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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mrj</journal-id><journal-title-group><journal-title xml:lang="ru">Современная ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Modern Rheumatology Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1996-7012</issn><issn pub-type="epub">2310-158X</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1996-7012-2016-4-92-96</article-id><article-id custom-type="elpub" pub-id-type="custom">mrj-725</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>О МЕСТЕ ПРЕПАРАТОВ ГИАЛУРОНОВОЙ КИСЛОТЫ У ПАЦИЕНТОВ С РАЗНЫМИ ФЕНОТИПАМИ ОСТЕОАРТРИТА КОЛЕННЫХ СУСТАВОВ</article-title><trans-title-group xml:lang="en"><trans-title>THE PLACE OF HYALURONIC ACID PREPARATIONS IN PATIENTS WITH DIFFERENT PHENOTYPES OF KNEE OSTEOARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплякова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplyakova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Контакты: Ольга Вячеславовна Теплякова; ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России, 620028, Екатеринбург, ул. Репина, 3</p></bio><bio xml:lang="en"><p>Contact: Olga Vyacheslavovna Teplyakova; Ural State Medical University, Ministry of Health of Russia,  3, Repin St., Yekaterinburg 620028 </p></bio><email xlink:type="simple">oteplyakova69@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Уральский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2016</year></pub-date><volume>10</volume><issue>4</issue><fpage>92</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Теплякова О.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Теплякова О.В.</copyright-holder><copyright-holder xml:lang="en">Teplyakova O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://mrj.ima-press.net/mrj/article/view/725">https://mrj.ima-press.net/mrj/article/view/725</self-uri><abstract><p>Обсуждается проблема фенотипирования остеоартрита (ОА) коленного сустава. Сделано предположение, что существующие противоречия между клиническими рекомендациями разных лет, как и недостаточная эффективность их практического использования, могут быть связаны с клиническими особенностями отдельных фенотипов ОА, что имеет большое значение для развития индивидуальных терапевтических подходов у таких пациентов. Рассмотрено место Hylan G-F 20 в алгоритме лечения ОА коленного сустава с учетом разных вариантов течения заболевания. </p></abstract><trans-abstract xml:lang="en"><p>The paper discusses the problem of phenotyping of knee osteoarthritis (OA). It is assumed that that existing differences between clinical recommendations of different years, as the inadequate efficiency of their practical application, may be associated with the clinical features of individual OA phenotypes. It is of great importance in selecting individual therapeutic approaches in these patients. The place of Hylan G-F20 inthe treatment algorithm for knee OA is considered, by taking into account different types of the disease. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>коленный сустав</kwd><kwd>фенотипы</kwd><kwd>гиалуроновая кислота</kwd><kwd>Hylan G-F 20</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>knee joint</kwd><kwd>phenotypes</kwd><kwd>hyaluronic acid</kwd><kwd>Hylan G-F 20</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008 Feb;16(2):137-62. doi:10.1016/j.joca.2007.12.013.</mixed-citation><mixed-citation xml:lang="en">Zhang W, Moskowitz RW, Nuki G, et al. 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