mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2015-4-48-53mrj-653Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSПриверженность лечению деносумабом, его эффективность и безопасность в клинической практике у женщин с постменопаузальным остеопорозомAdherence to treatment with denosumab, its efficacy and safety in women with postmenopausal osteoporosis in clinical practiceТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

torop@irramn.ruНикитинскаяО. А.NikitinskayaO. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

КоротковаТ. А.KorotkovaT. A.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ДеминН. В.DeminN. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201513012016944853Copyright © Торопцова Н.В., Никитинская О.А., Короткова Т.А., Демин Н.В., 20162016Торопцова Н.В., Никитинская О.А., Короткова Т.А., Демин Н.В.Toroptsova N.V., Nikitinskaya O.A., Korotkova T.A., Demin N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/653

Приверженность лечению антиостеопоротическими препаратами является одним из важных факторов, вносящих вклад в их эффективность при длительном лечении. Приверженность оценивается по двум основным направлениям: во-первых, как длительно принимается препарат, и, во-вторых, соблюдается ли режим дозирования.

Пациенты и методы

Пациенты и методы. В статье представлены данные 12-месячного проспективного наблюдения за 40 женщинами с постменопаузальным остеопорозом (ОП), начавших лечение генно-инженерным препаратом деносумаб.

Результаты и обсуждение

Результаты и обсуждение. Достоверный прирост минеральной плотности кости через 12 мес наблюдения составил 4,97% в поясничном отделе позвоночника, 3,2% – в шейке бедра, 3,0% – в общем показателе бедра. Предшествующий прием других противоостеопоротических препаратов не снижал эффективности лечения деносумабом. Не было случаев остеопоротических переломов за год наблюдения. Две инъекции деносумаба (годовой курс) получили 95% пациенток, при этом соблюдение режима дозирования было отмечено у 90% женщин. На приверженность лечению в течение 12 мес не оказывали влияния возраст, семейное положение, уровень образования, время на дорогу до клиники, наличие переломов бедра у родителей, переломы в анамнезе, длительность ОП и предшествующая терапия.

Заключение

Заключение. Проведенное одногодичное проспективное наблюдение, выполненное в условиях амбулаторной практики, показало, что деносумаб – эффективное и безопасное средство для лечения больных с постменопаузальным ОП, а режим дозирования, разумевающий редкое его введение (2 раза в год подкожно), обеспечил высокую приверженность терапии.

Adherence to treatment with antiosteoporotic drugs is one of the most important factors contributing to their efficacy during longterm therapy. The adherence is assessed by two main lines: firstly, how long a drug is taken and, secondly, whether its dosage regimen is adhered.

Subjects and methods

Subjects and methods. The paper gives the data of a 12-month prospective follow-up study of 40 women with postmenopausal osteoporosis (OP) who initiated treatment with the biological agent denosumab.

Results and discussion

Results and discussion. After the 12-month follow-up, the significant bone mineral density increase was 4.9% in the lumbar spine, 3.2% in the femoral neck, and 3.0% in the total hip. The previous administration of other antiosteoporotic drugs did not lower the efficiency of denosumab therapy. There were no cases of osteoporotic fractures during 1-year follow-up. 95% of the patients received two denosumab injections (an annual cycle); moreover, 90% of the women were noted to adhere to the dosage regimen. Age, marital status, level of education, time taken to reach the clinic, parental femoral fractures, a history of fractures, duration of OP, and previous therapy had no impact on treatment adherence during 12 months.

Conclusion

Conclusion. The one-year prospective follow-up study of the outpatients demonstrated that denosumab was an effective and safe agent for the treatment of patients with postmenopausal OP and its dosage regimen implying its rare subcutaneous administration (twice yearly) ensured the high patient adherence to therapy.

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The authors declare that there are no conflicts of interest present.