mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2017-1-66-71mrj-741Research ArticleОБЗОРЫREVIEWSИнформационная ценность прокальцитонина в определении природы воспалительной реакции в ревматологииInformative value of procalcitonin in determining the nature of an inflammatory response in rheumatologyТепляковаО. В.TeplyakovaO. V.

620028, Екатеринбург, ул. Репина, 3

3, Repin St., Yekaterinburg 620028

oteplyakova69@gmail.comРудновВ. А.RudnovV. A.

620028, Екатеринбург, ул. Репина, 3

620102, Екатеринбург, ул. Волгоградская, 189

3, Repin St., Yekaterinburg 620028

189, Volgogradskaya St., Yekaterinburg 620102

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава РоссииРоссияUral State Medical University, Ministry of Health of RussiaRussian FederationФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России Муниципальное автономное учреждение «Городская клиническая больница №40»РоссияUral State Medical University, Ministry of Health of Russia City Clinical Hospital FortyRussian Federation2017240320171116671Copyright © Теплякова О.В., Руднов В.А., 20172017Теплякова О.В., Руднов В.А.Teplyakova O.V., Rudnov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/741

Представлен обзор литературы, касающийся использования прокальцитонина (ПКТ) в качестве маркера, обеспечивающего проведение дифференциальной диагностики между диффузными болезнями соединительной ткани, системными васкулитами в активной стадии и проявлениями системной бактериальной инфекции. Уровень дискриминационной значимости ПКТ в большинстве случаев варьирует от 0,1 до 0,5 нг/мл. В то же время установлено, что при некоторых формах системных васкулитов (болезнь Стилла у взрослых, синдром активации макрофагов) уровень ПКТ может соответствовать таковому при системных бактериальных инфекциях. В связи с этим роль ПКТ не следует абсолютизировать – он служит только важным подспорьем при использовании современных методов лучевой, микробиологической и лабораторной диагностики. Повысить диагностическую ценность ПКТ в данных клинических ситуациях возможно при сочетанном определении его содержания в крови и тяжести органной дисфункции по шкале SOFA (Sepsis-related Organ Failure).

The paper reviews the literature regarding the use of procalcitonin (PCT) as a marker providing a differential diagnosis between diffuse connective tissue diseases, active systemic vasculitis, and manifestations of systemic bacterial infection. The discriminatory significance of PCT in most cases varies from 0.1 to 0.5 ng/ml. At the same time it has been found that the level of PCT in some forms of systemic vasculitis (adultonset Still's disease, macrophage activation syndrome) may correspond to that in systemic bacterial infections. In this connection, the role of PCT should not be absolutized; it may serve only as a great help using the current methods for X-ray, microbiological, and laboratory investigation. The diagnostic value of PCT in these clinical situations can be enhanced by the combined determination of its blood levels and the severity of organ dysfunction in accordance with the Sepsis-related Organ Failure Assessment (SOFA) scale.

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The authors declare that there are no conflicts of interest present.