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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2013-2388</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-486</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Остеоартроз: старая болезнь, новые подходы</article-title><trans-title-group xml:lang="en"><trans-title>Osteoarthrosis: An old disease, novel approaches</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубиков</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubikov</surname><given-names>Aleksandr Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">dottore@vladivostok.com</email></contrib></contrib-group><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2013</year></pub-date><volume>7</volume><issue>2</issue><issue-title>№2 (2013)</issue-title><fpage>82</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дубиков А.И., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Дубиков А.И.</copyright-holder><copyright-holder xml:lang="en">Dubikov A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/486">https://mrj.ima-press.net/mrj/article/view/486</self-uri><abstract><p>Остеоартроз (ОА) — одно из самых распространенных заболеваний пожилого возраста, тем не менее его лечение требует дальнейшего изучения. Современные представления о патофизиологии ОА, роли субхондральной кости (СК), взаимодействии СК и суставного хряща в процессе развития заболевания меняются. Данные последних исследований позволяют говорить о новых терапевтических стратегиях, одной из которых является применение стронция ранелата с целью замедления прогрессирования разрушения хряща при ОА коленного и тазобедренного суставов.</p></abstract><trans-abstract xml:lang="en"><p>Osteoarthrosis (OA) is one of the most common diseases in the elderly; nonetheless, its treatment calls for further investigation. Present views are changing on the pathophysiology of OA, the role of the subchondral bone (SB), and an interaction between SB and articular cartilage in the natural history of the disease. Recent data point to novel therapeutic strategies, one of which is to use strontium ranelate in order to delay the progression of chondrolysis in knee and hip OA.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартроз</kwd><kwd>субхондральная кость</kwd><kwd>суставной хрящ</kwd><kwd>структурно-модифицирующее действие</kwd><kwd>стронция ранелат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>OPG-RANK-RANKL</kwd><kwd>osteoarthrosis</kwd><kwd>subchondral bone</kwd><kwd>articular cartilage</kwd><kwd>OPG-RANK-RANKL</kwd><kwd>structure-modifying activity</kwd><kwd>strontium ranelate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
