References

mrj

Современная ревматология

Modern Rheumatology Journal

1996-70122310-158X

IMA-PRESS, LLC

10.14412/1996-7012-2017-1-38-45

mrj-737

Research Article

ОБЗОРЫ

REVIEWS

Что нового? Обзор международных публикаций за 2016г., посвященных проблемам эффективности и безопасности нестероидных противовоспалительных препаратов

What is new? An overview of the 2016 international publications on the efficacy and safety of nonsteroidal anti-inflammatory drugs

Каратеев

А. Е.

Karateev

A. E.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115552

aekarat@yandex.ru

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation

2017

24032017

1113845

2017

Каратеев А.Е.

Karateev A.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://mrj.ima-press.net/mrj/article/view/737

Нестероидные противовоспалительные препараты (НПВП) – основное средство патогенетической терапии острой и хронической боли, связанной с ревматическими заболеваниями. Казалось бы, НПВП прекрасно изучены: известны их фармакологические свойства, определены области применения, эффективность при различных заболеваниях и патологических состояниях, возможные нежелательные реакции и методы их профилактики. И тем не менее эта лекарственная группа до настоящего времени остается одной из наиболее обсуждаемых в мировой медицинской литературе. Не утихают споры о терапевтической ценности НПВП, соотношении их лечебного потенциала и риска осложнений, целесообразности длительного применения при ряде нозологических форм. Постоянно появляются сообщения о новых исследованиях, результаты которых изменяют сложившееся мнение о многих аспектах использования НПВП в реальной клинической практике. Представлен краткий обзор некоторых наиболее интересных и значимых работ, посвященных НПВП, появившихся в мировой медицинский печати за минувший 2016 г.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of pathogenetic therapy for acute and chronic pain associated with rheumatic diseases. It would seem that NSAIDs are well studied: their pharmacological properties are known; the fields of their applications, the efficacy of the drugs in treating various diseases and pathological conditions, possible adverse reactions (ARs), and methods for their prevention have been identified. Nevertheless, this drug group has so far remained one of the most debated topics in the international medical literature. Debates continue about the therapeutic value of NSAIDs, the ratio of their therapeutic potential and the risk of complications, and the expediency of their long use in a number of nosological entities. There are constantly reports of new studies that modify the existing view on many aspects of using NSAIDs in real clinical practice. The paper gives a brief overview of some of the most interesting and significant works on NSAIDs, which appeared in the world medical press in the past 2016.

нестероидные противовоспалительные препаратыэффективностьбезопасностьостеоартриткардиоваскулярные осложненияНПВП-энтеропатия

nonsteroidal anti-inflammatory drugsefficacysafetyosteoarthritiscardiovascular complicationsNSAID enteropathy

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The authors declare that there are no conflicts of interest present.