mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2014-3-41-44mrj-559Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSВзаимосвязь минеральной плотности костной ткани и показателей иммунного воспаления у женщин с остеопорозом в сочетании с ишемической болезнью сердцаRelationship between bone mineral density and immune inflammatory parameters in women with osteoporosis concurrent with coronary heart diseasesЦаренокC. Ю.TsarenokS. Yu.sveta-tsarenok@yandex.ruГорбуновВ. В.GorbunovV. V.АксеноваТ. А.AksenovaT. A.ГБОУ ВПО «Читинская государственная медицинская академия», Чита, Россия 672090, Чита, ул. Горького, 39АРоссияChita State Medical Academy, Chita, Russia 39A, Gorky St., Chita 672090Russian Federation201422092014834144Copyright © Царенок C.Ю., Горбунов В.В., Аксенова Т.А., 20142014Царенок C.Ю., Горбунов В.В., Аксенова Т.А.Tsarenok S.Y., Gorbunov V.V., Aksenova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/559

Низкая минеральная плотность кости (МПК) является фактором риска остеопоротических переломов. Известна роль системы RANKL–RANK–OPG и некоторых цитокинов в регуляции костного ремоделирования. Цитокины и остеопротегерин (OPG) способны оказывать влияние и на сердечно-сосудистую систему. Изучение взаимосвязи между МПК и уровнем цитокинов у пациентов, имеющих сочетание остеопороза (ОП) и коронарного атеросклероза, представляется весьма актуальным.

Цель исследования – оценить взаимосвязь МПК и уровня цитокинов, OPG у женщин с ОП, коморбидным с ишемической болезнью сердца (ИБС).

Материал и методы

Материал и методы. Обследовано 60 женщин с ОП, коморбидным с ИБС (1-я группа), средний возраст – 68,7±8,8 года, контрольную группу (2-я группа) составили 38 пациенток с изолированной ИБС, средний возраст – 69,4±8,1 года. МПК исследовали в двух областях – поясничных позвонках LI–IV и проксимальном отделе бедра при помощи DEXA денситометра CHALLENGER (Франция). Уровни ОPG интерлейкина (ИЛ) 1β, 4, 6, 8, 10, фактора некроза опухоли (ФНО) α в сыворотке крови определяли методом иммуноферментного анализа (ELISA).

Результаты исследования

Результаты исследования. У женщин с коморбидной патологией отмечается повышение уровня ИЛ6 и 8, ФНОα, ИЛ4, 10, OPG. Выявлена отрицательная связь между уровнями ИЛ1, ФНОα, ИЛ8 и МПК позвонков; концентрации OPG, ИЛ4, 6, 8 и ФНОα были обратно связаны с МПК шейки бедра. Независимым фактором снижения МПК в шейке бедра является ИЛ6, в поясничных позвонках – ИЛ1. Полученные данные свидетельствуют о взаимосвязи между повышением уровня цитокинов и снижением МПК у женщин с ОП, коморбидным с ИБС.

Low bone mineral density (BMD) is a risk factor of osteoporotic fractures. The RANKL–RANK–OPG system and some cytokines are known to play a role in the regulation of bone remodeling. Cytokines and osteoprotegerin (OPG) are able to affect the cardiovascular system. It is highly relevant to study the relationship between BMD and cytokine levels in patients with a concurrence of osteoporosis (OP) and coronary atherosclerosis.

Objective

Objective: to estimate the relationship between BMD and the level of cytokines and OPG in women having OP comorbid with coronary heart disease (CHD).

Subjects and methods

Subjects and methods. Sixty women (mean age 68.7±8.8 years) with OP comorbid with CHD (Group 1) were examined; a control group consisted of 38 patients (mean age 69.4±8.1 years) with isolated CHD (Group 2). BMD was measured in two regions: lumbar vertebrae (LI–IV) and proximal femur, by employing a DEXA densitometer (CHALLENGER, France). The serum levels of OPG, interleukin (IL) 1β, 4, 6, 8, 10, and tumor necrosis factor (TNF) α were determined by enzyme-linked immunosorbent assay (ELISA).

Results

Results. The women with comorbidity were observed to have elevated IL6, 8, TNF-α, IL4, 10, and OPG levels. There was a negative correlation between IL1, TNF-α, and IL8 levels and vertebral BMD; OPG, IL4, 6, 8, and TNF-α concentrations were inversely related to femoral neck BMD. The independent factor of lower BMD was IL6 in the femoral neck and IL1 in the lumbar vertebrae. The findings suggest that there is a relationship between elevated cytokine levels and lower BMD in women having OP comorbid with CHD.

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The authors declare that there are no conflicts of interest present.