mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2015-4-83-91mrj-658Research ArticleОБЗОРЫREVIEWSСовременные представления о фармакотерапии псориатического артритаCurrent views on the pharmacotherapy of psoriatic arthritisТарадинГ. Г.TaradinG. G.

84404, Донецкая область, г. Красный Лиман, ул. Кирова, 27

27, Kirov St., Krasnyi Liman, Donetsk Region 84404

taradin@inbox.ruВатутинН. Т.VatutinN. T.

84404, Донецкая область, г. Красный Лиман, ул. Кирова, 27

27, Kirov St., Krasnyi Liman, Donetsk Region 84404

АнтоненкоД. В.AntonenkoD. V.

84404, Донецкая область, г. Красный Лиман, ул. Кирова, 27

27, Kirov St., Krasnyi Liman, Donetsk Region 84404

СмирноваА. С.SmirnovaA. S.

84404, Донецкая область, г. Красный Лиман, ул. Кирова, 27

27, Kirov St., Krasnyi Liman, Donetsk Region 84404

Донецкий национальный медицинский университет им. М. ГорькогоУкраинаM. Gorky Donetsk National Medical UniversityUkraine201514012016948391Copyright © Тарадин Г.Г., Ватутин Н.Т., Антоненко Д.В., Смирнова А.С., 20162016Тарадин Г.Г., Ватутин Н.Т., Антоненко Д.В., Смирнова А.С.Taradin G.G., Vatutin N.T., Antonenko D.V., Smirnova A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/658

Обзор посвящен современным фармакологическим подходам к лечению псориатического артрита (ПсА). Приведены данные о распространенности псориаза и псориатического поражения суставов, нередко являющегося причиной ранней инвалидизации больных. Подходы к оценке эффективности препаратов даны на основании разработанных и используемых критериев, с учетом стандартизованной оценки динамики суставного поражения ревматических заболеваний и, в частности, ПсА. Представлена краткая информация о механизме действия препаратов, приведены результаты клинических исследований, в которых оценивались эффективность и безопасность различных лекарственных средств при ПсА. Обзор охватывает опыт применения нестероидных противовоспалительных препаратов, глюкокортикоидов, синтетических базисных противовоспалительных препаратов (метотрексат, циклоспорин, лефлуномид, сульфасалазин), а также перспективную группу генно-инженерных биологических препаратов. Особое внимание уделено результатам применения ингибиторов фактора некроза опухоли (этанерцепт, инфликсимаб, голимумаб, цертолизумаба пэгол, адалимумаб), ингибиторов интерлейкинов (устекинумаб, бродалумаб) и ингибиторов фосфодиэстеразы 4 (апремиласт).

The review deals with current pharmacological approaches to treating psoriatic arthritis (PsA). It gives data on the prevalence of psoriasis and psoriatic joint injury that is a common cause of early patient disability. Approaches to evaluating the efficacy of drugs are given on the basis of developed and used criteria with regard to the standardized assessment of the dynamics of joint injury in rheumatic diseases and PSA in particular. The review gives brief information on the mechanism of drug actions and the results of clinical trials evaluating the efficacy and safety of different medicaments in PsA. It also covers the experience in using nonsteroidal antiinflammatory drugs, glucocorticoids, synthetic diseasemodifying antirheumatic drugs (methotrexate, cyclosporine, leflunomide, sulfasalazine), and also a promising group of biologicals. Particular emphasis is placed on the results of using tumor necrosis factor inhibitors (etanercept, infliximab, golimumab, certolizumab pegol, adalimumab), interleukin inhibitors (ustekinumab, brodalumab), and phosphodiesterase 4 inhibitors (apremilast).

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The authors declare that there are no conflicts of interest present.