References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2016-2-56-63

mrj-685

Research Article

ОБЗОРЫ

REVIEWS

Клеточно-молекулярные механизмы развития остеопороза: современные концепции и будущее направление терапии

Cellular and molecular mechanisms of osteoporosis: current concepts and future direction treatment

Долженко

А. Т.

Dolzhenko

A. T.

Сагаловски

С.

Sagalovsky

s.sagalovsky@gmail.com

Институт молекулярной медицины, Университет им. Мартина Лютера Галле-Виттенберг, ГерманияРоссияBiomedical Research Unit, Institute of Molecular Medicine Martin-Luther University Halle-Wittenberg, Germany, Bad Lausick, GermanyRussian Federation

Отдел ортопедии клиники Медиан, Бад Лаузик, ГерманияРоссияDepartment of Orthopedics Median Clinic, Bad Lausick, GermanyRussian Federation

2016

05062016

1025663

2016

Долженко А.Т., Сагаловски С.

Dolzhenko A.T., Sagalovsky S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/685

В обзоре литературы представлены современные взгляды на клеточно-молекулярные механизмы развития ремоделирования кости и патогенез остеопороза. Открытие цитокиновой системы RANKL-RANK-OPG и значительной роли катепсина К в процессе ремоделирования костной ткани способствовало значительному прогрессу в понимание механизмов развития остеопороза и позволило разработать препараты нового поколения – деносумаб, полностью человеческое моноклональное антитело к RANKL (receptor activator nucleus factor kappa B ligand), и ингибитор катепсина К оданакатиб, угнетающие процесс резорбции костной ткани.

The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has made progress in understanding the mechanisms development disease and possible to development drugs of the new generation – denosumab, a fully human RANKL monoclonal antibody and inhibitor cathepsin K odanacatib that inhibits of the bone resorption.

остеопорозRANKL-RANK-OPG-сигнальный путькатепсин Кденосумабоданакатиб

osteoporosisRANKL-RANK-OPG-signaling pathwaycathepsin Kdenosumabodanacatib

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The authors declare that there are no conflicts of interest present.