maria Vitalyevna Kozyreva

34A, Kashirskoe Shosse, Moscow 115522

doginya@yandex.ruhttps://orcid.org/0000-0001-6759-8367НикитинскаяО. А.NikitinskayaO. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0003-0961-9785ДеминН. В.DeminN. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation2025221220251964247Copyright © Козырева М.В., Никитинская О.А., Демин Н.В., Торопцова Н.В., 20252025Козырева М.В., Никитинская О.А., Демин Н.В., Торопцова Н.В.Kozyreva M.V., Nikitinskaya O.A., Demin N.V., Toroptsova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1877

Цель исследования – изучить показатели активности воспаления и биохимические маркеры костного обмена как факторы, влияющие на микроархитектонику кости, оцененную по трабекулярному костному индексу (ТКИ), у женщин с ревматоидным артритом (РА).

Материал и методы

Материал и методы. В одномоментном исследовании участвовали 124 женщины с достоверным РА (средний возраст – 60,3±10,0 лет). Проведены анкетирование по разработанному опроснику, лабораторное обследование, рентгеновская денситометрия поясничного отдела позвоночника (LI–IV) с определением ТКИ.

Результаты и обсуждение

Результаты и обсуждение. Деградированная микроархитектоника костной ткани выявлена у 33,9%, частично деградированная – у 21,8%, нормальная – у 44,3% женщин с РА. В однофакторном регрессионном анализе возраст (p<0,001), длительность постменопаузы (p=0,035), уровни мочевой кислоты (МК; p=0,023), щелочной фосфатазы (ЩФ; p=0,021), антител к циклическому цитруллинированному пептиду (АЦЦП; p=0,037) и фосфора (=0,23; p=0,011) коррелировали со значением ТКИ.

Заключение

Заключение. Нормальная микроархитектоника выявлена лишь у 44,3% женщин с РА. ТКИ негативно взаимосвязан с возрастом, длительностью постменопаузы, уровнем МК, ЩФ и АЦЦП и позитивно – с уровнем фосфора. Не наблюдалось корреляции между значением ТКИ и показателями воспалительной активности РА.

Objective

Objective: to investigate indicators of inflammatory activity and biochemical markers of bone metabolism as factors influencing bone microarchitecture, assessed by the trabecular bone index (TBI), in women with rheumatoid arthritis (RA).

Material and methods

Material and methods. A cross-sectional study included 124 women with verified RA (mean age 60.3±10.0 years). A survey using a proprietary questionnaire, laboratory testing, and lumbar spine (L1–IV) X-ray densitometry with determination of TBI were performed.

Results and discussion

Results and discussion. Degraded bone microarchitecture was found in 33.9%, partially degraded in 21.8%, and normal in 44.3% of women with RA. In univariate regression analysis, age (p<0.001), duration of postmenopause (p=0.035), levels of uric acid (UA; p=0.023), alkaline phosphatase (ALP; p=0.021), anti-cyclic citrullinated peptide antibodies (anti-CCP; p=0.037), and phosphorus (=0.23; p=0.011) correlated with TBI values.

Conclusion

Conclusion. Normal bone microarchitecture was found in only 44.3% of women with RA. TBI was negatively associated with age, duration of postmenopause, levels of UA, ALP, and anti-CCP, and positively with phosphorus level. No correlation was observed between TBI values and indicators of RA inflammatory activity.

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The authors declare that there are no conflicts of interest present.