mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2011-693mrj-378Research ArticleСтатьиArticlesСистемная красная волчанка: многообразие форм и вариантов теченияSistemnaya krasnaya volchanka: mnogoobrazie form i variantov techeniyaКлюквинаН. Г.KlyukvinaNatalia Gennadyevnanataklykvina@yandex.ru <mailto:nataklykvina@yandex.ru>20111712201154№4 (2011)2530Copyright © Клюквина Н.Г., 20112011Клюквина Н.Г.Klyukvina N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/378системная красная волчанкакритерии диагнозаварианты теченияисходыsystemic lupus erythematosusdiagnostic criteriatypes of a courseoutcomes.References<div><p>Uramoto K.M., Michet C.J., Thumbo J. et al. Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992. Arthr Rheum 1999;42:46-50.</p><p>Ansar A.S., Penhale W.I., Talal N. Sex hormones, immune response, and autoimmune diseases/ Mechanisms of sex hormone action. Am J Pathol 1985;121:531-51.</p><p>Lockshin M.D. Sex differences in autoimmune disease. Lupus 2006;15:753-6.</p><p>Jonsson J., Nived O., Stufelt G. Outcome in systemic lupus erythematosus: a prospective study of patients from a defined population. Medicine 1989;68:141-50</p><p>Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthr Rheum 1997;40:1725-9.</p><p>Lupus: A GP Guide to diagnosis. Complied by Y. Norton. Lupus UK. 2000;3-6.</p><p>Иванова М.М. Системная красная волчанка. В кн.: Диффузные болезни соединительной ткани. М.: Медицина, 1994;231-301.</p><p>Dubois's lupus erythematosus. 6th ed. Wallace D.J., Hahn B.H. (eds). Rhiladelphia, PA: Lippincott Williams & Wilkins, 2001</p><p>Costallat L.T.L., Coimbra A.M.V. Systemic lupus erythematosus: clinical and laboratory aspects related to age at disease onset. Clin 7. ОБЗОР Experim Rheum 1994;12:603-7.</p><p>Tucker L.B. Making the diagnosis of systemic lupus erythematosus in children and adolescents. Lupus 2007;16:546-9.</p><p>Font J., Cervera R., Espinosa G. et al. Systemic lupus erythematosus in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 1998;57:456-9</p><p>Tucker L.B., Menon S., Schaller J.G. Adult- and childhood onset systemic lupus erythematosus: a comparison of onset, clinical features, serology and outcome. Br J Rheum 1995;34(9):866-72.</p><p>Marini R., Costallat L.T. Young age at onset, renal involvement and arterial hypertension are adverse prognostic significance in juvenile systemic lupus erythematosus. - Review of Rheumatology of Engl. Education. 1999;66(6):303-9.</p><p>Иванова М.М. Прогноз заболевания и особенности лечения больных системной красной волчанкой в различных возрастных группах. Тер арх 1985;6:125-8.</p><p>Насонова В.А., Фоломеева О.М. Системная красная волчанка у подростков. Клин мед 1986;1:30-8.</p><p>Bresnihan B. Outcome and survival in systemic lupus erythematosus. Ann Rheum Dis 1989;48:443-5.</p><p>Балабан С.Я., Петрова В.И. Особенности течения системной красной волчанки у больных среднего и пожилого возраста. Ревматология 1985;1:30-2.</p><p>Bertolli A.M., Alarcon G.S., Calvo-Alen J. et al. Systemic lupus erythematosus in a multiethnic US cohort. Clinical features, course and outcome in patients with late-onset disease. Arthr Rheum 2006;54(5):1580-7.</p><p>Ward M.M., Pyun E., Studenski S. Long-term survival in systemic lupus erythematosus. Patients characteristics associated with poorer outcomes. Arthr Rheum 1995;38(2):274-83.</p><p>Pu S.I., Luo S.F., Wu Y.J. et al. The clinical fearutes and prognosis of lupus with disease onset at age 65 and older. Lupus 2000;9:95-100.</p><p>Garcia M.A., Marcos J.C., Marcos A.I. et al. Male systemic lupus erythematosus in a Latin-American inception cohort of 1214 patients. Lupus 2005;14:938-46.</p><p>Voulgari P.V., Katsimbri P., Alamanos Y. et al. Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature. Lupus 2002;11:722-9.</p><p>Клюквина Н.Г., Ильина А.Е. Системная красная волчанка у мужчин. РМЖ 2005;13(8):513-8.</p><p>Ward M.M., Studenski S. Systemic lupus erythematosus in men: multivariate analysis of gender differences in clinical manifestations. J. Rheum 1990;17(2):222-4.</p><p>Ильина А.Е., Клюквина Н.Г., Александрова Е.Н. и др. Атеросклеротическое поражение сосудов при системной красной волчанке и антифосфолипидном синдроме у мужчин. Науч-практич ревматол 2005;5:4-10.</p><p>Wallace D.J., Podell T., Weiner J. et al. Systemic lupus erythematosus survival patterns: experience with 609 patients. J Am Med Assoc 1981;245:934-8.</p><p>Andrade R.M., Alarcon G.S., Fernandez M. et al. Accelerated damage accrual among men with systemic lupus erythematosus. XLIY. Results from a multiethnic US cohort. Arthr Rheum 2007;56(2):622-30.</p><p>Chlebus E., Wolska H., Blaszczyk M. et al. Subacute cutaneous lupus erythematosus versus systemic lupus erythematosus: diagnostic criteria and theraupetic implications. J Am Acad Dermat 1998;38:405-12.</p><p>Насонов Е.Л. Антифосфолипидный синдром. М.: Литтерра, 2004;440 с.</p><p>Cervera R., Piette J.C., Font I. et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthr Rheum 2002;46:1019-25.</p><p>Решетняк Т.М., Середавкина Н.В., Насонов Е.Л. Кардиоваскулярные аспекты антифосфолипидного синдрома. Клин мед 2008;9:4-12</p><p>Neonatal lupus erythematosus. In: Hurwitz S. Clinical pediatric dermatology: a textbook of skin disorders of childhood and adolescence.2nd ed. Philadelphia: WB.Saunders, 1993;567-9.</p><p>Watson R.M., Lane A.T., Barmett N.K. et al. Neonatal lupus erythematosus. A clinical, serological and immunogenetic study with review of the literature. Medicine 1984;63:362-78.</p><p>McKinlay J.R., Cooke L., Cunningham B.B. et al. Neonatal lupus erythematosus. J Am Board Fam Pract 2001;14(1):68-70.</p><p>Lau C.S., Yin G., Mok M.Y. Ethnic and geographical differences in systemic lupus erythematosus: an overview. Lupus 2006;15:715-9</p><p>Liang M.H., Partidge A.J., Daltroy L.H. et al. Strategies for reducing excess morbidity and mortality in blacks with systemic lupus erythematosus. Arthr Rheum 1991;34:1187-96</p><p>Sule S., Petri M. Socioecnomic status in systemic lupus erythematosus. Lupus 2006;15:720-3. Ward M.M. Education level and mortality in systemic lupus erythematosus: evidence of underascertainment of death due to SLE in ethnic minorities with low education levels. Arthr Rheum 2005;51:616-24</p><p>Alarcon G.S., McGwin G.J., Sanchez M.L. et al. Systemic lupus erythematosus in three ethnic groups. XIY. Poverty, wealth, and their influence on disease activity. Arthr Rheum 2004;51:73-7.</p><p>Ehrenstein M.R., Conroy S.E., Heath J. et al. The occurrence, nature and distribution of flares in a cohort of patients with systemic lupus erythematosus: a rheumatological view. Brit J Rheum 1995;34:257-60.</p><p>Swaak A.J.G., van den Brink H.G., Smeenk R.J.T. et al. Systemic lupus erythematosus: clinical features in patients with disease duration of over 10 years, first evaluation. J Rheum 1999;38:953-8.</p><p>Swaak A.J.G., van den Brink H.G., Smeenk R.J.T. et al. Systemic lupus erythemanosus. Disease outcome in patients with a disease duration of at least 10 years: second evaluation. Lupus 2001;10:51-8.</p><p>Laustrup H., Voss A., Green A. et al. SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study Lupus 2010;19:239-46. Petri M., Buyon J., Kim M. Classification and definition of major flares in SLE clinical trialsio. Lupus 1999;8:685-91</p><p>Bresnihan B. Outcome and survival in systemic lupus erythematosus. Ann Rheum Dis 1989;48:443-5</p><p>Bertsias G., Ioannidis J.P., Boletis J. et al. EULAR recommendations for the management of systemic lupus erythematosus. Report of a task force of the EULAR Standing Committee for International Clinical Studies including therapeutics. Ann Rheum Dis 2008;67:195-205.</p><p>Petri M., Barr S.G., Zonana-Nach A. et al. Measures of disease activity, damage and health status. The Hopkins Lupus Cohort Experience. J Rheum 1999;26:502-3</p><p>Gladman D.D., Urowitz M.B., Rahman P. et al. Accrural of organ damage over time in patients with systemic lupus erythematosus. J Rheum 2003;30:1955-9.</p><p>Rahman P., Gladman D.D., Urowitz M.B. et al. Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus. Lupus 2001;10:93-6.</p><p>Merrell M., Shulman L.E. Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus. J Chron Dis 1955;1:12-32.</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. et al. Mortality studies in systemic lupus erythematosus: results from a single center. I. Causes of death. J Rheum 1995;22:1259-64.</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. et al. Mortality studies in systemic lupus erythematosus: results from a single center.2. Predictor variables for mortality. J Rheum 1995;22:1265-70.</p><p>Ward M.M., Pyun E., Studenski S. Mortality risks associated with specific clinical manifestations of systemic lupus erythematosus. Arch Intern Med 1996;156:1337-44</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. Improved survival in cohort of SLE patients compared to the general population over a 25-year period of observation. Lupus 1995;4(2):15.</p><p>Nived O., Sturfelt G. Mortality in systemic lupus erythematosus. Rheum Eur 1996;25(1):17-9.</p><p>Alarcon-Segovia D. Treatment needed to achieve remission of SLE. Lupus 1999;8:566.</p><p>Drencard C., Villa A.R., Garcia-Padilla C. et al. Remission of systemic lupus erythematosus. Medicine (Baltimore) 1996;75:88-98.</p><p>Remission, relapse and re-remission of proliferative lupus nephritis treated with cyclophosphamide. Kidney Intern 2000;57(1):258-64.</p><p>Иванова М.М. Эволюция методов лечения системной красной волчанки. Избранные лекции по клинической ревматологии. Под ред. В.А. Насоновой, Н.В. Бунчука. М.: Медицина, 2001;79-83</p></div><br /><div><p>Uramoto K.M., Michet C.J., Thumbo J. et al. Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992. Arthr Rheum 1999;42:46-50.</p><p>Ansar A.S., Penhale W.I., Talal N. Sex hormones, immune response, and autoimmune diseases/ Mechanisms of sex hormone action. Am J Pathol 1985;121:531-51.</p><p>Lockshin M.D. Sex differences in autoimmune disease. Lupus 2006;15:753-6.</p><p>Jonsson J., Nived O., Stufelt G. Outcome in systemic lupus erythematosus: a prospective study of patients from a defined population. Medicine 1989;68:141-50</p><p>Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthr Rheum 1997;40:1725-9.</p><p>Lupus: A GP Guide to diagnosis. Complied by Y. Norton. Lupus UK. 2000;3-6.</p><p>Иванова М.М. Системная красная волчанка. В кн.: Диффузные болезни соединительной ткани. М.: Медицина, 1994;231-301.</p><p>Dubois's lupus erythematosus. 6th ed. Wallace D.J., Hahn B.H. (eds). Rhiladelphia, PA: Lippincott Williams & Wilkins, 2001</p><p>Costallat L.T.L., Coimbra A.M.V. Systemic lupus erythematosus: clinical and laboratory aspects related to age at disease onset. Clin 7. ОБЗОР Experim Rheum 1994;12:603-7.</p><p>Tucker L.B. Making the diagnosis of systemic lupus erythematosus in children and adolescents. Lupus 2007;16:546-9.</p><p>Font J., Cervera R., Espinosa G. et al. Systemic lupus erythematosus in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 1998;57:456-9</p><p>Tucker L.B., Menon S., Schaller J.G. Adult- and childhood onset systemic lupus erythematosus: a comparison of onset, clinical features, serology and outcome. Br J Rheum 1995;34(9):866-72.</p><p>Marini R., Costallat L.T. Young age at onset, renal involvement and arterial hypertension are adverse prognostic significance in juvenile systemic lupus erythematosus. - Review of Rheumatology of Engl. Education. 1999;66(6):303-9.</p><p>Иванова М.М. Прогноз заболевания и особенности лечения больных системной красной волчанкой в различных возрастных группах. Тер арх 1985;6:125-8.</p><p>Насонова В.А., Фоломеева О.М. Системная красная волчанка у подростков. Клин мед 1986;1:30-8.</p><p>Bresnihan B. Outcome and survival in systemic lupus erythematosus. Ann Rheum Dis 1989;48:443-5.</p><p>Балабан С.Я., Петрова В.И. Особенности течения системной красной волчанки у больных среднего и пожилого возраста. Ревматология 1985;1:30-2.</p><p>Bertolli A.M., Alarcon G.S., Calvo-Alen J. et al. Systemic lupus erythematosus in a multiethnic US cohort. Clinical features, course and outcome in patients with late-onset disease. Arthr Rheum 2006;54(5):1580-7.</p><p>Ward M.M., Pyun E., Studenski S. Long-term survival in systemic lupus erythematosus. Patients characteristics associated with poorer outcomes. Arthr Rheum 1995;38(2):274-83.</p><p>Pu S.I., Luo S.F., Wu Y.J. et al. The clinical fearutes and prognosis of lupus with disease onset at age 65 and older. Lupus 2000;9:95-100.</p><p>Garcia M.A., Marcos J.C., Marcos A.I. et al. Male systemic lupus erythematosus in a Latin-American inception cohort of 1214 patients. Lupus 2005;14:938-46.</p><p>Voulgari P.V., Katsimbri P., Alamanos Y. et al. Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature. Lupus 2002;11:722-9.</p><p>Клюквина Н.Г., Ильина А.Е. Системная красная волчанка у мужчин. РМЖ 2005;13(8):513-8.</p><p>Ward M.M., Studenski S. Systemic lupus erythematosus in men: multivariate analysis of gender differences in clinical manifestations. J. Rheum 1990;17(2):222-4.</p><p>Ильина А.Е., Клюквина Н.Г., Александрова Е.Н. и др. Атеросклеротическое поражение сосудов при системной красной волчанке и антифосфолипидном синдроме у мужчин. Науч-практич ревматол 2005;5:4-10.</p><p>Wallace D.J., Podell T., Weiner J. et al. Systemic lupus erythematosus survival patterns: experience with 609 patients. J Am Med Assoc 1981;245:934-8.</p><p>Andrade R.M., Alarcon G.S., Fernandez M. et al. Accelerated damage accrual among men with systemic lupus erythematosus. XLIY. Results from a multiethnic US cohort. Arthr Rheum 2007;56(2):622-30.</p><p>Chlebus E., Wolska H., Blaszczyk M. et al. Subacute cutaneous lupus erythematosus versus systemic lupus erythematosus: diagnostic criteria and theraupetic implications. J Am Acad Dermat 1998;38:405-12.</p><p>Насонов Е.Л. Антифосфолипидный синдром. М.: Литтерра, 2004;440 с.</p><p>Cervera R., Piette J.C., Font I. et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthr Rheum 2002;46:1019-25.</p><p>Решетняк Т.М., Середавкина Н.В., Насонов Е.Л. Кардиоваскулярные аспекты антифосфолипидного синдрома. Клин мед 2008;9:4-12</p><p>Neonatal lupus erythematosus. In: Hurwitz S. Clinical pediatric dermatology: a textbook of skin disorders of childhood and adolescence.2nd ed. Philadelphia: WB.Saunders, 1993;567-9.</p><p>Watson R.M., Lane A.T., Barmett N.K. et al. Neonatal lupus erythematosus. A clinical, serological and immunogenetic study with review of the literature. Medicine 1984;63:362-78.</p><p>McKinlay J.R., Cooke L., Cunningham B.B. et al. Neonatal lupus erythematosus. J Am Board Fam Pract 2001;14(1):68-70.</p><p>Lau C.S., Yin G., Mok M.Y. Ethnic and geographical differences in systemic lupus erythematosus: an overview. Lupus 2006;15:715-9</p><p>Liang M.H., Partidge A.J., Daltroy L.H. et al. Strategies for reducing excess morbidity and mortality in blacks with systemic lupus erythematosus. Arthr Rheum 1991;34:1187-96</p><p>Sule S., Petri M. Socioecnomic status in systemic lupus erythematosus. Lupus 2006;15:720-3. Ward M.M. Education level and mortality in systemic lupus erythematosus: evidence of underascertainment of death due to SLE in ethnic minorities with low education levels. Arthr Rheum 2005;51:616-24</p><p>Alarcon G.S., McGwin G.J., Sanchez M.L. et al. Systemic lupus erythematosus in three ethnic groups. XIY. Poverty, wealth, and their influence on disease activity. Arthr Rheum 2004;51:73-7.</p><p>Ehrenstein M.R., Conroy S.E., Heath J. et al. The occurrence, nature and distribution of flares in a cohort of patients with systemic lupus erythematosus: a rheumatological view. Brit J Rheum 1995;34:257-60.</p><p>Swaak A.J.G., van den Brink H.G., Smeenk R.J.T. et al. Systemic lupus erythematosus: clinical features in patients with disease duration of over 10 years, first evaluation. J Rheum 1999;38:953-8.</p><p>Swaak A.J.G., van den Brink H.G., Smeenk R.J.T. et al. Systemic lupus erythemanosus. Disease outcome in patients with a disease duration of at least 10 years: second evaluation. Lupus 2001;10:51-8.</p><p>Laustrup H., Voss A., Green A. et al. SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study Lupus 2010;19:239-46. Petri M., Buyon J., Kim M. Classification and definition of major flares in SLE clinical trialsio. Lupus 1999;8:685-91</p><p>Bresnihan B. Outcome and survival in systemic lupus erythematosus. Ann Rheum Dis 1989;48:443-5</p><p>Bertsias G., Ioannidis J.P., Boletis J. et al. EULAR recommendations for the management of systemic lupus erythematosus. Report of a task force of the EULAR Standing Committee for International Clinical Studies including therapeutics. Ann Rheum Dis 2008;67:195-205.</p><p>Petri M., Barr S.G., Zonana-Nach A. et al. Measures of disease activity, damage and health status. The Hopkins Lupus Cohort Experience. J Rheum 1999;26:502-3</p><p>Gladman D.D., Urowitz M.B., Rahman P. et al. Accrural of organ damage over time in patients with systemic lupus erythematosus. J Rheum 2003;30:1955-9.</p><p>Rahman P., Gladman D.D., Urowitz M.B. et al. Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus. Lupus 2001;10:93-6.</p><p>Merrell M., Shulman L.E. Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus. J Chron Dis 1955;1:12-32.</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. et al. Mortality studies in systemic lupus erythematosus: results from a single center. I. Causes of death. J Rheum 1995;22:1259-64.</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. et al. Mortality studies in systemic lupus erythematosus: results from a single center.2. Predictor variables for mortality. J Rheum 1995;22:1265-70.</p><p>Ward M.M., Pyun E., Studenski S. Mortality risks associated with specific clinical manifestations of systemic lupus erythematosus. Arch Intern Med 1996;156:1337-44</p><p>Abu-Shakra M., Urowitz M.B., Gladman D.D. Improved survival in cohort of SLE patients compared to the general population over a 25-year period of observation. Lupus 1995;4(2):15.</p><p>Nived O., Sturfelt G. Mortality in systemic lupus erythematosus. Rheum Eur 1996;25(1):17-9.</p><p>Alarcon-Segovia D. Treatment needed to achieve remission of SLE. Lupus 1999;8:566.</p><p>Drencard C., Villa A.R., Garcia-Padilla C. et al. Remission of systemic lupus erythematosus. Medicine (Baltimore) 1996;75:88-98.</p><p>Remission, relapse and re-remission of proliferative lupus nephritis treated with cyclophosphamide. Kidney Intern 2000;57(1):258-64.</p><p>Иванова М.М. Эволюция методов лечения системной красной волчанки. Избранные лекции по клинической ревматологии. Под ред. В.А. Насоновой, Н.В. Бунчука. М.: Медицина, 2001;79-83</p></div><br />
The authors declare that there are no conflicts of interest present.