mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2026-2-21-28mrj-1953Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL GUIDELINESОбновленные международные рекомендации (EULAR 2023) по лечению системной склеродермииUpdated international recommendations (EULAR 2023) for the treatment of systemic sclerosishttps://orcid.org/0000-0001-5926-7912ТрофимоваА. С.TrofimovaA. S.

Анна Сергеевна Трофимова 

195015, Санкт-Петербург, ул. Кирочная, 41 

Anna Sergeevna Trofimova 

41, Kirochnaya Street, Saint Petersburg 195015 

anna.trofimova@szgmu.ruhttps://orcid.org/0000-0002-0797-2051МазуровВ. И.MazurovV. I.

195015, Санкт-Петербург, ул. Кирочная, 41 

41, Kirochnaya Street, Saint Petersburg 195015 

https://orcid.org/0000-0002-7590-742XМячиковаВ. Ю.MyachikovaV. Yu.

197341, Санкт-Петербург, ул. Аккуратова, 2 

2, Akkuratova Street, Saint Petersburg 197341 

https://orcid.org/0000-0001-8598-0391КувардинЕ. С.KuvardinE. S.

197341, Санкт-Петербург, ул. Аккуратова, 2 

2, Akkuratova Street, Saint Petersburg 197341 

https://orcid.org/0000-0003-2427-4148МаслянскийА. Л.MaslyanskiyA. L.

197341, Санкт-Петербург, ул. Аккуратова, 2 

115522, Москва, Каширское шоссе, 34А 

2, Akkuratova Street, Saint Petersburg 197341 

34A, Kashirskoe Shosse, Moscow 115522 

https://orcid.org/0000-0003-3236-4485ТрофимовЕ. А.TrofimovE. A.

195015, Санкт-Петербург, ул. Кирочная, 41 

41, Kirochnaya Street, Saint Petersburg 195015 

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University named after I.I. Mechnikov, Ministry of Health of RussiaRussian FederationФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииРоссияV.A. Almazov National Medical Research Center, Ministry of Health of RussiaRussian FederationФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России ; ФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Almazov National Medical Research Center, Ministry of Health of Russia ; V.A. Nasonova Research Institute of RheumatologyRussian Federation2026220420262022128Copyright © Трофимова А.С., Мазуров В.И., Мячикова В.Ю., Кувардин Е.С., Маслянский А.Л., Трофимов Е.А., 20262026Трофимова А.С., Мазуров В.И., Мячикова В.Ю., Кувардин Е.С., Маслянский А.Л., Трофимов Е.А.Trofimova A.S., Mazurov V.I., Myachikova V.Y., Kuvardin E.S., Maslyanskiy A.L., Trofimov E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/1953

В последние годы наблюдается значительный прогресс в изучении системной склеродермии (ССД). Для лечения ССД применяются традиционные синтетические базисные противовоспалительные препараты, генно-инженерные биологические препараты, включая анти-В-клеточные препараты и ингибиторы интерлейкина 6, а также антифиброзные средства. Со времени последней публикации рекомендаций EULAR по лечению ССД в 2017 г. произошли изменения, поэтому было подготовлено их обновление, в котором более широко рассматривается лечение всего спектра проявлений ССД, сформулировано 22 рекомендации и выделено 8 терапевтических доменов. В статье представлены рекомендации EULAR 2023 г. по лечению ССД, а также перспективные направления научных исследований.

In recent years, significant progress has been achieved in the study of systemic sclerosis (SSc). The treatment of SSc includes conventional synthetic disease-modifying antirheumatic drugs, biologic agents, including anti-B-cell drugs and interleukin-6 inhibitors, as well as antifibrotic agents. Since the last publication of the EULAR recommendations for the treatment of SSc in 2017, changes have occurred; therefore, an update was prepared in which the treatment of the full spectrum of SSc manifestations is considered more broadly. In the updated document 22 recommendations were formulated, and 8 therapeutic domains were identified. The article presents the EULAR 2023 recommendations for the treatment of SSc, as well as promising directions for scientific research.

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The authors declare that there are no conflicts of interest present.