mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2014-4-90-95mrj-581Research ArticleОБЗОРЫREVIEWSДостоинства и недостатки диацереинаDiacerein: Advantages and disadvantagesКаратеевАндрей ЕвгеньевичKarateevAndrei Evgenyevich

115522, Россия, Москва, Каширское шоссе, д. 34А

34A, Kashirskoe Shosse, Moscow Russia 115552

aekarateev@rambler.ruФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201403122014849095Copyright © Каратеев А.Е., 20142014Каратеев А.Е.Karateev A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/581

Диацереин (ДР) – препарат из группы медленнодействующих симптоматических средств («хондропротекторов»), который обладает оригинальным механизмом действия и широко используется в России и многих странах мира для лечения остеоартроза (ОА). Способность ДР влиять на основные симптомы и прогрессирование ОА была показана в ходе серии хорошо организованных клинических исследований. Однако в настоящее время контролирующие медицинские органы Евросоюза приняли решение о введении ограничений на использование ДР, что связано с изменением точки зрения на уровень безопасности этого препарата. Речь идет об осложнениях со стороны желудочно-кишечного тракта (диарея) и гепатотоксических реакциях, которые могут возникать при лечении ДР. В настоящем обзоре рассмотрены результаты наиболее известных клинических исследований ДР, представлены основные данные о его нежелательных реакциях и оценена перспектива использования новых генериков этого препарата.

Diacerein (DR) is a medication from a group of symptomatic slow-acting agents (chondroprotectors), which has an original mechanism of action and is widely used in Russia and many countries in the world to treat osteoarthrosis (OA). The ability of DR to affect its major symptoms and progression has been shown in a series of well-organized clinical trials. However, the supervisory health bodies of the European Union have presently made a decision to restrict the use of DR, which is associated with the fact that the viewpoint of this drug's safety level has been changed. The case in point is gastrointestinal complications (diarrhea) and hepatotoxic reactions, which may be caused by DR treatment. This review considers the results of the most known clinical trials of DR, gives basic data on its adverse reactions, and assesses prospects for using its new generic drugs.

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The authors declare that there are no conflicts of interest present.