mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2017-1-4-11mrj-731Research ArticleЛЕКЦИИLECTURESОстеоартрит и возраст. Роль старения в этиологии и патогенезе заболеванияOsteoarthritis and age. Role of aging in the etiology and pathogenesis of the diseaseЛучихинаЛ. В.LuchikhinaL. V.

117997, г. Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

laluch1@mail.ruМендельО. И.MendelO. I.

117997, г. Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

МендельВ.MendelV.

117997, г. Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

ГолуховГ. Н.GolukhovG. N.

117997, г. Москва, ул. Островитянова, 1

1, Ostrovityanov St., Moscow 117997

ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation201724032017111411Copyright © Лучихина Л.В., Мендель О.И., Мендель В., Голухов Г.Н., 20172017Лучихина Л.В., Мендель О.И., Мендель В., Голухов Г.Н.Luchikhina L.V., Mendel O.I., Mendel V., Golukhov G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/731

В статье рассмотрены современные представления о механизмах развития и прогрессирования остеоартрита (ОА), дана дефиниция заболевания. На молекулярном и клеточном уровне описаны процессы, лежащие в основе старения и ОА, с акцентом на роль хронического неспецифического воспаления. Охарактеризованы возможные механизмы развития хронического возраст-ассоциированного воспаления (inflammaging/инфламэйджинг), базовым из которых является общее старение системы иммунитета. На основании данных литературы сделан вывод о том, что старение и ОА имеют общие каскады внутриклеточной транскрипции и патофизиологические механизмы: хроническое неспецифическое воспаление и метаболические нарушения существенно вовлечены в патогенез этих состояний. Отмечено, что метаболические и структурные изменения, происходящие в хряще и других тканях опорно-двигательного аппарата при старении, служат благоприятной платформой для дальнейшего развития и прогрессирования ОА

The paper considers current views on the mechanisms for the development and progression of osteoarthritis (OA) and gives the definition of the disease. It describes the processes underlying aging and OA at the molecular and cellular level, with emphasis on the role of chronic nonspecific inflammation. The possible mechanisms of chronic age-related inflammation (inflammaging), the mainstay of which is systemic aging of the immune system, are characterized. On the basis of the data available in the literature, it is concluded that aging and OA have common intracellular transcription cascades and pathophysiological mechanisms: chronic nonspecific inflammation and metabolic disorders are substantially implicated in the pathogenesis of these conditions. Metabolic and structural changes occurring in the cartilage and other tissues of the locomotor apparatus with aging are noted to serve as a favorable platform for the further development and progression of OA.

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The authors declare that there are no conflicts of interest present.