References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2014-3-66-72

mrj-563

Research Article

ОБЗОРЫ

REVIEWS

Современные представления о формировании механизмов болевого синдрома у пациенто в с о стеоартрозом. Рациональная фармакотерапия

Current views of the development of pain syndrome mechanisms in patients with osteoarthrosis. Rational pharmacotherapy

Иголкина

Е. В.

Igolkina

E. V.

mmirevmdok@yandex.ru

ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России, Москва, Россия 101000, Москва, ул. Трубецкая, д. 8, стр. 2РоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia 8, Trubetskaya St., Build. 2, Moscow 101000Russian Federation

2014

22092014

836672

2014

Иголкина Е.В.

Igolkina E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/563

В статье изложены современные представления о механизмах развития боли при остеоартрозе (ОА). Проблема аналгезии при ОА остается нерешенной, что дает основание для более пристального изучения механизмов развития боли при ОА. Имеется ли повреждение периферических соматосенсорных нервов при ОА, – этот вопрос является предметом пристального изучения и дискуссий. Приведены результаты исследований, посвященных изучению неврогенного компонента боли у пациентов с ОА. Получено достаточно доказательств наличия сенсорных аномалий, сопровождающих боль при ОА. В клинической практике для идентификации центральной сенситизации у пациентов с ОА может оказаться полезным использование опросников для выявления невропатической боли. Представлена характеристика препаратов для симптоматической терапии боли.

The paper outlines the current views on mechanisms for pain development in osteoarthrosis (OA). The problem of analgesia in OA remains to be solved, which gives rise to a more careful study of the mechanisms in OA. Whether peripheral somatosensory nerve damage occurs in OA is the subject of careful investigation and dispute. The paper gives the results of studies of the neurogenic component of pain in OA patients. There is sufficient evidence for the presence of sensory anomalies accompanying pain in OA. The clinical use of questionnaires to detect neuropathic pain may assist in identifying central sensitization in patients with OA. Medicaments for the symptomatic therapy of pain are characterized.

больостеоартрозноцицепцияневропатическая больлечение боли

painosteoarthrosisnociceptionneuropathic painpain treatment

References1

Pelletier J-P, Martel-Pelletier J., Abramson SB. Ostheoarthritis an inflammatory disease. Arthritis Rheum. 2001;44(6):1237–47. DOI: http://dx.doi.org/ 10.1002/15290131(200106)44:6%3C1237::AI D-ART214%3E3.0.CO;2-F.

Pincus T. Clinical evidence for osteoarthritis as an inflammatory disease. Curr Rheum Rep. 2006;3(6):524–34. DOI: http://dx.doi.org/10.1007/s11926-001-0068-4.

Brandt KD. Diagnosis and nonsurgical management of osteoarthritis. 2nd ed. Professional Communications, Inc., Caddo, OK. 2000. 304 p.

Бадокин ВВ. Значение воспаления в развитии и течении остеоартроза. Consilium medicum. 2009;11(9):91-5. [Badokin VV. Value of an inflammation in development and the course of osteoarthrosis. Consilium medicum. 2009;11(9):91–5. (In Russ.)]

Brandt KD. The mechanism of action of nonsteroidal anti-inflammatory drugs. J Rheumatol. 1991;(18):120–1.

Doherty M. Chondroprotection by nonsteroidal anti-inflammatory drugs. Ann Rheum Dis. 1989;48(8):619–21. DOI: http://dx.doi.org/10.1136/ard.48.8.619.

Garsia-Rodriguiz LA, Hermandes-Diaz S. The relative risk of upper gastrointestinal complications among users of acetaminophen and non-steroidal anti-unflammatori drugs. Epidemiology. 2001;12(5):570–6. DOI: http://dx.doi.org/10.1097/00001648-200109000-00018.

Кукушкин МЛ, Хитров НК. Общая патология боли. Москва: Медицина; 2004. 144 с. [Kukushkin ML, Khitrov NK. Obshchaya patologiya bol [General pathology of pain]. Moscow: Meditsina; 2004. 144 p.]

Schaible H-G, Grubb BD. Afferent and spinal mechanisms of joint pain. Pain. 1993;55(1):5–54. DOI: http://dx.doi.org/10.1016/0304-3959(93)90183-P.

Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxios conditioning stimulation in patients with painful osteoarthritis before, but not following, surgicalpain relief. Pain. 2000:88(1):69–78. DOI: http://dx.doi.org/10.1016/S0304- 3959(00)00310-9.

Pain mechanism and management in the rheumatic diseases. Rheumatic Disease Clinics of North America. 2008;34:267–507.

Hawker G, Gignac M, Badley E, et al. A longitudinal study to explain the paindepression link in older adults with osteoarthritis. Arthritis Care Res (Hoboken). 2010;63(10):1382–90. DOI: 10.1002/acr.20298. Epub 2010 Jul 26.

Merskey H, Bogduk N. Classification of Cronic Pain. Task Force on Taxonomy. Seattle: IASP Press; 1994. C. 209–14.

Treed RD, Jensen TS, Campbell JN, et al. Neuropatic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70(18):1630–5. DOI: http://dx.doi.org/10.1212/01.wnl.0000282763.29778.59. Epub 2007 Nov 14.

Baron R. Mechanisms of disease: neuropatic pain, a clinical perspective. Nat Clin Pract Neurol. 2006;2(2):95–106. DOI: http://dx.doi.org/10.1038/ncpneuro0113.

Freynhagen R, Baron R, Gockel U, Tolle T. PainDETECT: a new scrining questinnare to identify neuropathic components in patients with back pain. Curr Med Res Opin. 2006;22(10):1911–20. DOI: http://dx.doi.org/10.1185/030079906X132488.

Thakur M, Dickenson AH and Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014;10(6):374–80. DOI: 10.1038/nrrheum.2014,47. Epub 2014 Apr 1.

Orita S, Ishikawa T, Miyagi M, et al. Pain-related sensory innervation in monoiodoacetate-induced ostheoarhritis in rat knees that gradually develops neuronal injure in addition to inflammatory pain. BMC Musculoskelet Disord. 2011;12:134. DOI: 10.1186/1471-2474-12-134.

Ivanavicius SP, Ball AD, Heapy CG, et al. Strucrural pathology in a rodent model of osteoarthritis is assotiated with neuropatic pain: increased expression of ATF-3 and pharmacological characterization. Pain. 2007;128(3):272–82. DOI: http://dx.doi.org/10.1016/j.pain.2006.12.022.

Thakur M, Rahman W, Hobbs C, et al. Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of ostheoarthrites. PLoS ONE. 2012;7(3):e33730. DOI: 10.1371/journal.pone.0033730. Epub 2012 Mar 21.

Kelly S, Dunham JP, Murrey F, et al. Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint associated mechanoreceptive ptimary afferent neurons during MIA – induced ostheoarthritis in the rat. Ostheoarthritis Cartilage. 2012;20(4):305–13. DOI: 10.1016/j.joca.2012.01.002. Epub 2012 Jan 10.

Oteo-Alvaro A, Ruiz-Iban MA, Miguens X, et al. High Prevalence of Neuropathic Pain Features in Patients with Knee Osteoarthritis: A Cross-Sectional Study. Pain Pract. 2014 Apr 21. DOI: 10.1111/papr.12220.

Suri S, Gill SE, Camin M, et al. Neurovascular invasion at the osteochondral junction and in osteophites in osteoarthritis. Ann Rheum Dis. 2007;66(11):1423–8. DOI: http://dx.doi.org/10.1136/ard.2006.063354. Epub 2007 Apr 19.

Wolsh DA, McWilliams DF, Turley MJ, et al. Angiogenesis and nerve growth factor at the at the osteochondral junction in rheumatoid rthritis and osteoarthritis.Rheumatology (Oxford). 2010;49(10):1852–61. DOI: 10.1093/rheumatology/keq188. Epub 2010 Jun 26.

Eitner A, Pester J, Nietzsche S, et al. The innervation of sinovium of human osteoarthritic joints in comparison with normal rat and sheep synovium. Osteoarthtitis Cartilage. 2013;21(9):1383–91. DOI: 10.1016/j.joca.2013.06.018.

Wilde V, Palmer S, Learmonth ID, Dieppe P. Somatosensory abnormalities in knee OA. Rheumatology (Oxford). 2012;51(3):535–43. DOI: 10.1093/rheumatology/ ker343. Epub 2011 Nov 24.

Arendt-Nielsen L, Nie H, Laursen MB, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010;149(3):573–81. DOI: 10.1016/j.pain.2010.04.003. Epub 2010 Apr 24.

Imamura M, Imamura ST, Kaziyama HH, et al. Impact of nervous system hyperalgesia on pain, disabilite, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum. 2008;59(10):1424–31. DOI: 10.1002/art.24120.

Hochman JR, Davis AM, Elkayam J, et al. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1236–42. DOI: 10.1016/j.joca.2013.06.023.

Gwylim SE, Keltner JR, Warnaby CE, et al. Psycholophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 2009;61(9):1226–34. DOI:10.1002/art.24837. 31. Wilde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: prevalence, sensory qualities and postoperative determinants. Pain. 2011;152(3):566–72. DOI: 10.1016/j.pain.2010.11.023. Epub 2011 Jan 15.

Ohtori S, Orita S, Yamashita M, et al. Existance of neuropathic pain component in patients with osteoarthritis of the knee. Yonsei Med J. 2012;53(4):801–5. DOI: 10.3349/ymj.2012.53.4.801.

Soni A, Batra RN, Gwilym SE, et al. Neuropathic features of joint pain: a community- based study. Arthritis Rheum. 2013;65(7):1942–9. DOI: 10.1002/art.37962.

Suokas AK, Walsh DA, McWilliams DF, et al. Quantitative sensory testing in painful osteoarthritis: a systematic review and metaanalysis. Osteoarthritis Cartilage. 2012;20(10):1075–85. DOI: 10.1016/j.joca.2012.06.009. Epub 2012 Jul 13.

Hochman JR, Gagliese L, Davis AM, Hawker GA. Neuropathic pain symptoms in a community knee OA cohort. Osteoarthritis Cartilage. 2011;19(6):647–54. DOI: 10.1016/j.joca.2011.03.007. Epub 2011 Apr 8.

Hochman GR, French MR, Bermingham SL, Hawker GA. The nerve of osteoarthritis pain. Arthritis Care Res (Hoboken). 2010;62(7):1019–23. DOI: 10.1002/acr.20142.

Яхно НН, редактор. Методические рекомендации по диагностике и лечению невропатической боли. Москва: РАМН; 2008. С. 5-7. [Yakhno NN, editor. Metodicheskie rekomendatsii po diagnostike i lecheniyu nevropaticheskoi boli [Methodical recommendations about diagnostics and treatment of nevropatichesky pain]. Moscow: RAMN; 2008. P. 5–7.]

Инструкция по применению лекарственного препарата для медицинского применения Лирика® от 20.07.2011. РУ № ЛС - 0011752 от 20.07.2011, с изм. от 20.08.2012. [Instruktsiya po primeneniyu lekarstvennogo preparata dlya meditsinskogo primeneniya Lirika® ot 20.07.2011 [The instruction on use of medicine for medical application of Lirika® of 20.07.2011]. RU № LS - 0011752 of 20.07.2011, s izm. ot 20.08.2012.]

Roth T, van Seventer R, Murphy TK. The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. Curr Med Res Opin. 2010 Oct;26(10):2411Р9. DOI: http://dx.doi.org/ 10.1185/03007995.2010.516142.

Argoff CE, Backonja MM, Belgrade MJ, et al. Consensus guidelines: treatment planning and options. Diabetic peripheral neuropathic pain. Mayo Clin Proc. 2006;81 (4 Suppl):S12Р25. DOI: http://dx.doi.org/10.1016/S0025-6196(11)61475-4.

Moulin DE, Clark AJ, Gilron I, et al. Pharmacological management of chronic neuropathic pain Р consensus statement and guidelines from the Canadian Pain Society. Pain Res Manag. 2007;12(1):13–21. 42. Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment on neuropathic pain: 2009 revision. Eur J Neurol. 2010;17(9):1113Рe88. DOI: 10.1111/j.1468-1331.2010.02999.x. Epub 2010 Apr 9.

Bohlega S, Alsaadi T, Amir A, et al. Guidelines for the pharmacological treatment of peripheral neuropathic pain: expert panel recommendations for the middle East region. J Int Med Res. 2010;38:295–317. DOI: http://dx.doi.org/10.1177/ 147323001003800201.

Fehrenbacher JC, Tailor CP, Vasko MR. Pregabalin and gabapentin reduce release of substance – and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. Pain. 2003;105(1–2):133–41.

Ohtori S, Inoue G, Orita S, et al. Efficacy of combination of meloxicam and pregabalin for pain in knee ostheoarthritis. Yonsei Med J. 2013;54(5):1253–8. DOI: 10.3349/ymj.2013.54.5.1253.

Buvanendran A, Kroin JS, Della Valle CJ, et al. Perioperative oral pregabalin reduces chronic pain after total knee arthroplastiy: a prospective, randomized, controlled trial. Anesth Analg. 2010;110(1):199–207. DOI: 10.1213/ANE.0b013e3181c4273a. Epub 2009 Nov 12.

Steigerwald I, Schenk M, Lahne U, et al. Effectiveness and tolerability of tapentadol prolonged release compared with prior opioid therapy for the management of severe, chronic ostheoarthritis pain. Clin Drug Investig. 2013;33(9):607–19. DOI: 10.1007/s40261-013-0102-0.

The authors declare that there are no conflicts of interest present.