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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2009-576</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-261</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Фармакотерапия ревматоидного артрита в XXI веке: фокус на ритуксимаб</article-title><trans-title-group xml:lang="en"><trans-title>PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS IN THE 21st CENTURY: FOCUS ON RITUXIMAB</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Евгений Львович</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>Evgeni Lvovich</given-names></name></name-alternatives><email xlink:type="simple">nasonov@irramn.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2009</year></pub-date><volume>3</volume><issue>4</issue><issue-title>№4 (2009)</issue-title><fpage>67</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Насонов Е.Л., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Насонов Е.Л.</copyright-holder><copyright-holder xml:lang="en">Nasonov E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/261">https://mrj.ima-press.net/mrj/article/view/261</self-uri><abstract><p>Ревматоидный артрит (РА) относится к числу наиболее распространенных и тяжелых хронических воспалительных заболеваний. Представлен обзор современных исследований, посвященных оценке эффективности препарата ритуксимаб (Мабтера®) - химерных моноклональных антител к CD20 молекуле В-клеток - у больных РА. Показано, что ритуксимаб является чрезвычайно эффективным и относительно безопасным препаратом для лечения РА и может рассматриваться как прообраз нового направления в лечении аутоиммунных заболеваний, в основе которого лежит модуляция В-клеточного звена иммунитета</p></abstract><trans-abstract xml:lang="en"><p>Rheumatoid arthritis (RA) is one of the most common and severe chronic inflammatory diseases. The paper reviews the recent studies evaluating the efficacy of rituximab (MabThera®), chimeric anti-CD20 monoclonal antibodies in B cells, in patients with RA. It has been shown that Rituximab is an extremely effective and relatively safe drug for the treatment of RA and may be considered to be a prototype for a new line in the management of autoimmune diseases, the basis for which is B-cell immunity modulation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>базисные противовоспалительные препараты</kwd><kwd>ингибиторы фактора некроза опухоли а</kwd><kwd>ритуксимаб</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
