mrjСовременная ревматологияModern Rheumatology Journal1996-70122310-158XIMA-PRESS, LLC10.14412/1996-7012-2017-1-79-86mrj-743Research ArticleОБЗОРЫREVIEWSАнтитела к циклическому цитруллинированному пептиду – роль при ревматоидном артрите и возможность сероконверсии: фокус на абатацептAnti-cyclic citrullinated peptide antibodies – a role in rheumatoid arthritis and the possibility of seroconversion: A focus on abataceptЧичасоваН. В.ChichasovaN. V.

Кафедра ревматологии

119048, Москва, ул. Трубецкая, 8, стр. 2

Department of Rheumatology

8, Trubetskaya St., Build. 2, Moscow 119048

kafedrarheum@yandex.ruФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»РоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation2017240320171117986Copyright © Чичасова Н.В., 20172017Чичасова Н.В.Chichasova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://mrj.ima-press.net/mrj/article/view/743

Выявление антител к циклическому цитруллинированному пептиду (АЦЦП) играет диагностическую и прогностическую роль при ревматоидном артрите (РА). Снижение концентрации АЦЦП или их сероконверсия отмечены не для всех групп противовоспалительных препаратов. Серопозитивность по АЦЦП является предиктором более высокой эффективности абатацепта (АБЦ). Возможность сероконверсии АЦЦП, как и ревматоидного фактора (РФ), при терапии АБЦ сопряжена с более выраженным подавлением клинических симптомов активности РА и прогрессирования деструкции суставов, достижением ремиссии у большой части пациентов.

The detection of anti-cyclic citrullinated peptide (anti-CCP) antibodies plays a diagnostic and statistical predictive role in rheumatoid arthritis (RA). The decreased concentration of anti-CCP antibodies or their seroconversion is observed for not all groups of anti-inflammatory drugs. Seropositivity for anti-CCP antibodies is a predictor of the higher efficacy of abatacept (ABC). The possibility of seroconversion of anti-CCP antibodies, like rheumatoid factor, during treatment with ABC is associated with the more pronounced suppression of clinical symptoms of RA activity and progressive joint destruction, with remission achievement in a large proportion of patients.

серопозитивностьсероконверсияантитела к циклическому цитруллинированному пептидуревматоидный артритревматоидный факторабатацептseropositivityseroconversionanti-cyclic citrullinated peptide antibodiesrheumatoid arthritisrheumatoid factorabatacept.ReferencesSmolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010 Apr;69(4):631-7. doi: 10.1136/ard.2009.123919. Epub 2010 Mar 9.Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010 Apr;69(4):631-7. doi: 10.1136/ard.2009.123919. Epub 2010 Mar 9.Nasonov EL, Karateev DE. Does Russia need a treat-to-target initiative? Adopting a global strategy to improve outcomes locally. Rheumatology (Oxford). 2015 Mar;54(3): 381-2. doi: 10.1093/rheumatology/keu156. Epub 2014 Apr 15.Nasonov EL, Karateev DE. Does Russia need a treat-to-target initiative? 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The authors declare that there are no conflicts of interest present.