mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2013-274mrj-498Research ArticleСтатьиArticlesРевматические проявления эндокринных болезней: болезни скелета при гипопаратиреозеRheumatic manifestations of endocrine diseases: skeletal diseases in hypoparathyroidismБарсковаВ. Г.BarskovaViktoria Georgiyevnabarskova@irramn.ruВладимировС. А.VladimirovS Abarskova@irramn.ruБочковаА. Г.BochkovaA Gbarskova@irramn.ruКудаеваФ. М.KudaevaF Mbarskova@irramn.ruСмирновА. В.SmirnovA Vbarskova@irramn.ruБожьеваЛ. А.BozhyevaL Abarskova@irramn.ruНасоновЕвгений ЛьвовичNasonovE Lbarskova@irramn.ruФГБУ «Научно-исследовательский институт ревматологии им. акад. В.А. Насоновой» РАМН, МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, MoscowRussian Federation20131410201373№3 (2013)5863Copyright © Барскова В.Г., Владимиров С.А., Бочкова А.Г., Кудаева Ф.М., Смирнов А.В., Божьева Л.А., Насонов Е.Л., 20132013Барскова В.Г., Владимиров С.А., Бочкова А.Г., Кудаева Ф.М., Смирнов А.В., Божьева Л.А., Насонов Е.Л.Barskova V.G., Vladimirov S.A., Bochkova A.G., Kudaeva F.M., Smirnov A.V., Bozhyeva L.A., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/498

Болезни паращитовидной железы вызывают серьезные мышечно-скелетные проблемы. Основная функция паратиреоидного гормона (ПГ) – регулирование уровня кальция в организме, тесно связана с витамином D. ПГ оказывает двойное действие на скелет человека: анаболическое и катаболическое, что объясняет его разнонаправленное влияние на кость и  основные клинические проявления заболеваний, связанных с его гипер- или гипопродукцией. В статье рассматриваются основные причины гипопаратиреоза (ГПТ), под которым понимается состояние неадекватной активности и/или секреции ПГ, при этом уровень ионизированного кальция падает ниже референсных значений. Приводятся два случая ГПТ, при которых наблюдалась клиническая картина, напоминающая анкилозирующий спондилит.

Parathyroid diseases cause serious musculoskeletal problems. The major function of parathyroid hormone (PTH) is to regulate calcium levels in the body, which is closely related to vitamin D. PTH exerts a double (anabolic and catabolic) effect on the human skeleton, which accounts for its heterogeneous action on the bone and for the major clinical manifestations of diseases associated with its hyper- and hypoproduction. The paper considers the main causes of hypoparathyroidism (HPT) that is considered to mean inadequate PHT activity and/or secretion; moreover, the level of ionized calcium falls below the reference range. It describes two HPT cases that show the clinical picture resembling ankylosing spondylitis.

гипопаратиреозанкилозирующий спондилитhypoparathyroidismankylosing spondylitisReferences<div><p>Goltzman D, Cole DEC. Hypoparathyroidism. In: Favus MJ, editor. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Philadelphia: Lippincott-Raven; 1996. р. 220–3.</p><p>Wen HY., Shumacher HR, Zhang LY. Parathyroid disease. In: Markenson JA, editor. Rheumatologic Manifestations of Endocrine Disease. Nov 2010;36(4):647–59.</p><p>Bhadada SK, Bhansali A, Upreti V et al. Spectrum of neurological manifestations of idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neurol India. Jul-Aug 2011;59(4):586–9. [Medline].</p><p>Assfaw Z, Assefa G. Basal ganglia calcification with hypoparathyroidism: a case report. Ethiop Med J. Jul 2011;49(3):273–7. [Medline].</p><p>Goswami R, Goel S, Tomar N et al. Prevalence of clinical remission in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 2009 Jun 22;72(3):328–33. [Medline].</p><p>Rubin MR, Dempster DW, Zhou H et al. Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res. Dec 2008;23(12):2018–24. [Medline].</p><p>Ebrahimi H, Edhouse P, Lundgren CI et al. Does autoimmune thyroid disease affect parathyroid autotransplantation and survival? ANZ J Surg. May 2009;79(5):383–5. [Medline].</p><p>Brown EM. Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism. Endocrinol Metab Clin North Am. Jun 2009;38(2):437–45. [Medline].</p><p>Goltzman D, Cole DEC. Hypoparathyroidism. In: Favus MJ editor. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Philadelphia: Lippincott-Raven; 1996. р. 220–3.</p><p>Cheung M. Drugs used in paediatric bone and calcium disorders. Endocr Dev. 2009;(16):218–32. [Medline].</p><p>Brown EM, Harris HW, Vassilev PM. The biology of the extracellular Ca2+-sensing receptor. In: Bilezikian JP editor. Principles of Bone Biology. San Diego: Academic Press; 1996. р. 243–62.</p><p>Cole DEC, Hendy GN. Hypoparathyroidism and pseudohypoparathyroidism. Endotext com. 2005. Аvailable from [Full Text].</p><p>Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000 Dec 21;343(25):1863–75. [Medline].</p><p>Thakker RV. Molecular basis of PTH underexpression. In: Bilezikian JP et al., editors. Principles of Bone Biology. San Diego: Academic Press; 1996. р. 837–51.</p></div><br /><div><p>Goltzman D, Cole DEC. Hypoparathyroidism. In: Favus MJ, editor. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Philadelphia: Lippincott-Raven; 1996. р. 220–3.</p><p>Wen HY., Shumacher HR, Zhang LY. Parathyroid disease. In: Markenson JA, editor. Rheumatologic Manifestations of Endocrine Disease. Nov 2010;36(4):647–59.</p><p>Bhadada SK, Bhansali A, Upreti V et al. Spectrum of neurological manifestations of idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neurol India. Jul-Aug 2011;59(4):586–9. [Medline].</p><p>Assfaw Z, Assefa G. Basal ganglia calcification with hypoparathyroidism: a case report. Ethiop Med J. Jul 2011;49(3):273–7. [Medline].</p><p>Goswami R, Goel S, Tomar N et al. Prevalence of clinical remission in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 2009 Jun 22;72(3):328–33. [Medline].</p><p>Rubin MR, Dempster DW, Zhou H et al. Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res. Dec 2008;23(12):2018–24. [Medline].</p><p>Ebrahimi H, Edhouse P, Lundgren CI et al. Does autoimmune thyroid disease affect parathyroid autotransplantation and survival? ANZ J Surg. May 2009;79(5):383–5. [Medline].</p><p>Brown EM. Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism. Endocrinol Metab Clin North Am. Jun 2009;38(2):437–45. [Medline].</p><p>Goltzman D, Cole DEC. Hypoparathyroidism. In: Favus MJ editor. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Philadelphia: Lippincott-Raven; 1996. р. 220–3.</p><p>Cheung M. Drugs used in paediatric bone and calcium disorders. Endocr Dev. 2009;(16):218–32. [Medline].</p><p>Brown EM, Harris HW, Vassilev PM. The biology of the extracellular Ca2+-sensing receptor. In: Bilezikian JP editor. Principles of Bone Biology. San Diego: Academic Press; 1996. р. 243–62.</p><p>Cole DEC, Hendy GN. Hypoparathyroidism and pseudohypoparathyroidism. Endotext com. 2005. Аvailable from [Full Text].</p><p>Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000 Dec 21;343(25):1863–75. [Medline].</p><p>Thakker RV. Molecular basis of PTH underexpression. In: Bilezikian JP et al., editors. Principles of Bone Biology. San Diego: Academic Press; 1996. р. 837–51.</p></div><br />

The authors declare that there are no conflicts of interest present.